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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:U69593
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Accession:CHEBI:73357 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine.
Synonyms:exact_synonym: N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide
 related_synonym: (5alpha,7alpha,8beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-benzeneacetamide;   Formula=C22H32N2O2;   InChI=1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1;   InChIKey=PGZRDDYTKFZSFR-ONTIZHBOSA-N;   N-methyl-N-((5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-benzeneacetamide;   SMILES=CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1ccccc1;   U 69,593;   U-69593
 xref: CAS:96744-75-1
 xref_mesh: MESH:C045444
 xref: PMID:18929596;   PMID:19747933;   PMID:20939060;   PMID:21883413;   PMID:22306346;   PMID:22641418;   PMID:22816017;   PMID:23318874;   PMID:23597562;   PMID:235975627;   PMID:2836684;   PMID:2986999;   Reaxys:7488908;   Wikipedia:U-69\,593


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U69593 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		ISO U 69593 results in increased phosphorylation of MAPK1 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK1 protein] 		CTD PMID:16954126 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO U 69593 results in increased phosphorylation of MAPK3 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK3 protein] 		CTD PMID:16954126 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP U 69593 binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions 		EXP
ISO 		U 69593 binds to OPRK1 protein
[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]; U 69593 binds to and results in increased activity of OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]; U 69593 binds to and results in increased activity of OPRK1 protein 		CTD PMID:7562497 PMID:11113311 PMID:15456805 PMID:21866885 PMID:21958337 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP U 69593 binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] CTD PMID:11532335 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PENK mRNA] CTD PMID:11532335 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA] CTD PMID:11532335 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
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  CHEBI ontology 20856
    role 20816
      application 20617
        anti-inflammatory agent 16836
          U69593 8
Path 2
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  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              monocarboxylic acid amide 15949
                                                U69593 8
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