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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PK-11195
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Accession:CHEBI:73290 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Synonyms:exact_synonym: N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
 related_synonym: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide;   Formula=C21H21ClN2O;   InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3;   InChIKey=RAVIZVQZGXBOQO-UHFFFAOYSA-N;   PK11195;   RP 52028;   SMILES=CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
 xref: Beilstein:4264456;   CAS:85532-75-8;   LINCS:LSM-1532
 xref_mesh: MESH:C037850
 xref: PMID:22528948;   PMID:23358477;   PMID:23597562;   PMID:23611861;   Reaxys:4264456;   Wikipedia:PK-11195


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PK-11195 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death decreases phosphorylation
decreases expression
EXP PK 11195 results in decreased phosphorylation of BAD protein
PK 11195 results in decreased expression of BAD protein
CTD PMID:11266385 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO PK 11195 results in increased expression of BAX protein CTD PMID:15519653 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to alachlor]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Antimycin A]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to mesoxalonitrile]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to pyridaben]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Rotenone]
PK 11195 results in decreased expression of BCL2
PK 11195 results in decreased expression of BCL2 protein
CTD PMID:11266385, PMID:12730627, PMID:15519653 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO PK 11195 results in decreased expression of BCL2L1 protein CTD PMID:15519653 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity ISO PK 11195 results in increased activity of CASP3 protein CTD PMID:15519653 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO PK 11195 results in increased expression of CYP2B6 mRNA CTD PMID:21315811 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Grip1 glutamate receptor interacting protein 1 multiple interactions ISO PK 11195 inhibits the reaction [GRIP1 protein binds to NR1I3 protein] CTD PMID:24224465 NCBI chr 7:64,672,723...64,854,939
Ensembl chr 7:64,672,722...64,864,404
JBrowse link
G Il24 interleukin 24 increases activity ISO PK 11195 results in increased activity of IL24 protein CTD PMID:14678967 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO PK 11195 inhibits the reaction [NR1I3 protein binds to NCOA1 protein] CTD PMID:23665929 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO PK 11195 promotes the reaction [NR1I3 protein binds to NCOR1 protein] CTD PMID:23665929 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [PK 11195 co-treated with RXRA] results in increased activity of NR1I2 protein; PK 11195 inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]
PK 11195 results in increased activity of NR1I2 protein
CTD PMID:21315811, PMID:26187274 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity
ISO 1,5-benzothiazepine analog inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 4-nonylphenol inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine promotes the reaction [PK 11195 results in decreased activity of NR1I3 protein]; [4-ethylphenol co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; [Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form; [Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; PK 11195 binds to and results in decreased activity of NR1I3 protein; PK 11195 binds to and results in increased activity of NR1I3 protein mutant form; PK 11195 inhibits the reaction [GRIP1 protein binds to NR1I3 protein]; PK 11195 inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; PK 11195 inhibits the reaction [SRC protein binds to NR1I3 protein]; PK 11195 promotes the reaction [NR1I3 protein binds to NCOR1 protein]; PK 11195 results in decreased susceptibility to [3-pentadecylphenol binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in decreased susceptibility to [4,4'-bisphenol F binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in decreased susceptibility to [4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in decreased susceptibility to [resveratrol binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in increased susceptibility to [Terphenyl Compounds binds to and results in increased activity of NR1I3 protein alternative form] CTD PMID:20686338, PMID:20869355, PMID:21315811, PMID:23665929, PMID:24224465, PMID:25625231, PMID:28289823, PMID:30582956 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [PK 11195 co-treated with RXRA] results in increased activity of NR1I2 protein; PK 11195 inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein] CTD PMID:21315811 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO PK 11195 inhibits the reaction [SRC protein binds to NR1I3 protein] CTD PMID:24224465 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO PK 11195 inhibits the reaction [Rotenone affects the localization of TRP53 protein] CTD PMID:23899557 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tspo translocator protein affects binding
affects response to substance
multiple interactions
ISO
EXP
PK 11195 binds to TSPO protein
TSPO protein affects the susceptibility to PK 11195
9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [PK 11195 binds to TSPO protein]
CTD PMID:11266385, PMID:15519653, PMID:16495062, PMID:21037200, PMID:21790126, PMID:27639427 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              PK-11195 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  PK-11195 16
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