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ONTOLOGY REPORT - ANNOTATIONS


Term:PK-11195
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Accession:CHEBI:73290 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Synonyms:exact_synonym: N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
 related_synonym: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide;   Formula=C21H21ClN2O;   InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3;   InChIKey=RAVIZVQZGXBOQO-UHFFFAOYSA-N;   PK11195;   RP 52028;   SMILES=CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
 xref: Beilstein:4264456 "ChemIDplus";   CAS:85532-75-8 "ChemIDplus";   LINCS:LSM-1532
 xref_mesh: MESH:C037850
 xref: PMID:22528948 "Europe PMC";   PMID:23358477 "Europe PMC";   PMID:23597562 "Europe PMC";   PMID:23611861 "Europe PMC";   Reaxys:4264456 "Reaxys";   Wikipedia:PK-11195


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PK-11195 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAD BCL2 associated agonist of cell death JBrowse link 11 64,269,828 64,284,704 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G BCL2L1 BCL2 like 1 JBrowse link 20 31,664,452 31,723,963 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 JBrowse link 19 40,991,282 41,018,398 RGD:6480464
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 JBrowse link 7 99,756,967 99,784,184 RGD:6480464
G GRIP1 glutamate receptor interacting protein 1 JBrowse link 12 66,347,431 67,069,265 RGD:6480464
G IL24 interleukin 24 JBrowse link 1 206,897,404 206,904,139 RGD:6480464
G NCOA1 nuclear receptor coactivator 1 JBrowse link 2 24,491,254 24,770,702 RGD:6480464
G NCOR1 nuclear receptor corepressor 1 JBrowse link 17 16,029,157 16,216,475 RGD:6480464
G NR1I2 nuclear receptor subfamily 1 group I member 2 JBrowse link 3 119,780,484 119,818,485 RGD:6480464
G NR1I3 nuclear receptor subfamily 1 group I member 3 JBrowse link 1 161,229,666 161,238,623 RGD:6480464
G RXRA retinoid X receptor alpha JBrowse link 9 134,326,455 134,440,586 RGD:6480464
G SRC SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 20 37,344,685 37,405,432 RGD:6480464
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:6480464
G TSPO translocator protein JBrowse link 22 43,151,559 43,163,242 RGD:6480464

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  CHEBI ontology 23680
    role 23568
      application 22948
        pharmaceutical 22486
          drug 22486
            antineoplastic agent 18532
              PK-11195 17
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  CHEBI ontology 23680
    subatomic particle 23627
      composite particle 23627
        hadron 23627
          baryon 23627
            nucleon 23627
              atomic nucleus 23627
                atom 23627
                  main group element atom 23444
                    p-block element atom 23444
                      carbon group element atom 23143
                        carbon atom 23119
                          organic molecular entity 23119
                            organic group 21817
                              organic divalent group 21786
                                organodiyl group 21786
                                  carbonyl group 21758
                                    carbonyl compound 21758
                                      carboxylic acid 20783
                                        carboacyl group 18723
                                          univalent carboacyl group 18723
                                            carbamoyl group 18042
                                              carboxamide 18042
                                                monocarboxylic acid amide 14132
                                                  PK-11195 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.