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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:8-OH-DPAT
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Accession:CHEBI:73364 term browser browse the term
Definition:A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Synonyms:exact_synonym: 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
 related_synonym: 8-Hydroxy-2-(di-n-propylamino)tetralin;   Formula=C16H25NO;   InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3;   InChIKey=ASXGJMSKWNBENU-UHFFFAOYSA-N;   SMILES=CCCN(CCC)C1CCc2cccc(O)c2C1
 xref: CAS:78950-78-4;   LINCS:LSM-21609
 xref_mesh: MESH:D017371
 xref: PMID:22727480;   PMID:23249525;   PMID:23303072;   PMID:23336054;   PMID:23395768;   PMID:23551660;   PMID:235975627;   Reaxys:3546291;   Wikipedia:8-OH-DPAT


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8-OH-DPAT term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein] CTD PMID:30366073 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of ARC mRNA] CTD PMID:19695244 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]
CTD PMID:30366073 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein] CTD PMID:30366073 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO 8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein]
CTD PMID:30366073 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO 8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]
CTD PMID:30366073 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin] CTD PMID:14575894 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Levodopa results in increased expression of FOS protein]
8-Hydroxy-2-(di-n-propylamino)tetralin affects the reaction [Haloperidol results in increased expression of FOS protein]
CTD PMID:18585397, PMID:19115412, PMID:19695244 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA] CTD PMID:19695244 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [[Sarin co-treated with 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide] results in increased expression of GFAP protein] CTD PMID:23692952 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A affects binding
increases expression
multiple interactions
increases activity
ISO
EXP
8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein
8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA; 8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein
4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; 8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]; 8-Hydroxy-2-(di-n-propylamino)tetralin binds to and affects the activity of HTR1A protein; 8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to 1-(3-chlorophenyl)piperazine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin; [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine; Cocaine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]; Diazinon promotes the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]; Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form]; Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]; Fluoxetine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]; Parathion inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]; Streptozocin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]
8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide analog inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]; 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]; methamidophos inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]; NCF1 protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; NCF1 protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]; PRKCD protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; PRKCD protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]
CTD PMID:2533336, PMID:8539317, PMID:9723786, PMID:9809859, PMID:10640309, PMID:10665824, PMID:11927170, PMID:12591222, PMID:14767715, PMID:15482641, PMID:15798786, PMID:15893579, PMID:16528294, PMID:17035140, PMID:17300168, PMID:18622176, PMID:19211973, PMID:20580787, PMID:21520940, PMID:21871486, PMID:22265196, PMID:30366073 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO 8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR7 protein CTD PMID:15802305 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein] CTD PMID:30366073 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B multiple interactions ISO 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15802305 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [[Sarin co-treated with 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide] results in increased expression of IL1B protein]
CTD PMID:15802305, PMID:23692952 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]
CTD PMID:15802305, PMID:30366073 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of JUNB mRNA] CTD PMID:19695244 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]; 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]; 8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein]; NCF1 protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; NCF1 protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]; PRKCD protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein] CTD PMID:30366073 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of NR4A1 mRNA] CTD PMID:19695244 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions EXP [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form; Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form] CTD PMID:22265196 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Pdyn prodynorphin multiple interactions EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Levodopa results in increased expression of PDYN mRNA] CTD PMID:19115412 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form; Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form] CTD PMID:22265196 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]; 8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]; 8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of and results in increased phosphorylation of PRKCD protein; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; PRKCD protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; PRKCD protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]; PRKCD protein affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]] CTD PMID:30366073 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein] CTD PMID:30366073 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc6a4 solute carrier family 6 member 4 increases response to substance EXP SLC6A4 results in increased susceptibility to 8-Hydroxy-2-(di-n-propylamino)tetralin CTD PMID:18581099 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:15802305 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        environmental contaminant 18575
          naphthalene 2342
            tetralin 145
              8-OH-DPAT 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  cyclic hydrocarbon 17065
                                    arene 17061
                                      polycyclic arene 16882
                                        ortho-fused polycyclic arene 9643
                                          ortho-fused bicyclic arene 2395
                                            naphthalene 2342
                                              tetralin 145
                                                8-OH-DPAT 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.