ultraviolet filter - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ultraviolet filter	go back to main search page
Accession:	CHEBI:73335	browse the term
Definition:	A photochemical role realized in the absorption of ultraviolet light, for example to protect skin cells from damage.
Synonyms:	related_synonym:	UV filter; UV filters; ultraviolet filters
	xref:	wikipedia.en:UV_filter

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Rat (383 ) Mouse (370 ) Human (376 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (1 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (383)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin II receptor, type 1a

multiple interactions

EXP

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR1A mRNA]

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

angiotensin II receptor, type 2

multiple interactions

EXP

esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA]

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

AKT serine/threonine kinase 1

increases phosphorylation

ISO

esculetin results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

arachidonate 15-lipoxygenase

decreases expression

ISO

esculetin results in decreased expression of ALOX15 protein

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

BCL2-antagonist/killer 1

increases expression

ISO

esculetin results in increased expression of BAK1 protein

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects localization
affects expression
increases expression

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of BAX protein
esculetin affects the localization of BAX protein
esculetin affects the expression of BAX protein
esculetin results in increased expression of BAX protein

PMID:16051289 PMID:19786087 PMID:24995577 PMID:26388407 PMID:31313495

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

affects expression
decreases expression

ISO

esculetin affects the expression of BCL2 protein
esculetin results in decreased expression of BCL2 protein

PMID:24995577 PMID:26388407 PMID:31313495

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

ISO

[esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein
esculetin results in decreased expression of BCL2L1 protein

PMID:16051289 PMID:26388407

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

BH3 interacting domain death agonist

multiple interactions

ISO

[arsenic trioxide co-treated with esculetin] results in increased cleavage of BID protein

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

bone morphogenetic protein 6

multiple interactions

EXP

esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA]

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

caspase 3

multiple interactions
increases activity
increases cleavage

ISO

[esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein
esculetin results in increased activity of CASP3 protein
esculetin results in increased cleavage of CASP3 protein

PMID:16051289 PMID:24995577 PMID:26388407 PMID:31313495

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases cleavage

ISO

esculetin results in increased cleavage of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity
increases cleavage

ISO

esculetin results in increased activity of CASP9 protein
esculetin results in increased cleavage of CASP9 protein

PMID:24995577 PMID:26388407 PMID:31313495

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP

esculetin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

decreases expression

EXP
ISO

esculetin results in decreased expression of CCND1 protein

PMID:21600278 PMID:31313495

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin dependent kinase 2

decreases expression
multiple interactions

EXP

esculetin results in decreased expression of CDK2 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

decreases expression
multiple interactions

EXP

esculetin results in decreased expression of CDK4 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein]

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

EXP
ISO

esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein]

PMID:21600278 PMID:31313495

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

esculetin results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

catechol-O-methyltransferase

increases methylation

ISO

COMT protein results in increased methylation of esculetin

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

cytochrome c, somatic

multiple interactions

ISO

[arsenic trioxide co-treated with esculetin] affects the localization of CYCS protein; [esculetin co-treated with Paclitaxel] affects the localization of CYCS protein

PMID:16051289 PMID:19428345

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

Fas cell surface death receptor

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fatty acid synthase

multiple interactions

ISO

esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibronectin 1

multiple interactions

EXP

esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

ISO

esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC1 protein]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

interleukin 6

multiple interactions

ISO

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO
EXP

[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]

PMID:16051289 PMID:21600278 PMID:24995577

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO
EXP

[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
esculetin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]

PMID:16051289 PMID:21600278 PMID:24995577

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions
increases expression
increases phosphorylation

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein
esculetin results in increased expression of MAPK8 protein
esculetin results in increased phosphorylation of MAPK8 protein

PMID:16051289 PMID:19786087

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions
increases expression

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein
esculetin results in increased expression of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

matrix metallopeptidase 13

multiple interactions

EXP

esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA]

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

NFE2 like bZIP transcription factor 2

increases localization
affects localization

ISO

esculetin results in increased localization of NFE2L2 protein
esculetin affects the localization of NFE2L2 protein

PMID:20933534 PMID:30171828

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

affects localization

ISO

esculetin affects the localization of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nitric oxide synthase 2

multiple interactions

ISO

esculetin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

EXP

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NOS3 mRNA]; esculetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

esculetin results in increased expression of and results in increased activity of NQO1 protein
esculetin results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

esculetin results in increased cleavage of PARP1 protein

PMID:26388407 PMID:31313495

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

peroxisome proliferator-activated receptor gamma

multiple interactions

EXP
ISO

esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]
esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]

PMID:21450970 PMID:27769711

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

RELA proto-oncogene, NF-kB subunit

affects localization

ISO

esculetin affects the localization of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

superoxide dismutase 1

affects expression

ISO

esculetin affects the expression of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

Sp1 transcription factor

decreases expression

ISO

esculetin results in decreased expression of SP1 protein

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

transforming growth factor, beta 1

multiple interactions

EXP

esculetin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

toll-like receptor 4

multiple interactions

ISO

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 10b

increases expression

ISO

esculetin results in increased expression of TNFRSF10A protein

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

tumor protein p53

increases degradation
increases expression

ISO

esculetin results in increased degradation of TP53 protein
esculetin results in increased expression of TP53 protein

PMID:14634213 PMID:31313495

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

EXP

UGT2B15 protein results in increased metabolism of esculetin

NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467

G

ubiquitin specific peptidase 16

multiple interactions

EXP

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP16 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP16 mRNA]

NCBI chr11:40,166,651...40,196,792
Ensembl chr11:40,167,692...40,196,823

G

ubiquitin specific peptidase 22

multiple interactions

EXP

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP22 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP22 mRNA]

NCBI chr10:46,328,092...46,354,939
Ensembl chr10:46,328,092...46,371,723

G

vascular cell adhesion molecule 1

multiple interactions

EXP

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of VCAM1 mRNA]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase family, member 10

increases expression

EXP

oxybenzone results in increased expression of ACAD10 mRNA

NCBI chr12:40,561,900...40,604,378
Ensembl chr12:40,566,701...40,604,378

G

acyl-CoA dehydrogenase family, member 9

increases expression

EXP

oxybenzone results in increased expression of ACAD9 mRNA

NCBI chr 2:120,871,329...120,894,306
Ensembl chr 2:120,871,227...120,894,709

G

acyl-CoA binding domain containing 3

decreases expression

EXP

oxybenzone results in decreased expression of ACBD3 mRNA

NCBI chr13:94,987,643...95,016,356
Ensembl chr13:94,987,541...95,016,355

G

acetylcholinesterase

decreases expression

ISO

oxybenzone results in decreased expression of ACHE mRNA

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

aconitase 2

affects expression

EXP

oxybenzone affects the expression of ACO2 mRNA

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 2

increases expression

EXP

oxybenzone results in increased expression of ACOT2 mRNA

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

acyl-CoA oxidase 1

increases expression

EXP

oxybenzone results in increased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acyl-CoA synthetase long-chain family member 5

decreases expression

EXP

oxybenzone results in decreased expression of ACSL5 mRNA

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943

G

acyl-CoA synthetase short-chain family member 2

increases expression

EXP

oxybenzone results in increased expression of ACSS2 mRNA

NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830

G

activin A receptor like type 1

decreases expression

ISO

oxybenzone results in decreased expression of ACVRL1 mRNA

NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases expression

ISO

oxybenzone results in decreased expression of ADAMTS1 mRNA

NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390

G

adenylate cyclase 4

decreases expression

ISO

oxybenzone results in decreased expression of ADCY4 mRNA

NCBI chr15:33,236,201...33,252,070
Ensembl chr15:33,236,208...33,252,026

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO

oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]

PMID:32407875 PMID:34864131

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adenosine A2B receptor

decreases expression

ISO

oxybenzone results in decreased expression of ADORA2B mRNA

NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091

G

ADP-ribosylhydrolase like 1

affects expression

EXP

oxybenzone affects the expression of ADPRHL1 mRNA

NCBI chr16:82,985,355...83,017,240

G

aryl hydrocarbon receptor

decreases expression
increases expression

EXP

oxybenzone results in decreased expression of AHR mRNA
oxybenzone results in increased expression of AHR protein

PMID:15458797 PMID:30099065

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

allograft inflammatory factor 1

increases expression

EXP

oxybenzone results in increased expression of AIF1 mRNA; oxybenzone results in increased expression of AIF1 protein

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

AKT serine/threonine kinase 3

increases expression

ISO

oxybenzone results in increased expression of AKT3 mRNA

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020

G

amylase 2a3

increases expression

EXP

oxybenzone results in increased expression of AMY2A3 mRNA

NCBI chr 2:204,005,840...204,014,412
Ensembl chr 2:204,005,840...204,014,413

G

angiopoietin 1

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT1 mRNA

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

angiopoietin 2

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPT2 mRNA

NCBI chr16:77,790,760...77,841,241
Ensembl chr16:77,790,563...77,841,239

G

angiopoietin 4

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT4 mRNA

NCBI chr 3:160,880,539...160,913,923
Ensembl chr 3:160,880,728...160,913,921

G

angiopoietin-like 4

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

APC regulator of WNT signaling pathway

increases expression
decreases expression

ISO

oxybenzone results in increased expression of APC mRNA
oxybenzone results in decreased expression of APC mRNA

PMID:36581016 PMID:39343157

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022

G

apelin

decreases expression

ISO

oxybenzone results in decreased expression of APLN mRNA

NCBI chr X:132,058,739...132,091,518
Ensembl chr X:132,081,759...132,091,246

G

apolipoprotein C3

increases expression

EXP

oxybenzone results in increased expression of APOC3 mRNA

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679

G

apolipoprotein E

decreases expression

ISO

oxybenzone results in decreased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

apolipoprotein L2

increases expression

EXP

oxybenzone results in increased expression of APOL2 mRNA

NCBI chr 7:111,211,944...111,219,209
Ensembl chr 7:111,211,893...111,217,223

G

apolipoprotein L domain containing 1

decreases expression

ISO

oxybenzone results in decreased expression of APOLD1 mRNA

NCBI chr 4:169,499,728...169,557,075
Ensembl chr 4:169,549,679...169,559,176

G

aquaporin 1

decreases expression

EXP
ISO

oxybenzone results in decreased expression of AQP1 mRNA

PMID:30316929 PMID:39343157

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

androgen receptor

multiple interactions
affects localization

ISO
EXP

oxybenzone binds to and results in decreased activity of AR protein; oxybenzone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; oxybenzone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
oxybenzone affects the localization of AR protein

PMID:12730620 PMID:15537743 PMID:15950433 PMID:30099065 PMID:33049310

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

amphiregulin

increases expression
decreases expression

ISO

oxybenzone results in increased expression of AREG mRNA
oxybenzone results in decreased expression of AREG mRNA

PMID:31939680 PMID:38382712

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

activating transcription factor 2

increases expression

ISO

oxybenzone results in increased expression of ATF2 mRNA

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

autophagy related 2B

increases expression

ISO

oxybenzone results in increased expression of ATG2B mRNA

NCBI chr 6:130,286,979...130,357,109
Ensembl chr 6:130,286,986...130,357,109

G

ATM serine/threonine kinase

increases expression

ISO

oxybenzone results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATP synthase F1 subunit alpha

increases expression

EXP

oxybenzone results in increased expression of ATP5F1A mRNA

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATP synthase F1 subunit beta

increases expression

EXP

oxybenzone results in increased expression of ATP5F1B mRNA

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase F1 subunit gamma

increases expression

EXP

oxybenzone results in increased expression of ATP5F1C mRNA

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

ATP synthase membrane subunit c locus 2

decreases expression

EXP

oxybenzone results in decreased expression of ATP5MC2 mRNA

NCBI chr 7:135,669,847...135,680,839
Ensembl chr 7:135,669,848...135,678,231

G

ATR serine/threonine kinase

increases expression

ISO

oxybenzone results in increased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

BCL2-associated agonist of cell death

increases expression

EXP

oxybenzone results in increased expression of BAD mRNA

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2-antagonist/killer 1

increases expression

EXP

oxybenzone results in increased expression of BAK1 mRNA; oxybenzone results in increased expression of BAK1 protein

PMID:30099065 PMID:30316929

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

oxybenzone results in increased expression of BAX mRNA; oxybenzone results in increased expression of BAX protein

PMID:30099065 PMID:30316929

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl2-like 1

decreases expression

EXP

oxybenzone results in decreased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

increases expression

EXP

oxybenzone results in increased expression of BCS1L mRNA

NCBI chr 9:83,614,045...83,618,052
Ensembl chr 9:83,613,975...83,618,257

G

BLM RecQ like helicase

increases expression

ISO

oxybenzone results in increased expression of BLM mRNA

NCBI chr 1:143,819,072...143,905,300
Ensembl chr 1:143,819,090...143,905,210

G

BRCA1, DNA repair associated

increases expression

ISO

oxybenzone results in increased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

similar to human chromosome 4 open reading frame 36

decreases expression

EXP

oxybenzone results in decreased expression of AFF1-AS1 mRNA

NCBI chr14:6,363,170...6,370,479
Ensembl chr14:6,363,215...6,370,478

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

increases expression

ISO

oxybenzone results in increased expression of CACNA2D1 mRNA

NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147

G

calreticulin

decreases expression

ISO

oxybenzone results in decreased expression of CALR mRNA

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

caspase 1

decreases expression

EXP

oxybenzone results in decreased expression of CASP1 mRNA

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 2

increases expression

EXP

oxybenzone results in increased expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases activity
multiple interactions

EXP

oxybenzone results in increased activity of CASP3 protein
oxybenzone results in increased expression of and results in increased activity of CASP3 protein

PMID:30099065 PMID:31368502

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

decreases expression

EXP

oxybenzone results in decreased expression of CASP4 mRNA

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 9

increases activity
increases expression

EXP

oxybenzone results in increased activity of CASP9 protein
oxybenzone results in increased expression of CASP9 mRNA

PMID:30099065 PMID:30316929

Ensembl chr 5:159,391,188...159,409,648

G

C-C motif chemokine ligand 21

decreases expression

EXP

oxybenzone results in decreased expression of CCL21 mRNA

NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:61,776,413...61,777,540

G

cyclin E2

increases expression

ISO

oxybenzone results in increased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cadherin 5

decreases expression

ISO

oxybenzone results in decreased expression of CDH5 mRNA

NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

ISO

oxybenzone results in increased expression of CHUK mRNA

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

increases expression

EXP

oxybenzone results in increased expression of CITED4 mRNA

NCBI chr 5:139,532,165...139,533,056
Ensembl chr 5:139,531,584...139,533,361

G

claudin 1

decreases expression

ISO

oxybenzone results in decreased expression of CLDN1 mRNA

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

claudin 11

decreases expression

ISO

oxybenzone results in decreased expression of CLDN11 mRNA

NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:114,136,234...114,149,539

G

claudin 5

decreases expression

ISO

oxybenzone results in decreased expression of CLDN5 mRNA
oxybenzone results in decreased expression of CLDN5 protein

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

C-type lectin domain containing 14A

decreases expression

ISO

oxybenzone results in decreased expression of CLEC14A mRNA

NCBI chr 6:81,616,414...81,619,556
Ensembl chr 6:81,612,953...81,619,614

G

cytochrome c oxidase assembly homolog COX15

increases expression

EXP

oxybenzone results in increased expression of COX15 mRNA

NCBI chr 1:252,554,811...252,571,471
Ensembl chr 1:252,554,811...252,571,471

G

cytochrome c oxidase assembly factor COX16

decreases expression

EXP

oxybenzone results in decreased expression of COX16 mRNA

NCBI chr 6:106,745,424...106,912,523
Ensembl chr 6:106,899,494...106,912,484

G

cytochrome c oxidase copper chaperone COX17

increases expression

EXP

oxybenzone results in increased expression of COX17 mRNA

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

cytochrome c oxidase assembly factor COX18

increases expression

EXP

oxybenzone results in increased expression of COX18 mRNA

NCBI chr14:18,147,558...18,161,622
Ensembl chr14:18,149,992...18,161,619

G

cytochrome c oxidase subunit 5A

increases expression

EXP

oxybenzone results in increased expression of COX5A mRNA

NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279

G

cytochrome c oxidase subunit 6B2

decreases expression

EXP

oxybenzone results in decreased expression of COX6B2 mRNA

NCBI chr 1:78,122,871...78,124,096
Ensembl chr 1:78,122,453...78,124,094

G

cytochrome c oxidase subunit 7A2

decreases expression

EXP

oxybenzone results in decreased expression of COX7A2 mRNA

NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:55,514,261...55,514,512
Ensembl chr 8:55,514,261...55,514,512

G

carnitine palmitoyltransferase 1B

increases expression

EXP

oxybenzone results in increased expression of CPT1B mRNA

NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036

G

carnitine palmitoyltransferase 2

increases expression

EXP

oxybenzone results in increased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

carboxypeptidase X (M14 family), member 2

decreases expression

EXP

oxybenzone results in decreased expression of CPXM2 mRNA

NCBI chr 1:196,266,930...196,377,350
Ensembl chr 1:196,266,930...196,377,347

G

cAMP responsive element binding protein 1

increases expression

ISO

oxybenzone results in increased expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cAMP responsive element binding protein 3-like 1

decreases expression

ISO

oxybenzone results in decreased expression of CREB3L1 mRNA

NCBI chr 3:98,408,240...98,449,104
Ensembl chr 3:98,408,058...98,449,104

G

casein beta

increases expression
decreases methylation

ISO

oxybenzone results in increased expression of CSN2 mRNA; oxybenzone results in increased expression of CSN2 protein
oxybenzone results in decreased methylation of CSN2 promoter

NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,601,824...20,609,060

G

cystatin-like 1

decreases expression

EXP

oxybenzone results in decreased expression of CSTL1 mRNA

NCBI chr 3:156,652,967...156,658,049
Ensembl chr 3:156,653,052...156,658,049

G

catenin beta 1

decreases expression

ISO

oxybenzone results in decreased expression of CTNNB1 mRNA

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cytochrome b reductase 1

increases expression

EXP

oxybenzone results in increased expression of CYBRD1 mRNA

NCBI chr 3:76,342,231...76,369,846
Ensembl chr 3:76,342,404...76,370,061

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

EXP

oxybenzone results in increased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 21, subfamily a, polypeptide 1

decreases expression

EXP

oxybenzone results in decreased expression of CYP21A1 mRNA

NCBI chr20:4,028,323...4,031,549
Ensembl chr20:4,028,391...4,031,543

G

cytochrome P450, family 24, subfamily a, polypeptide 1

decreases expression

EXP

oxybenzone results in decreased expression of CYP24A1 mRNA

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

cytochrome P450, family 26, subfamily C, polypeptide 1

increases expression

EXP

oxybenzone results in increased expression of CYP26C1 mRNA

NCBI chr 1:244,870,412...244,881,610
Ensembl chr 1:244,871,612...244,880,297

G

cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

EXP

oxybenzone results in increased expression of CYP27B1 mRNA

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression

EXP

oxybenzone results in decreased expression of CYP2B3 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily d, polypeptide 3

increases expression

EXP

oxybenzone results in increased expression of CYP2D3 mRNA

NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:115,797,789...115,802,158

G

cytochrome P450, family 4, subfamily a, polypeptide 3

decreases expression

EXP

oxybenzone results in decreased expression of CYP4A3 mRNA

NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:134,334,701...134,352,236

G

cytochrome P450, family 4, subfamily f, polypeptide 17

increases expression

EXP

oxybenzone results in increased expression of CYP4F17 mRNA

NCBI chr 7:12,169,366...12,186,731
Ensembl chr 7:12,169,922...12,187,540

G

cytochrome P450, family 4, subfamily f, polypeptide 18

increases expression

EXP

oxybenzone results in increased expression of CYP4F18 mRNA

NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958

G

cytochrome P450, family 4, subfamily f, polypeptide 40

decreases expression

EXP

oxybenzone results in decreased expression of CYP4F40 mRNA

NCBI chr 7:12,342,121...12,357,974
Ensembl chr 7:12,342,590...12,356,733

G

cytochrome P450 family 7 subfamily A member 1

increases expression

EXP

oxybenzone results in increased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

death-associated protein

decreases expression

EXP

oxybenzone results in decreased expression of DAP mRNA

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:83,910,060...83,962,673

G

death-associated protein kinase 3

increases expression

EXP

oxybenzone results in increased expression of DAPK3 mRNA

NCBI chr 7:9,174,903...9,183,272
Ensembl chr 7:9,174,904...9,183,272

G

death-domain associated protein

increases expression
increases methylation

EXP
ISO

oxybenzone results in increased expression of DAXX mRNA
oxybenzone results in increased methylation of DAXX gene

PMID:30316929 PMID:34523531

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720

G

death effector domain-containing

increases expression

EXP

oxybenzone results in increased expression of DEDD mRNA

NCBI chr13:86,286,341...86,301,789
Ensembl chr13:86,288,350...86,302,446

G

DNA fragmentation factor subunit alpha

increases expression

EXP

oxybenzone results in increased expression of DFFA mRNA

NCBI chr 5:164,823,807...164,836,729
Ensembl chr 5:164,823,807...164,836,728

G

dihydroorotate dehydrogenase

increases expression

EXP

oxybenzone results in increased expression of DHODH mRNA

NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496

G

dihydrolipoamide dehydrogenase

increases expression

ISO

oxybenzone results in increased expression of DLD mRNA

NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:53,619,631...53,652,354

G

delta like canonical Notch ligand 4

decreases expression

ISO

oxybenzone results in decreased expression of DLL4 mRNA

NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763

G

dihydrolipoamide S-succinyltransferase

increases expression

EXP

oxybenzone results in increased expression of DLST mRNA

NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357

G

distal-less homeobox 3

affects expression

EXP

oxybenzone affects the expression of DLX3 mRNA

NCBI chr10:80,561,335...80,566,730
Ensembl chr10:80,561,335...80,566,711

G

cyclin D binding myb-like transcription factor 1

increases expression

ISO

oxybenzone results in increased expression of DMTF1 mRNA

NCBI chr 4:25,864,891...25,905,916
Ensembl chr 4:25,865,447...25,905,943

G

DnaJ heat shock protein family (Hsp40) member C15

decreases expression

EXP

oxybenzone results in decreased expression of DNAJC15 mRNA

NCBI chr15:59,594,314...59,658,862
Ensembl chr15:59,594,314...59,658,987

G

dipeptidylpeptidase 4

decreases expression

ISO

oxybenzone results in decreased expression of DPP4 mRNA

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

dual specificity phosphatase 9

decreases expression

ISO

oxybenzone results in decreased expression of DUSP9 mRNA

NCBI chr X:156,503,237...156,507,162
Ensembl chr X:156,503,190...156,507,161

G

enoyl-CoA hydratase, short chain 1

increases expression

EXP

oxybenzone results in increased expression of ECHS1 mRNA

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

endothelin receptor type A

decreases expression

ISO

oxybenzone results in decreased expression of EDNRA mRNA

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

EGF-like-domain, multiple 7

decreases expression

ISO

oxybenzone results in decreased expression of EGFL7 mRNA

NCBI chr 3:29,802,481...29,814,966
Ensembl chr 3:29,802,690...29,814,951

G

early growth response 1

decreases expression

ISO

oxybenzone results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 4E

increases expression

ISO

oxybenzone results in increased expression of EIF4E mRNA

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

ENAH, actin regulator

decreases expression

ISO

oxybenzone results in decreased expression of ENAH mRNA

NCBI chr13:96,149,437...96,269,841
Ensembl chr13:96,149,437...96,269,796

G

Eph receptor A1

decreases expression

ISO

oxybenzone results in decreased expression of EPHA1 mRNA

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474

G

estrogen receptor 1

decreases expression
increases expression
multiple interactions

EXP
ISO

oxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 protein
oxybenzone results in increased expression of ESR1 mRNA
oxybenzone binds to and results in increased activity of ESR1 protein; oxybenzone promotes the reaction [ESR1 protein binds to ESR1 protein]

PMID:15458797 PMID:16079615 PMID:30099065 PMID:32946892 PMID:33049310 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
affects expression
decreases expression

ISO
EXP

oxybenzone binds to and results in increased activity of ESR2 protein
oxybenzone affects the expression of ESR2 protein
oxybenzone results in decreased expression of ESR2 mRNA

PMID:16079615 PMID:30099065 PMID:33049310

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

estrogen related receptor, alpha

decreases expression

EXP

oxybenzone results in decreased expression of ESRRA mRNA

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

F11 receptor

decreases expression

ISO

oxybenzone results in decreased expression of F11R mRNA

NCBI chr13:86,406,229...86,429,819
Ensembl chr13:86,406,218...86,429,816

G

fatty acid binding protein 4

multiple interactions

ISO

oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]

PMID:32407875 PMID:34864131

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

family with sequence similarity 180, member A

decreases expression

EXP

oxybenzone results in decreased expression of FAM180A mRNA

NCBI chr 4:64,959,999...64,975,176
Ensembl chr 4:64,959,999...64,975,176

G

fibroblast growth factor 2

increases expression

ISO

oxybenzone results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibroblast growth factor receptor-like 1

decreases expression

ISO

oxybenzone results in decreased expression of FGFRL1 mRNA

NCBI chr14:1,154,275...1,166,334
Ensembl chr14:1,154,275...1,166,752

G

filaggrin

affects response to substance
multiple interactions

ISO

FLG gene mutant form affects the susceptibility to oxybenzone
[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Testosterone

NCBI chr 2:181,583,801...181,596,464
Ensembl chr 2:181,583,808...181,595,968

G

Fli-1 proto-oncogene, ETS transcription factor

decreases expression

ISO

oxybenzone results in decreased expression of FLI1 mRNA

NCBI chr 8:39,089,526...39,209,511
Ensembl chr 8:39,089,533...39,208,557

G

fibronectin 1

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

forkhead box C1

decreases expression

ISO

oxybenzone results in decreased expression of FOXC1 mRNA

NCBI chr17:32,840,119...32,844,100
Ensembl chr17:32,805,858...32,844,347

G

forkhead box L2

increases expression
multiple interactions

EXP

oxybenzone results in increased expression of FOXL2 mRNA
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of FOXL2 mRNA]

NCBI chr 8:108,392,466...108,395,553
Ensembl chr 8:108,382,872...108,396,835

G

frizzled-related protein

decreases expression

EXP

oxybenzone results in decreased expression of FRZB mRNA

NCBI chr 3:85,739,162...85,772,168
Ensembl chr 3:85,739,165...85,772,096

G

follicle stimulating hormone subunit beta

multiple interactions

ISO

[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

follistatin

increases expression

EXP

oxybenzone results in increased expression of FST mRNA

NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:47,856,345...47,863,491

G

gamma-aminobutyric acid type A receptor subunit alpha 1

increases expression

ISO

oxybenzone results in increased expression of GABRA1 mRNA

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

glutamate decarboxylase 2

increases expression

ISO

oxybenzone results in increased expression of GAD2 mRNA

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

golgi associated RAB2 interactor 1A

decreases expression

EXP

oxybenzone results in decreased expression of GARIN1A mRNA

NCBI chr 4:58,845,394...58,856,199
Ensembl chr 4:58,845,354...58,856,195

G

golgi associated RAB2 interactor family member 3

decreases expression

EXP

oxybenzone results in decreased expression of GARIN3 mRNA

NCBI chr10:31,331,196...31,334,434
Ensembl chr10:31,331,177...31,334,430

G

glial fibrillary acidic protein

increases expression

ISO

oxybenzone results in increased expression of GFAP mRNA

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

gap junction protein, alpha 4

decreases expression

ISO

oxybenzone results in decreased expression of GJA4 mRNA

NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:144,914,147...144,921,216

G

G protein-coupled estrogen receptor 1

affects expression

EXP

oxybenzone affects the expression of GPER1 protein

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144

G

growth regulating estrogen receptor binding 1

multiple interactions
increases expression

ISO

Fulvestrant inhibits the reaction [oxybenzone results in increased expression of GREB1 mRNA]

NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126

G

gremlin 1, DAN family BMP antagonist

decreases expression

ISO

oxybenzone results in decreased expression of GREM1 mRNA

NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089

G

glutamate ionotropic receptor NMDA type subunit 1

affects expression

EXP

oxybenzone affects the expression of GRIN1 protein

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

affects expression

EXP

oxybenzone affects the expression of GRIN2A protein

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

granulin precursor

decreases expression

ISO

oxybenzone results in decreased expression of GRN mRNA

NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,886,122...87,893,936

G

glycogen synthase kinase 3 beta

decreases expression

ISO

oxybenzone results in decreased expression of GSK3B mRNA

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione S-transferase alpha 2

decreases expression

EXP

oxybenzone results in decreased expression of GSTA2 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 5

decreases expression

EXP

oxybenzone results in decreased expression of GSTA5 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase mu 1

increases expression

EXP

oxybenzone results in increased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase pi 1

increases expression

EXP

oxybenzone results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glutathione S-transferase theta 2

increases expression

EXP

oxybenzone results in increased expression of GSTT2 mRNA

NCBI chr20:12,819,053...12,822,724
Ensembl chr20:12,818,540...12,822,718

G

glutathione S-transferase, theta 3

increases expression

EXP

oxybenzone results in increased expression of GSTT3 mRNA

NCBI chr20:12,873,618...12,881,974
Ensembl chr20:12,874,374...12,881,973

G

glutathione S-transferase, theta 4

decreases expression

EXP

oxybenzone results in decreased expression of GSTT4 mRNA

NCBI chr20:12,834,613...12,841,730
Ensembl chr20:12,834,612...12,841,744

G

granzyme B

decreases expression

ISO

oxybenzone results in decreased expression of GZMB mRNA

NCBI chr15:34,459,007...34,462,469
Ensembl chr15:34,459,007...34,462,469

G

H2A.X variant histone

increases expression
multiple interactions

ISO

oxybenzone results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

EXP

oxybenzone results in decreased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698

G

histone deacetylase 1

increases expression

EXP

oxybenzone results in increased expression of HDAC1 protein

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

histone deacetylase 2

increases expression

EXP

oxybenzone results in increased expression of HDAC2 protein

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311

G

histone deacetylase 9

increases expression

ISO

oxybenzone results in increased expression of HDAC9 mRNA

NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:56,490,988...57,351,835

G

hes family bHLH transcription factor 1

decreases expression

ISO

oxybenzone results in decreased expression of HES1 mRNA

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hes-related family bHLH transcription factor with YRPW motif 1

decreases expression

ISO

oxybenzone results in decreased expression of HEY1 mRNA

NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

ISO

oxybenzone results in increased expression of HIF1A mRNA
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of HIF1A mRNA

PMID:36581016 PMID:38387520

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

helicase-like transcription factor

increases expression

ISO

oxybenzone results in increased expression of HLTF mRNA

NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:104,478,772...104,538,818

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

ISO

oxybenzone results in increased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

ISO

oxybenzone results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

EXP

oxybenzone results in decreased expression of HMGCS2 mRNA

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression

EXP

oxybenzone results in decreased expression of HSD17B10 mRNA

NCBI chr X:24,568,551...24,571,012
Ensembl chr X:24,568,551...24,574,681

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

decreases activity

EXP

oxybenzone results in decreased activity of HSD3B2 protein

NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5

decreases expression

EXP

oxybenzone results in decreased expression of HSD3B5 mRNA

NCBI chr 2:188,697,669...188,717,141
Ensembl chr 2:188,697,670...188,709,118

G

hydroxysteroid dehydrogenase like 2

decreases expression

EXP

oxybenzone results in decreased expression of HSDL2 mRNA

NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:79,212,525...79,274,798

G

heat shock protein 90 alpha family class A member 1

increases expression

ISO

oxybenzone results in increased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

hydroxylysine kinase

increases expression

EXP

oxybenzone results in increased expression of HYKK mRNA

NCBI chr 8:64,212,043...64,235,809
Ensembl chr 8:64,212,071...64,235,818

G

intercellular adhesion molecule 1

multiple interactions
decreases expression

ISO

bisphenol A inhibits the reaction [oxybenzone results in decreased expression of ICAM1 mRNA]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 3

decreases expression

ISO

oxybenzone results in decreased expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

isocitrate dehydrogenase (NADP(+)) 2

decreases expression

EXP

oxybenzone results in decreased expression of IDH2 mRNA

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

increases expression

EXP

oxybenzone results in increased expression of IDH3G mRNA

NCBI chr X:156,666,573...156,675,482
Ensembl chr X:156,666,577...156,675,799

G

interleukin 19

increases expression

EXP

oxybenzone results in increased expression of IL19 mRNA

NCBI chr13:44,949,989...44,958,714
Ensembl chr13:44,949,989...44,958,714

G

insulin 1

multiple interactions

ISO

oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

multiple interactions

ISO

oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

IQ motif containing F6

decreases expression

EXP

oxybenzone results in decreased expression of IQCF6 mRNA

NCBI chr 8:116,142,371...116,143,424
Ensembl chr 8:116,142,350...116,143,441

G

integrin subunit alpha 4

increases expression

ISO

oxybenzone results in increased expression of ITGA4 mRNA

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

integrin subunit alpha 5

decreases expression

ISO

oxybenzone results in decreased expression of ITGA5 mRNA

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305

G

kinase insert domain receptor

decreases expression

ISO

oxybenzone results in decreased expression of KDR mRNA

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

KLF transcription factor 2

decreases expression

ISO

oxybenzone results in decreased expression of KLF2 mRNA

NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768

G

KLF transcription factor 4

decreases expression

ISO

oxybenzone results in decreased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

KRAS proto-oncogene, GTPase

increases expression

ISO

oxybenzone results in increased expression of KRAS mRNA

NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320

G

keratin 18

decreases expression

EXP

oxybenzone results in decreased expression of KRT18 mRNA

NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848

G

LCK proto-oncogene, Src family tyrosine kinase

decreases expression

ISO

oxybenzone results in decreased expression of LCK mRNA

NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267

G

lipocalin 2

decreases expression

ISO

oxybenzone results in decreased expression of LCN2 mRNA

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

lactate dehydrogenase D

increases methylation

ISO

oxybenzone results in increased methylation of LDHD gene

NCBI chr19:56,492,827...56,497,695
Ensembl chr19:56,482,924...56,509,197

G

lymphoid enhancer binding factor 1

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

LIF receptor subunit alpha

increases expression

ISO

oxybenzone results in increased expression of LIFR mRNA

NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364

G

lysyl oxidase-like 1

decreases expression

ISO

oxybenzone results in decreased expression of LOXL1 mRNA

NCBI chr 8:67,587,636...67,612,224
Ensembl chr 8:67,587,636...67,612,224

G

leucine-rich single-pass membrane protein 1

increases expression

EXP

oxybenzone results in increased expression of LSMEM1 mRNA

NCBI chr 6:62,978,880...62,988,750
Ensembl chr 6:62,978,885...62,988,750

G

MAGE family member L2

increases expression

EXP

oxybenzone results in increased expression of MAGEL2 mRNA

NCBI chr 1:125,292,033...125,296,575
Ensembl chr 1:125,292,033...125,296,575

G

monoamine oxidase B

decreases expression

ISO

oxybenzone results in decreased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase kinase 1

decreases expression

ISO

oxybenzone results in decreased expression of MAP2K1 mRNA

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 3

decreases expression

ISO

oxybenzone results in decreased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen-activated protein kinase 6

increases expression

ISO

oxybenzone results in increased expression of MAPK6 mRNA

NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236

G

MCC regulator of WNT signaling pathway

decreases expression

EXP

oxybenzone results in decreased expression of MCC mRNA

NCBI chr18:37,042,350...37,517,114
Ensembl chr18:37,049,253...37,517,076

G

mediator complex subunit 13

increases expression

ISO

oxybenzone results in increased expression of MED13 mRNA

NCBI chr10:71,584,354...71,674,614
Ensembl chr10:71,584,354...71,673,901

G

mesenteric estrogen-dependent adipogenesis

decreases expression

EXP

oxybenzone results in decreased expression of MEDAG mRNA

NCBI chr12:10,649,526...10,670,913
Ensembl chr12:10,649,526...10,692,756

G

matrix Gla protein

decreases expression

ISO

oxybenzone results in decreased expression of MGP mRNA

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859

G

Mov10 RNA helicase

decreases expression

ISO

oxybenzone results in decreased expression of MOV10 mRNA

NCBI chr 2:194,982,014...195,003,513
Ensembl chr 2:194,982,014...195,003,442

G

metallophosphoesterase domain containing 2

increases expression

ISO

oxybenzone results in increased expression of MPPED2 mRNA

NCBI chr 3:113,635,614...113,810,307
Ensembl chr 3:113,635,407...113,811,783

G

MRE11 homolog, double strand break repair nuclease

increases expression

ISO

oxybenzone results in increased expression of MRE11 mRNA

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:19,913,772...19,961,904

G

mutS homolog 2

increases expression

ISO

oxybenzone results in increased expression of MSH2 mRNA

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503

G

MYB proto-oncogene like 1

increases expression
multiple interactions

ISO

oxybenzone results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of MYBL1 mRNA]

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

MYCN proto-oncogene, bHLH transcription factor

increases expression

ISO

oxybenzone results in increased expression of MYCN mRNA

NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:41,446,684...41,452,508

G

NBL1, DAN family BMP antagonist

decreases expression
increases expression

ISO

oxybenzone results in decreased expression of NBL1 mRNA
oxybenzone results in increased expression of NBL1 mRNA

NCBI chr 5:156,601,986...156,613,182
Ensembl chr 5:156,601,986...156,613,186

G

nibrin

increases expression

ISO

oxybenzone results in increased expression of NBN mRNA

NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:34,256,627...34,291,162

G

nuclear receptor coactivator 2

multiple interactions
increases expression

ISO

oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone results in increased expression of NCOA2 mRNA

PMID:32407875 PMID:36581016

NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776

G

NADH:ubiquinone oxidoreductase subunit A11

decreases expression

EXP

oxybenzone results in decreased expression of NDUFA11 mRNA

NCBI chr 9:1,637,614...1,641,673
Ensembl chr 9:1,637,595...1,642,727

G

NADH:ubiquinone oxidoreductase subunit A3

decreases expression

EXP

oxybenzone results in decreased expression of NDUFA3 mRNA

NCBI chr 1:74,512,928...74,515,558
Ensembl chr 1:74,512,928...74,515,558

G

NADH:ubiquinone oxidoreductase subunit A9

increases expression

EXP

oxybenzone results in increased expression of NDUFA9 mRNA

NCBI chr 4:161,345,398...161,374,188
Ensembl chr 4:161,345,400...161,375,025

G

NADH:ubiquinone oxidoreductase subunit AB1

increases expression

EXP

oxybenzone results in increased expression of NDUFAB1 mRNA

NCBI chr 1:186,075,933...186,091,843
Ensembl chr 1:186,057,113...186,089,373

G

NADH:ubiquinone oxidoreductase subunit B10

increases expression

EXP

oxybenzone results in increased expression of NDUFB10 mRNA

NCBI chr10:14,253,805...14,255,966
Ensembl chr10:14,253,805...14,255,966

G

NADH:ubiquinone oxidoreductase subunit B7

increases expression

EXP

oxybenzone results in increased expression of NDUFB7 mRNA

NCBI chr19:41,472,953...41,477,291
Ensembl chr19:41,472,953...41,477,291

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

EXP

oxybenzone results in decreased expression of NDUFS2 mRNA

NCBI chr13:86,186,867...86,203,914
Ensembl chr13:86,186,870...86,203,608

G

NADH:ubiquinone oxidoreductase subunit V3

affects expression

EXP

oxybenzone affects the expression of NDUFV3 mRNA

NCBI chr20:9,613,786...9,622,941
Ensembl chr13:48,468,224...48,488,847
Ensembl chr20:48,468,224...48,488,847

G

nestin

decreases expression

ISO

oxybenzone results in decreased expression of NES protein

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228

G

neurofibromin 1

increases expression

ISO

oxybenzone results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

nuclear factor of activated T-cells 5

increases expression

ISO

oxybenzone results in increased expression of NFAT5 mRNA

NCBI chr19:52,108,982...52,196,418
Ensembl chr19:52,109,483...52,196,418

G

nuclear factor I/A

increases expression

ISO

oxybenzone results in increased expression of NFIA mRNA

NCBI chr 5:117,359,006...117,897,391
Ensembl chr 5:117,359,077...117,891,395

G

nuclear factor I/B

increases expression

ISO

oxybenzone results in increased expression of NFIB mRNA

NCBI chr 5:101,805,168...102,020,618
Ensembl chr 5:101,805,168...102,019,945

G

NK2 homeobox 2

increases expression

ISO

oxybenzone results in increased expression of NKX2-2 mRNA

NCBI chr 3:155,072,621...155,083,699
Ensembl chr 3:155,073,250...155,083,249

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

oxybenzone binds to and results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

increases activity

ISO

oxybenzone results in increased activity of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 2, group F, member 6

decreases expression
increases expression

ISO

oxybenzone results in decreased expression of NR2F6 mRNA
oxybenzone results in increased expression of NR2F6 mRNA

NCBI chr16:18,080,003...18,087,449
Ensembl chr16:18,080,003...18,087,449

G

nuclear receptor subfamily 3, group C, member 1

increases expression

ISO

oxybenzone results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

ISO

oxybenzone results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

Notch-regulated ankyrin repeat protein

decreases expression

ISO

oxybenzone results in decreased expression of NRARP mRNA

NCBI chr 3:28,390,745...28,393,299
Ensembl chr 3:28,390,733...28,393,453

G

nuclear respiratory factor 1

increases expression

EXP

oxybenzone results in increased expression of NRF1 mRNA

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

neuregulin 1

increases expression

ISO

oxybenzone results in increased expression of NRG1 mRNA

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

nuclear receptor interacting protein 1

increases expression

ISO

oxybenzone results in increased expression of NRIP1 mRNA

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353

G

neuropilin 1

decreases expression

ISO

oxybenzone results in decreased expression of NRP1 mRNA

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

netrin 5

increases expression

EXP

oxybenzone results in increased expression of NTN5 mRNA

NCBI chr 1:105,293,408...105,302,163
Ensembl chr 1:105,293,434...105,302,163

G

occludin

decreases expression

ISO

oxybenzone results in decreased expression of OCLN mRNA

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

oxoglutarate dehydrogenase

increases expression
decreases expression

EXP

oxybenzone results in increased expression of OGDH mRNA
oxybenzone results in decreased expression of OGDH mRNA

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

olfactory receptor family 52 subfamily D member 13

increases expression

EXP

oxybenzone results in increased expression of OR52D13 mRNA

NCBI chr 1:167,190,378...167,194,273
Ensembl chr 1:167,190,405...167,194,273

G

programmed cell death 11

increases expression

EXP

oxybenzone results in increased expression of PDCD11 mRNA

NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:255,922,225...255,963,336

G

programmed cell death 6 interacting protein

decreases expression

EXP

oxybenzone results in decreased expression of PDCD6IP mRNA

NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:122,469,223...122,524,993

G

programmed cell death 7

increases expression

EXP

oxybenzone results in increased expression of PDCD7 mRNA

NCBI chr 8:74,757,768...74,772,495
Ensembl chr 8:74,757,768...74,781,634

G

platelet derived growth factor subunit B

decreases expression

ISO

oxybenzone results in decreased expression of PDGFB mRNA

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

platelet derived growth factor receptor alpha

decreases expression

ISO

oxybenzone results in decreased expression of PDGFRA mRNA

NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516

G

platelet and endothelial cell adhesion molecule 1

decreases expression

ISO

oxybenzone results in decreased expression of PECAM1 protein

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

progesterone receptor

multiple interactions
decreases expression
increases expression

ISO

oxybenzone binds to and results in decreased activity of PGR protein
oxybenzone results in decreased expression of PGR mRNA
oxybenzone results in increased expression of PGR mRNA

PMID:15537743 PMID:31939680 PMID:32946892 PMID:38382712 PMID:38431166

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

PHD finger protein 24

increases expression

EXP

oxybenzone results in increased expression of PHF24 mRNA

NCBI chr 5:61,939,261...61,966,879
Ensembl chr 5:61,939,900...61,966,875

G

paired-like homeobox 2b

decreases expression

ISO

oxybenzone results in decreased expression of PHOX2B mRNA

NCBI chr14:41,420,011...41,424,527
Ensembl chr14:41,420,011...41,424,494

G

protein inhibitor of activated STAT, 1

increases expression

ISO

oxybenzone results in increased expression of PIAS1 mRNA

NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:72,233,566...72,334,315

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

ISO

oxybenzone results in increased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

phosphoinositide-3-kinase, regulatory subunit 5

decreases expression

ISO

oxybenzone results in decreased expression of PIK3R5 mRNA

NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539

G

phospholipase D2

decreases expression

ISO

oxybenzone results in decreased expression of PLD2 mRNA

NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435

G

plexin B3

decreases expression

ISO

oxybenzone results in decreased expression of PLXNB3 mRNA

NCBI chr X:156,645,505...156,660,011
Ensembl chr X:156,645,182...156,660,003

G

DNA polymerase mu

decreases expression

EXP

oxybenzone results in decreased expression of POLM mRNA

NCBI chr14:84,921,039...84,930,649
Ensembl chr14:84,921,045...84,930,622

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

oxybenzone results in increased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

affects binding
multiple interactions
increases expression

ISO

oxybenzone binds to PPARG protein
oxybenzone binds to and results in increased activity of PPARG protein
oxybenzone binds to and results in increased activity of PPARG protein; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone results in increased expression of PPARG mRNA

PMID:32407875 PMID:33049310 PMID:34864131

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase 1 catalytic subunit beta

increases expression

ISO

oxybenzone results in increased expression of PPP1CB mRNA

NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:29,681,100...29,712,924

G

prickle planar cell polarity protein 1

decreases expression

ISO

oxybenzone results in decreased expression of PRICKLE1 mRNA

NCBI chr 7:126,518,587...126,614,581
Ensembl chr 7:126,518,587...126,614,581

G

protein kinase cAMP-activated catalytic subunit beta

increases expression

ISO

oxybenzone results in increased expression of PRKACB mRNA

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

protein kinase C, iota

increases expression

ISO

oxybenzone results in increased expression of PRKCI mRNA

NCBI chr 2:114,250,398...114,310,784
Ensembl chr 2:114,250,398...114,310,784

G

serine protease 37

decreases expression

EXP

oxybenzone results in decreased expression of PRSS37 mRNA

NCBI chr 4:70,289,678...70,301,259
Ensembl chr 4:70,289,678...70,302,122

G

phosphatase and tensin homolog

increases expression

ISO

oxybenzone results in increased expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

oxybenzone results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, non-receptor type 4

increases expression

ISO

oxybenzone results in increased expression of PTPN4 mRNA

NCBI chr13:33,324,808...33,504,957
Ensembl chr13:33,324,808...33,504,957

G

RAD17 checkpoint clamp loader component

increases expression

ISO

oxybenzone results in increased expression of RAD17 mRNA

NCBI chr 2:33,498,335...33,528,614
Ensembl chr 2:33,498,336...33,528,144

G

RAD50 double strand break repair protein

increases expression

ISO

oxybenzone results in increased expression of RAD50 mRNA

NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100

G

RAP2A, member of RAS oncogene family

increases expression

ISO

oxybenzone results in increased expression of RAP2A mRNA

NCBI chr15:104,003,744...104,004,234

G

retinoic acid receptor, alpha

decreases expression

ISO

oxybenzone results in decreased expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

RB transcriptional corepressor 1

increases expression

ISO

oxybenzone results in increased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RB1-inducible coiled-coil 1

increases expression

ISO

oxybenzone results in increased expression of RB1CC1 mRNA

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:17,948,522...18,012,434

G

RB binding protein 8, endonuclease

increases expression

ISO

oxybenzone results in increased expression of RBBP8 mRNA

NCBI chr18:3,198,188...3,263,643
Ensembl chr18:3,197,310...3,263,985

G

RB transcriptional corepressor like 1

increases expression

ISO

oxybenzone results in increased expression of RBL1 mRNA

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376

G

REL proto-oncogene, NF-kB subunit

increases expression

ISO

oxybenzone results in increased expression of REL mRNA

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

increases expression

EXP

oxybenzone results in increased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

resistin

decreases expression

EXP

oxybenzone results in decreased expression of RETN mRNA

NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116

G

replication factor C subunit 1

increases expression

ISO

oxybenzone results in increased expression of RFC1 mRNA

NCBI chr14:43,319,768...43,395,028
Ensembl chr14:43,319,935...43,395,026

G

RPTOR independent companion of MTOR, complex 2

increases expression

ISO

oxybenzone results in increased expression of RICTOR mRNA

NCBI chr 2:57,539,279...57,631,291
Ensembl chr 2:57,539,311...57,631,288

G

regulating synaptic membrane exocytosis 2

increases expression

ISO

oxybenzone results in increased expression of RIMS2 mRNA

NCBI chr 7:72,133,004...72,644,059
Ensembl chr 7:72,133,170...72,645,499

G

roundabout guidance receptor 4

decreases expression

ISO

oxybenzone results in decreased expression of ROBO4 mRNA

NCBI chr 8:45,308,739...45,322,522
Ensembl chr 8:45,308,739...45,322,531

G

Rho-associated coiled-coil containing protein kinase 1

increases expression

ISO

oxybenzone results in increased expression of ROCK1 mRNA

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

ISO

oxybenzone results in increased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

ribosomal protein S6 kinase B1

increases expression

ISO

oxybenzone results in increased expression of RPS6KB1 mRNA

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

ISO

oxybenzone results in increased expression of RRM2B mRNA

NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670

G

succinate dehydrogenase complex flavoprotein subunit A

increases expression

EXP

oxybenzone results in increased expression of SDHA mRNA

NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:30,764,590...30,790,121

G

serpin family C member 1

increases expression

EXP

oxybenzone results in increased expression of SERPINC1 mRNA

NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643

G

serpin family E member 2

increases expression

ISO

oxybenzone results in increased expression of SERPINE2 mRNA

NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202

G

serum/glucocorticoid regulated kinase 1

multiple interactions
increases expression

ISO

Fulvestrant inhibits the reaction [oxybenzone results in increased expression of SGK1 mRNA]

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

SH3-domain binding protein 1

decreases expression

ISO

oxybenzone results in decreased expression of SH3BP1 mRNA

NCBI chr 7:112,338,087...112,350,659
Ensembl chr 7:112,338,107...112,350,659

G

SH3 domain -containing GRB2-like endophilin B1

increases expression

EXP

oxybenzone results in increased expression of SH3GLB1 mRNA

NCBI chr 2:236,411,194...236,445,225
Ensembl chr 2:236,410,436...236,445,140

G

SH3 and multiple ankyrin repeat domains 1

increases expression

EXP

oxybenzone results in increased expression of SHANK1 mRNA

NCBI chr 1:103,944,416...103,993,887
Ensembl chr 1:103,944,813...103,992,356

G

solute carrier family 18 member A2

increases expression

ISO

oxybenzone results in increased expression of SLC18A2 mRNA

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 2

affects expression

EXP

oxybenzone affects the expression of SLC1A2 protein

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 6 member 1

increases expression

ISO

oxybenzone results in increased expression of SLC6A1 mRNA

NCBI chr 4:149,004,447...149,037,840
Ensembl chr 4:149,004,635...149,037,839

G

solute carrier family 7 member 11

affects expression

EXP

oxybenzone affects the expression of SLC7A11 protein

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

SMAD family member 9

decreases expression

ISO

oxybenzone results in decreased expression of SMAD9 mRNA

NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477

G

structural maintenance of chromosomes 3

increases expression

ISO

oxybenzone results in increased expression of SMC3 mRNA

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:262,607,080...262,649,825

G

SRY-box transcription factor 18

decreases expression

ISO

oxybenzone results in decreased expression of SOX18 mRNA

NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:189,163,002...189,164,802

G

SRY-box transcription factor 9

multiple interactions
increases expression

EXP

4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of SOX9 mRNA]

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

somatostatin receptor 3

increases expression

EXP

oxybenzone results in increased expression of SSTR3 mRNA

NCBI chr 7:111,973,049...111,980,250
Ensembl chr 7:111,972,811...111,997,368

G

STAG1 cohesin complex component

increases expression

ISO

oxybenzone results in increased expression of STAG1 mRNA

NCBI chr 8:110,057,981...110,443,666
Ensembl chr 8:110,058,056...110,443,665

G

signal transducer and activator of transcription 5A

increases expression
affects localization

ISO

oxybenzone results in increased expression of STAT5A mRNA
oxybenzone affects the localization of STAT5A protein

NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184

G

sulfotransferase family 1A member 1

decreases expression

EXP

oxybenzone results in decreased expression of SULT1A1 mRNA

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2

decreases expression

EXP

oxybenzone results in decreased expression of SULT2A2 mRNA

NCBI chr 1:85,037,518...85,104,532
Ensembl chr 1:84,962,100...85,104,511

G

TATA-box binding protein associated factor 9b

increases expression

ISO

oxybenzone results in increased expression of TAF9B mRNA

NCBI chr X:75,354,823...75,366,166
Ensembl chr X:75,354,825...75,366,414

G

TANK-binding kinase 1

increases expression

ISO

oxybenzone results in increased expression of TBK1 mRNA

NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357

G

transcription factor 7 like 2

increases expression

ISO

oxybenzone results in increased expression of TCF7L2 mRNA

NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225

G

TEK receptor tyrosine kinase

decreases expression

ISO

oxybenzone results in decreased expression of TEK mRNA

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991

G

testis expressed 46

decreases expression

EXP

oxybenzone results in decreased expression of TEX46 mRNA

NCBI chr 5:154,132,763...154,137,196
Ensembl chr 5:154,132,763...154,137,196

G

transcription factor A, mitochondrial

increases expression

EXP
ISO

oxybenzone results in increased expression of TFAM mRNA

PMID:30316929 PMID:36581016

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

trefoil factor 1

multiple interactions
increases expression

ISO

[oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA
oxybenzone results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

transforming growth factor, beta 1

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TGFB1 mRNA; [oxybenzone co-treated with Dietary Fats] results in decreased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta receptor 1

increases expression

ISO

oxybenzone results in increased expression of TGFBR1 mRNA

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

ISO

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 mRNA; [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 protein
oxybenzone results in decreased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

tight junction protein 1

decreases expression

ISO

oxybenzone results in decreased expression of TJP1 mRNA; oxybenzone results in decreased expression of TJP1 protein

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

T-cell leukemia, homeobox 3

decreases expression

ISO

oxybenzone results in decreased expression of TLX3 mRNA

NCBI chr10:18,293,932...18,296,551
Ensembl chr10:18,293,932...18,296,773

G

transmembrane protein 100

decreases expression

ISO

oxybenzone results in decreased expression of TMEM100 mRNA

NCBI chr10:75,351,891...75,357,748
Ensembl chr10:75,351,271...75,360,364

G

transmembrane serine protease 4

increases expression

EXP

oxybenzone results in increased expression of TMPRSS4 mRNA

NCBI chr 8:54,372,805...54,405,157
Ensembl chr 8:54,372,805...54,405,157

G

TNF superfamily member 11

decreases expression

ISO

oxybenzone results in decreased expression of TNFSF11 mRNA

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

DNA topoisomerase II binding protein 1

increases expression

ISO

oxybenzone results in increased expression of TOPBP1 mRNA

NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:112,766,508...112,810,540

G

tumor protein p53

decreases expression

EXP

oxybenzone results in decreased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 binding protein 1

increases expression

ISO

oxybenzone results in increased expression of TP53BP1 protein

NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747

G

translocated promoter region, nuclear basket protein

increases expression

ISO

oxybenzone results in increased expression of TPR mRNA

NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602

G

transient receptor potential cation channel, subfamily V, member 4

decreases expression

ISO

oxybenzone results in decreased expression of TRPV4 mRNA

NCBI chr12:47,599,161...47,638,143
Ensembl chr12:47,599,035...47,638,143

G

translocator protein

decreases expression

EXP

oxybenzone results in decreased expression of TSPO mRNA

NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460

G

twist family bHLH transcription factor 1

multiple interactions

ISO

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TWIST1 mRNA; [oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TWIST1 mRNA

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965

G

UDP glucuronosyltransferase family 1 member A6a

decreases expression

EXP

oxybenzone results in decreased expression of UGT1A6 mRNA

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member A3

decreases expression

EXP

oxybenzone results in decreased expression of UGT2A3 mRNA

NCBI chr14:20,851,970...20,869,974
Ensembl chr14:20,851,969...20,869,973

G

uroplakin 1B

decreases expression

EXP

oxybenzone results in decreased expression of UPK1B mRNA

NCBI chr11:75,459,244...75,496,579
Ensembl chr11:75,459,200...75,496,579

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

EXP

oxybenzone affects the expression of UQCR11 mRNA

NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047

G

ubiquinol-cytochrome c reductase core protein 1

increases expression

EXP

oxybenzone results in increased expression of UQCRC1 mRNA

NCBI chr 8:118,468,223...118,479,968
Ensembl chr 8:118,468,200...118,479,964

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

decreases expression

EXP

oxybenzone results in decreased expression of UQCRFS1 mRNA

NCBI chr17:34,173,787...34,190,952
Ensembl chr17:34,173,833...34,190,950

G

ubiquinol-cytochrome c reductase, complex III subunit VII

increases expression

EXP

oxybenzone results in increased expression of UQCRQ mRNA

NCBI chr10:38,086,691...38,093,871
Ensembl chr10:38,087,715...38,089,996

G

voltage-dependent anion channel 1

decreases expression

EXP

oxybenzone results in decreased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

vascular endothelial growth factor A

multiple interactions
decreases expression

ISO

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of VEGFA mRNA
oxybenzone results in decreased expression of VEGFA mRNA

PMID:38387520 PMID:39343157

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WAP four-disulfide core domain 21

decreases expression

EXP

oxybenzone results in decreased expression of WFDC21 mRNA

NCBI chr10:69,125,336...69,131,205
Ensembl chr10:69,125,320...69,131,201

G

Wnt family member 4

decreases expression

ISO

oxybenzone results in decreased expression of WNT4 mRNA

NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128

G

Wnt family member 5A

decreases expression

ISO

oxybenzone results in decreased expression of WNT5A mRNA

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860

G

WRN RecQ like helicase

increases expression

ISO

oxybenzone results in increased expression of WRN mRNA

NCBI chr16:65,466,552...65,602,951
Ensembl chr16:65,456,254...65,602,951

G

X-box binding protein 1

decreases expression

ISO

oxybenzone results in decreased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

zinc finger E-box binding homeobox 1

increases expression

ISO

oxybenzone results in increased expression of ZEB1 mRNA

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745

G

zinc finger protein 420

increases expression

ISO

oxybenzone results in increased expression of ZNF420 mRNA

NCBI chr 1:94,259,715...94,271,102
Ensembl chr 1:94,259,809...94,271,101

phenyl salicylate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

increases activity
multiple interactions

ISO

phenyl salicylate results in increased activity of ESR1 protein
phenyl salicylate binds to and results in increased activity of ESR1 protein

PMID:22197706 PMID:24004914

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
chemical role	20219
photochemical role	412
ultraviolet filter	383
1-feruloyl-sn-glycerol	0
esculetin	55
oxybenzone	338
phenyl salicylate	1
scytonemin	0
shinorine	0

paths to the root