Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:WIN 55212-2
go back to main search page
Accession:CHEBI:73295 term browser browse the term
Definition:A organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group.
Synonyms:exact_synonym: [(3R)-5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl](1-naphthyl)methanone
 related_synonym: (2,3-Dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone;   Formula=C27H26N2O3;   InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1;   InChIKey=HQVHOQAKMCMIIM-HXUWFJFHSA-N;   SMILES=Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23;   Win 55,212
 xref: CAS:131543-22-1;   LINCS:LSM-15494
 xref_mesh: MESH:C070417
 xref: PMID:14512703;   PMID:15888960;   PMID:17306870;   PMID:19883712;   PMID:20158615;   PMID:20307280;   PMID:20969930;   PMID:21055447;   PMID:21057002;   PMID:21091643;   PMID:21130785;   PMID:21585053;   PMID:21909954;   PMID:23454099;   PMID:23558540;   PMID:23597562;   Patent:US2002182159;   Patent:US2003049220;   Patent:US2010215759;   Reaxys:4913623;   Wikipedia:WIN_55\,212-2


show annotations for term's descendants           Sort by:
 
WIN 55212-2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 decreases expression ISO Win 55212-2 results in decreased expression of ABCA2 mRNA CTD PMID:12237329 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects activity ISO Win 55212-2 affects the activity of ABCG2 protein CTD PMID:30083819 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Adora2a adenosine A2a receptor decreases response to substance EXP ADORA2A protein results in decreased susceptibility to Win 55212-2 CTD PMID:26526685 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Win 55212-2 results in increased phosphorylation of AKT1 protein
CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of AKT1 protein]; Win 55212-2 results in increased phosphorylation of and results in increased activity of AKT1 protein
CTD PMID:12734338, PMID:20619260 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO Win 55212-2 results in decreased expression of APAF1 protein CTD PMID:30776504 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Win 55212-2 inhibits the reaction [APP alternative form results in increased expression of IL6 mRNA] CTD PMID:21350020 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Win 55212-2 results in decreased expression of ARHGDIA mRNA CTD PMID:12237329 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Becn1 beclin 1 decreases expression ISO Win 55212-2 results in decreased expression of BECN1 protein CTD PMID:30776504 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 decreases cleavage ISO Win 55212-2 results in decreased cleavage of CASP3 protein CTD PMID:30776504 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 decreases cleavage ISO Win 55212-2 results in decreased cleavage of CASP7 protein CTD PMID:30776504 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 decreases cleavage ISO Win 55212-2 results in decreased cleavage of CASP8 protein CTD PMID:30776504 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO AM 281 inhibits the reaction [Win 55212-2 results in increased activity of CASP9 protein] CTD PMID:28495606 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Win 55212-2 results in decreased expression of CCT7 mRNA CTD PMID:12237329 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Cdk14 cyclin-dependent kinase 14 increases expression ISO Win 55212-2 results in increased expression of CDK14 mRNA CTD PMID:12237329 NCBI chr 4:25,825,567...26,419,443
Ensembl chr 4:25,825,567...26,419,127
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Win 55212-2 results in increased expression of CITED2 mRNA; Win 55212-2 results in increased expression of CITED2 protein CTD PMID:12237329 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
affects localization
increases activity
affects binding
ISO
EXP
CNR1 affects the reaction [Win 55212-2 results in increased activity of MAPK1 protein]; CNR1 affects the reaction [Win 55212-2 results in increased activity of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Win 55212-2 results in increased activity of CNR1]; Rimonabant inhibits the reaction [Win 55212-2 results in increased activity of CNR1]; Win 55212-2 binds to and results in increased activity of CNR1 protein; Win 55212-2 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]
Win 55212-2 affects the localization of CNR1 protein
[Rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Win 55212-2; [Win 55212-2 binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium]; CNR1 protein affects the reaction [Win 55212-2 inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]; Rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]; Win 55212-2 binds to and results in increased activity of CNR1 protein
[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in increased expression of FOS protein; CNRIP1 protein inhibits the reaction [Win 55212-2 affects the localization of CNR1 protein]; Win 55212-2 binds to and results in increased activity of CNR1 protein
Win 55212-2 binds to CNR1 protein
CTD PMID:8526880, PMID:10871313, PMID:12421626, PMID:12560108, PMID:16438957, PMID:17572696, PMID:21281698, PMID:22044209, PMID:22971837, PMID:27513693, PMID:30165669 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 affects response to substance
multiple interactions
affects binding
ISO
EXP
CNR2 gene SNP affects the susceptibility to Win 55212-2
ridaifen-B inhibits the reaction [Win 55212-2 binds to and results in increased activity of CNR2 protein]; Win 55212-2 binds to and results in increased activity of CNR2 protein; Win 55212-2 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]
Win 55212-2 binds to CNR2 protein
[SR 144528 binds to and results in decreased activity of CNR2 protein] which results in decreased susceptibility to Win 55212-2; CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of AKT1 protein]; CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Win 55212-2 binds to and results in increased activity of CNR2 protein
CTD PMID:10688601, PMID:12734338, PMID:17572696, PMID:20124950, PMID:21281698, PMID:21871882, PMID:22044209, PMID:22971837, PMID:29906493 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 multiple interactions ISO CNRIP1 protein inhibits the reaction [Win 55212-2 affects the localization of CNR1 protein] CTD PMID:27513693 NCBI chr14:100,217,547...100,247,235
Ensembl chr14:100,217,289...100,247,235
JBrowse link
G Ctsd cathepsin D increases expression ISO Win 55212-2 results in increased expression of CTSD protein CTD PMID:30776504 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Win 55212-2 results in increased expression of DDIT3 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Win 55212-2 results in increased expression of DDIT3 mRNA] CTD PMID:30502353 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Efs embryonal Fyn-associated substrate decreases expression ISO Win 55212-2 results in decreased expression of EFS mRNA CTD PMID:12237329 NCBI chr15:33,579,952...33,590,217
Ensembl chr15:33,578,381...33,589,522
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO RTKI cpd inhibits the reaction [Win 55212-2 results in increased phosphorylation of EGFR protein] CTD PMID:20619260 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B decreases expression ISO Win 55212-2 results in decreased expression of EIF4B mRNA CTD PMID:12237329 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Win 55212-2 inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; Win 55212-2 inhibits the reaction [IL1B protein results in increased expression of F3 mRNA] CTD PMID:27556861 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions ISO [Acetaminophen co-treated with Win 55212-2] results in decreased expression of FAAH mRNA CTD PMID:30165669 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like multiple interactions ISO [Acetaminophen co-treated with Win 55212-2] results in decreased expression of FAAH mRNA CTD PMID:30165669 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in increased expression of FOS protein CTD PMID:12560108 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gck glucokinase increases expression ISO Win 55212-2 results in increased expression of GCK mRNA; Win 55212-2 results in increased expression of GCK protein CTD PMID:12237329 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gphn gephyrin multiple interactions EXP Win 55212-2 promotes the reaction [Cocaine results in increased phosphorylation of GPHN protein] CTD PMID:32312805 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression EXP Win 55212-2 results in decreased expression of GRIA1 protein CTD PMID:32312805 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Win 55212-2 results in decreased expression of GRIA2 protein CTD PMID:32312805 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions EXP Win 55212-2 promotes the reaction [Cocaine results in decreased expression of HDAC6 protein] CTD PMID:32312805 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Hspb3 heat shock protein family B (small) member 3 increases expression ISO Win 55212-2 results in increased expression of HSPB3 mRNA CTD PMID:12237329 NCBI chr 2:45,517,788...45,518,502
Ensembl chr 2:45,517,789...45,518,502
JBrowse link
G Htatsf1 HIV-1 Tat specific factor 1 multiple interactions EXP [Win 55212-2 co-treated with Cocaine] results in decreased phosphorylation of HTATSF1 protein CTD PMID:32312805 NCBI chr  X:159,514,053...159,528,281
Ensembl chr  X:159,513,800...159,528,281
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Win 55212-2 inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine]; Win 55212-2 inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; Win 55212-2 inhibits the reaction [IL1B protein results in increased expression of F3 mRNA] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Win 55212-2 inhibits the reaction [APP alternative form results in increased expression of IL6 mRNA] CTD PMID:21350020 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO fumonisin B1 inhibits the reaction [Win 55212-2 results in decreased phosphorylation of and results in decreased activity of KDR protein]; Win 55212-2 results in decreased phosphorylation of and results in decreased activity of KDR protein CTD PMID:15313899 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression ISO Win 55212-2 results in decreased expression of MAP2 mRNA CTD PMID:12237329 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity
increases phosphorylation
ISO
EXP
CNR1 affects the reaction [Win 55212-2 results in increased activity of MAPK1 protein]
CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Win 55212-2 promotes the reaction [Cocaine results in increased expression of MAPK1 protein]; Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK1 protein
Win 55212-2 results in increased phosphorylation of MAPK1 protein
CTD PMID:8526880, PMID:12657697, PMID:12734338, PMID:20619260, PMID:32312805 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
multiple interactions
increases phosphorylation
ISO
EXP
Win 55212-2 results in increased activity of MAPK3 protein
CNR2 protein affects the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Win 55212-2 promotes the reaction [Cocaine results in increased expression of MAPK3 protein]; Win 55212-2 results in increased phosphorylation of and results in increased activity of MAPK3 protein
Win 55212-2 results in increased phosphorylation of MAPK3 protein
CNR1 affects the reaction [Win 55212-2 results in increased activity of MAPK3 protein]
CTD PMID:8526880, PMID:12657697, PMID:12734338, PMID:20619260, PMID:32312805 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Win 55212-2 results in increased phosphorylation of MAPK8 protein CTD PMID:20619260 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Win 55212-2 results in increased phosphorylation of MAPK9 protein CTD PMID:20619260 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO Win 55212-2 results in increased expression of MAPT mRNA CTD PMID:12237329 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO Win 55212-2 results in decreased expression of MAT2A mRNA CTD PMID:12237329 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Mgll monoglyceride lipase affects response to substance ISO MGLL protein affects the susceptibility to Win 55212-2 CTD PMID:21911610 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Win 55212-2 results in decreased activity of MMP2 protein CTD PMID:30776504 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO Win 55212-2 results in decreased activity of MMP9 protein CTD PMID:30776504 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Morf4l1 mortality factor 4 like 1 decreases expression ISO Win 55212-2 results in decreased expression of MORF4L1 mRNA CTD PMID:12237329 NCBI chr 8:97,473,454...97,494,974
Ensembl chr 8:97,474,092...97,494,834
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Win 55212-2 results in increased expression of MYC mRNA CTD PMID:12237329 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ndrg4 NDRG family member 4 decreases expression ISO Win 55212-2 results in decreased expression of NDRG4 mRNA CTD PMID:12237329 NCBI chr19:9,766,439...9,802,396
Ensembl chr19:9,766,439...9,801,942
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase decreases expression ISO Win 55212-2 results in decreased expression of NEDD4L mRNA CTD PMID:12237329 NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 increases localization EXP Win 55212-2 results in increased localization of NFATC4 protein CTD PMID:16849427 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions EXP Win 55212-2 promotes the reaction [Cocaine results in increased splicing of NPAS2 mRNA] CTD PMID:32312805 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Ntn1 netrin 1 increases expression ISO Win 55212-2 results in increased expression of NTN1 mRNA CTD PMID:12237329 NCBI chr10:54,761,925...54,982,072
Ensembl chr10:54,761,871...54,967,585
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Acetaminophen co-treated with Win 55212-2] results in decreased expression of NTRK2 mRNA CTD PMID:30165669 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Pacsin1 protein kinase C and casein kinase substrate in neurons 1 decreases expression ISO Win 55212-2 results in decreased expression of PACSIN1 mRNA CTD PMID:12237329 NCBI chr20:7,241,248...7,286,702
Ensembl chr20:7,279,820...7,286,586
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Win 55212-2 results in decreased expression of PARP1 protein CTD PMID:30776504 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Win 55212-2 results in increased expression of PERP mRNA CTD PMID:12237329 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Win 55212-2 binds to and results in increased activity of PPARA protein CTD PMID:17906680 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression ISO Win 55212-2 results in decreased expression of PPP2R1A mRNA CTD PMID:12237329 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression ISO Win 55212-2 results in decreased expression of PTGDS mRNA CTD PMID:12237329 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N decreases expression ISO Win 55212-2 results in decreased expression of PTPRN mRNA CTD PMID:12237329 NCBI chr 9:82,446,626...82,462,314
Ensembl chr 9:82,446,633...82,461,903
JBrowse link
G Rfc1 replication factor C subunit 1 increases expression ISO Win 55212-2 results in increased expression of RFC1 mRNA CTD PMID:12237329 NCBI chr14:44,627,528...44,702,205
Ensembl chr14:44,580,216...44,702,203
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO Win 55212-2 results in decreased expression of RIPK1 protein CTD PMID:30776504 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Rtn3 reticulon 3 decreases expression ISO Win 55212-2 results in decreased expression of RTN3 mRNA CTD PMID:12237329 NCBI chr 1:222,677,359...222,734,307
Ensembl chr 1:222,677,365...222,734,241
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 increases expression ISO Win 55212-2 results in increased expression of S1PR3 mRNA CTD PMID:12237329 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Serpine2 serpin family E member 2 decreases expression ISO Win 55212-2 results in decreased expression of SERPINE2 mRNA CTD PMID:12237329 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP Win 55212-2 results in increased expression of SLC1A1 protein CTD PMID:17631920 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression EXP Win 55212-2 results in increased expression of SLC1A2 protein CTD PMID:17631920 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Smn1 survival of motor neuron 1, telomeric decreases expression ISO Win 55212-2 results in decreased expression of SMN1 mRNA CTD PMID:12237329 NCBI chr 2:30,360,101...30,371,147
Ensembl chr 2:30,360,100...30,371,147
JBrowse link
G Syp synaptophysin multiple interactions ISO [Acetaminophen co-treated with Win 55212-2] results in decreased expression of SYP mRNA CTD PMID:30165669 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tagln3 transgelin 3 decreases expression ISO Win 55212-2 results in decreased expression of TAGLN3 mRNA CTD PMID:12237329 NCBI chr11:60,072,983...60,086,552
Ensembl chr11:60,072,727...60,086,553
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Win 55212-2 inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein] CTD PMID:12509806 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Win 55212-2 results in increased expression of TP53 protein CTD PMID:30776504 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf5 TNF receptor-associated factor 5 increases expression ISO Win 55212-2 results in increased expression of TRAF5 mRNA CTD PMID:12237329 NCBI chr13:110,758,556...110,801,871
Ensembl chr13:110,758,761...110,784,209
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Win 55212-2 results in increased expression of TRIB3 protein CTD PMID:16818650 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim8 tripartite motif-containing 8 increases expression ISO Win 55212-2 results in increased expression of TRIM8 mRNA CTD PMID:12237329 NCBI chr 1:266,255,797...266,270,694
Ensembl chr 1:266,255,797...266,270,694
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases response to substance
EXP
ISO
TRPA1 promotes the reaction [Win 55212-2 results in increased abundance of Calcium]; Win 55212-2 binds to and results in increased activity of TRPA1 protein
TRPA1 results in increased susceptibility to Win 55212-2
CTD PMID:18234885, PMID:18550765 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
decreases phosphorylation
EXP Win 55212-2 binds to and results in increased activity of TRPV1 protein
Win 55212-2 results in decreased phosphorylation of TRPV1 protein
CTD PMID:16849427, PMID:18550765 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Win 55212-2 results in decreased expression of and results in decreased secretion of VEGFA protein
fumonisin B1 inhibits the reaction [Win 55212-2 results in decreased expression of and results in decreased secretion of VEGFA protein]; rimonabant inhibits the reaction [Win 55212-2 results in decreased expression of and results in decreased secretion of VEGFA protein]; SR 144528 inhibits the reaction [Win 55212-2 results in decreased expression of and results in decreased secretion of VEGFA protein]; Win 55212-2 results in decreased expression of and results in decreased secretion of VEGFA protein
CTD PMID:15313899 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C increases expression ISO Win 55212-2 results in increased expression of VPS26C mRNA CTD PMID:12237329 NCBI chr11:34,764,053...34,792,446
Ensembl chr11:34,764,721...34,791,993
JBrowse link
G Wdr47 WD repeat domain 47 decreases expression ISO Win 55212-2 results in decreased expression of WDR47 mRNA CTD PMID:12237329 NCBI chr 2:211,380,894...211,441,817
Ensembl chr 2:211,381,036...211,441,815
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Win 55212-2 results in decreased expression of XIAP protein CTD PMID:30776504 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Znrf1 zinc and ring finger 1 increases expression ISO Win 55212-2 results in increased expression of ZNRF1 mRNA CTD PMID:12237329 NCBI chr19:43,750,205...43,834,962
Ensembl chr19:43,750,278...43,832,878
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        pharmacological role 18793
          analgesic 13061
            WIN 55212-2 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    arene 17058
                                      aryl group 727
                                        naphthyl group 84
                                          naphthyl ketone 84
                                            WIN 55212-2 84
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.