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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:U69593
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Accession:CHEBI:73357 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine.
Synonyms:exact_synonym: N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide
 related_synonym: (5alpha,7alpha,8beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-benzeneacetamide;   Formula=C22H32N2O2;   InChI=1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1;   InChIKey=PGZRDDYTKFZSFR-ONTIZHBOSA-N;   N-methyl-N-((5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-benzeneacetamide;   SMILES=CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1ccccc1;   U 69,593;   U-69593
 xref: CAS:96744-75-1
 xref_mesh: MESH:C045444
 xref: PMID:18929596;   PMID:19747933;   PMID:20939060;   PMID:21883413;   PMID:22306346;   PMID:22641418;   PMID:22816017;   PMID:23318874;   PMID:23597562;   PMID:235975627;   PMID:2836684;   PMID:2986999;   Reaxys:7488908;   Wikipedia:U-69\,593


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U69593 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP U 69593 results in increased phosphorylation of MAPK1 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16954126 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP U 69593 results in increased phosphorylation of MAPK3 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16954126 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding ISO U 69593 binds to OPRD1 protein CTD PMID:7562497 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding		 ISO [U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]; U 69593 binds to and results in increased activity of OPRK1 protein
U 69593 binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]; U 69593 binds to and results in increased activity of OPRK1 protein		 CTD PMID:7562497 PMID:11113311 PMID:15456805 PMID:21866885 PMID:21958337 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding ISO U 69593 binds to OPRM1 protein CTD PMID:7562497 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pdyn prodynorphin multiple interactions ISO U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] CTD PMID:11532335 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Penk preproenkephalin multiple interactions ISO U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PENK mRNA] CTD PMID:11532335 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819 		JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA] CTD PMID:11532335 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
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  CHEBI ontology 22178
    role 22194
      application 21744
        anti-inflammatory agent 17331
          U69593 8
Path 2
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  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              monocarboxylic acid amide 15820
                                                U69593 8
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