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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:U69593
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Accession:CHEBI:73357 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine.
Synonyms:exact_synonym: N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide
 related_synonym: (5alpha,7alpha,8beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-benzeneacetamide;   Formula=C22H32N2O2;   InChI=1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1;   InChIKey=PGZRDDYTKFZSFR-ONTIZHBOSA-N;   N-methyl-N-((5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-benzeneacetamide;   SMILES=CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1ccccc1;   U 69,593;   U-69593
 xref: CAS:96744-75-1
 xref_mesh: MESH:C045444
 xref: PMID:18929596;   PMID:19747933;   PMID:20939060;   PMID:21883413;   PMID:22306346;   PMID:22641418;   PMID:22816017;   PMID:23318874;   PMID:23597562;   PMID:235975627;   PMID:2836684;   PMID:2986999;   Reaxys:7488908;   Wikipedia:U-69\,593


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U69593 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO U 69593 results in increased phosphorylation of MAPK1 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK1 protein]
CTD PMID:16954126 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO U 69593 results in increased phosphorylation of MAPK3 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK3 protein]
CTD PMID:16954126 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP U 69593 binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
U 69593 binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]; U 69593 binds to and results in increased activity of OPRK1 protein
[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]; U 69593 binds to and results in increased activity of OPRK1 protein
CTD PMID:7562497 PMID:11113311 PMID:15456805 PMID:21866885 PMID:21958337 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP U 69593 binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdyn prodynorphin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] CTD PMID:11532335 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PENK mRNA] CTD PMID:11532335 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA] CTD PMID:11532335 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link

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  CHEBI ontology 19810
    role 19758
      application 19420
        anti-inflammatory agent 14959
          U69593 8
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  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  U69593 8
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