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ONTOLOGY REPORT - ANNOTATIONS


Term:WIN 55212-2
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Accession:CHEBI:73295 term browser browse the term
Definition:A organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group.
Synonyms:exact_synonym: [(3R)-5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl](1-naphthyl)methanone
 related_synonym: (2,3-Dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone;   Formula=C27H26N2O3;   InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1;   InChIKey=HQVHOQAKMCMIIM-HXUWFJFHSA-N;   SMILES=Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23;   Win 55,212
 xref: CAS:131543-22-1 "ChemIDplus";   LINCS:LSM-15494
 xref_mesh: MESH:C070417
 xref: PMID:14512703 "Europe PMC";   PMID:15888960 "Europe PMC";   PMID:17306870 "Europe PMC";   PMID:19883712 "Europe PMC";   PMID:20158615 "Europe PMC";   PMID:20307280 "Europe PMC";   PMID:20969930 "Europe PMC";   PMID:21055447 "Europe PMC";   PMID:21057002 "Europe PMC";   PMID:21091643 "Europe PMC";   PMID:21130785 "Europe PMC";   PMID:21585053 "Europe PMC";   PMID:21909954 "Europe PMC";   PMID:23454099 "Europe PMC";   PMID:23558540 "Europe PMC";   PMID:23597562 "Europe PMC";   Patent:US2002182159;   Patent:US2003049220;   Patent:US2010215759;   Reaxys:4913623 "Reaxys";   Wikipedia:WIN_55\,212-2


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WIN 55212-2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cct7 chaperonin containing TCP1 subunit 7 JBrowse link 4 117,235,023 117,252,265 RGD:6480464
G Cdk14 cyclin-dependent kinase 14 JBrowse link 4 25,825,567 26,419,443 RGD:6480464
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:6480464
G Cnr1 cannabinoid receptor 1 JBrowse link 5 49,307,584 49,333,064 RGD:6480464
G Cnr2 cannabinoid receptor 2 JBrowse link 5 154,242,010 154,268,126 RGD:6480464
G Cnrip1 cannabinoid receptor interacting protein 1 JBrowse link 14 100,217,547 100,247,235 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Efs embryonal Fyn-associated substrate JBrowse link 15 33,579,952 33,590,217 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Eif4b eukaryotic translation initiation factor 4B JBrowse link 7 143,679,656 143,701,452 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Faah fatty acid amide hydrolase JBrowse link 5 134,852,899 134,872,095 RGD:6480464
G Faahl fatty-acid amide hydrolase-like JBrowse link 5 134,330,204 134,349,400 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6480464
G Hspb3 heat shock protein family B (small) member 3 JBrowse link 2 45,517,788 45,518,502 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Mat2a methionine adenosyltransferase 2A JBrowse link 4 100,297,478 100,303,047 RGD:6480464
G Mgll monoglyceride lipase JBrowse link 4 120,671,436 120,773,458 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Morf4l1 mortality factor 4 like 1 JBrowse link 8 97,473,454 97,494,974 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Ndrg4 NDRG family member 4 JBrowse link 19 9,766,439 9,802,396 RGD:6480464
G Nedd4l NEDD4 like E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:6480464
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:6480464
G Ntn1 netrin 1 JBrowse link 10 54,761,925 54,982,072 RGD:6480464
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6480464
G Pacsin1 protein kinase C and casein kinase substrate in neurons 1 JBrowse link 20 7,241,248 7,286,702 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Perp PERP, TP53 apoptosis effector JBrowse link 1 14,224,392 14,236,838 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:6480464
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:6480464
G Ptprn protein tyrosine phosphatase, receptor type, N JBrowse link 9 82,446,626 82,462,314 RGD:6480464
G Rfc1 replication factor C subunit 1 JBrowse link 14 44,627,528 44,702,205 RGD:6480464
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6480464
G Rtn3 reticulon 3 JBrowse link 1 222,677,359 222,734,307 RGD:6480464
G S1pr3 sphingosine-1-phosphate receptor 3 JBrowse link 17 13,799,383 13,812,877 RGD:6480464
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:6480464
G Slc1a1 solute carrier family 1 member 1 JBrowse link 1 246,955,017 247,035,159 RGD:6480464
G Slc1a2 solute carrier family 1 member 2 JBrowse link 3 92,518,679 92,665,731 RGD:6480464
G Smn1 survival of motor neuron 1, telomeric JBrowse link 2 30,360,101 30,371,147 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tagln3 transgelin 3 JBrowse link 11 60,072,983 60,086,552 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Traf5 TNF receptor-associated factor 5 JBrowse link 13 110,758,556 110,801,871 RGD:6480464
G Trib3 tribbles pseudokinase 3 JBrowse link 3 147,814,056 147,819,650 RGD:6480464
G Trim8 tripartite motif-containing 8 JBrowse link 1 266,255,797 266,270,694 RGD:6480464
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 JBrowse link 5 3,783,247 3,836,485 RGD:6480464
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 JBrowse link 10 59,799,123 59,824,208 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Vps26c VPS26 endosomal protein sorting factor C JBrowse link 11 34,764,053 34,792,446 RGD:6480464
G Wdr47 WD repeat domain 47 JBrowse link 2 211,380,894 211,441,817 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464
G Znrf1 zinc and ring finger 1 JBrowse link 19 43,750,205 43,834,962 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          analgesic 13037
            WIN 55212-2 78
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            organic hydride 17528
                              organic fundamental parent 17528
                                hydrocarbon 16935
                                  cyclic hydrocarbon 15098
                                    arene 15085
                                      aryl group 650
                                        naphthyl group 78
                                          naphthyl ketone 78
                                            WIN 55212-2 78
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.