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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:73356 term browser browse the term
Definition:A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.
Synonyms:exact_synonym: (4S,7S,13S)-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-13-(L-tyrosylamino)-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
 related_synonym: (D-Pen2,D-Pen5)-Enkephalin;   2,5-Pen-enkephalin;   D-penicillamine-(2,5)-enkephalin;   Formula=C30H39N5O7S2;   H-Tyr-c(D-Pen-Gly-Phe-D-Pen)-OH;   H-Tyr-cyclo-(D-Pen-Gly-Phe-D-Pen)-OH;   InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1;   InChIKey=MCMMCRYPQBNCPH-WMIMKTLMSA-N;   L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-D-valine, cyclic (2-5)-disulfide;   SMILES=CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O;   [D-Pen(2)-D-Pen(5)]-enkephaline;   c[D-Pen(2,5)]-enkephalin;   cyclo-[D-Pen(2,5)]-enkephalin
 xref: CAS:88373-73-3;   KEGG:C20164
 xref_mesh: MESH:D020881
 xref: PMID:22995282;   PMID:23203254;   PMID:23564013;   PMID:23597562;   Reaxys:3586429

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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)- CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
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                                                peptide 21
                                                  cyclic peptide 4
                                                    heterodetic cyclic peptide 2
                                                      DPDPE 1
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