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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PK-11195
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Accession:CHEBI:73290 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Synonyms:exact_synonym: N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
 related_synonym: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide;   Formula=C21H21ClN2O;   InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3;   InChIKey=RAVIZVQZGXBOQO-UHFFFAOYSA-N;   PK11195;   RP 52028;   SMILES=CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
 xref: Beilstein:4264456;   CAS:85532-75-8;   LINCS:LSM-1532
 xref_mesh: MESH:C037850
 xref: PMID:22528948;   PMID:23358477;   PMID:23597562;   PMID:23611861;   Reaxys:4264456;   Wikipedia:PK-11195


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PK-11195 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death decreases phosphorylation
decreases expression
EXP PK 11195 results in decreased phosphorylation of BAD protein
PK 11195 results in decreased expression of BAD protein
CTD PMID:11266385 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO PK 11195 results in increased expression of BAX protein CTD PMID:15519653 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to alachlor]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Antimycin A]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to mesoxalonitrile]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to pyridaben]; PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Rotenone]
PK 11195 results in decreased expression of BCL2
PK 11195 results in decreased expression of BCL2 protein
CTD PMID:11266385 PMID:12730627 PMID:15519653 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO PK 11195 results in decreased expression of BCL2L1 protein CTD PMID:15519653 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity ISO PK 11195 results in increased activity of CASP3 protein CTD PMID:15519653 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO PK 11195 results in increased expression of CYP2B6 mRNA CTD PMID:21315811 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO PK 11195 results in increased expression of CYP3A4 mRNA CTD PMID:21315811 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Grip1 glutamate receptor interacting protein 1 multiple interactions ISO PK 11195 inhibits the reaction [GRIP1 protein binds to NR1I3 protein] CTD PMID:24224465 NCBI chr 7:54,934,856...55,592,274
Ensembl chr 7:54,934,250...55,592,273
JBrowse link
G Il24 interleukin 24 increases activity ISO PK 11195 results in increased activity of IL24 protein CTD PMID:14678967 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO PK 11195 inhibits the reaction [NR1I3 protein binds to NCOA1 protein] CTD PMID:23665929 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO PK 11195 promotes the reaction [NR1I3 protein binds to NCOR1 protein] CTD PMID:23665929 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [PK 11195 co-treated with RXRA] results in increased activity of NR1I2 protein; PK 11195 inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]
PK 11195 results in increased activity of NR1I2 protein
CTD PMID:21315811 PMID:26187274 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity
ISO 1,5-benzothiazepine analog inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 4-nonylphenol inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine promotes the reaction [PK 11195 results in decreased activity of NR1I3 protein]; [4-ethylphenol co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; [Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form; [Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; PK 11195 binds to and results in decreased activity of NR1I3 protein; PK 11195 binds to and results in increased activity of NR1I3 protein mutant form; PK 11195 inhibits the reaction [GRIP1 protein binds to NR1I3 protein]; PK 11195 inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; PK 11195 inhibits the reaction [SRC protein binds to NR1I3 protein]; PK 11195 promotes the reaction [NR1I3 protein binds to NCOR1 protein]; PK 11195 results in decreased susceptibility to [3-pentadecylphenol binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in decreased susceptibility to [4,4'-bisphenol F binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in decreased susceptibility to [4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in decreased susceptibility to [resveratrol binds to and results in increased activity of NR1I3 protein alternative form]; PK 11195 results in increased susceptibility to [Terphenyl Compounds binds to and results in increased activity of NR1I3 protein alternative form] CTD PMID:20686338 PMID:20869355 PMID:21315811 PMID:23665929 PMID:24224465 More... NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [PK 11195 co-treated with RXRA] results in increased activity of NR1I2 protein; PK 11195 inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein] CTD PMID:21315811 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO PK 11195 inhibits the reaction [SRC protein binds to NR1I3 protein] CTD PMID:24224465 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO PK 11195 inhibits the reaction [Rotenone affects the localization of TRP53 protein] CTD PMID:23899557 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tspo translocator protein affects binding
affects response to substance
multiple interactions
ISO
EXP
PK 11195 binds to TSPO protein
TSPO protein affects the susceptibility to PK 11195
9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [PK 11195 binds to TSPO protein]
CTD PMID:11266385 PMID:15519653 PMID:16495062 PMID:21037200 PMID:21790126 More... NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link

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  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            antineoplastic agent 17316
              PK-11195 17
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  PK-11195 17
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