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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ICI 118551
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Accession:CHEBI:73289 term browser browse the term
Definition:An indane substituted at position 7 by a methyl group and at position 4 by a 3-(isopropylamino)-2-hydroxybutoxy group (the 2R,3S-diastereomer).
Synonyms:exact_synonym: (2R,3S)-3-(isopropylamino)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]butan-2-ol
 related_synonym: Formula=C17H27NO2;   InChI=1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3/t13-,16-/m0/s1;   InChIKey=VFIDUCMKNJIJTO-BBRMVZONSA-N;   SMILES=CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
 xref_mesh: MESH:C026777
 xref: PMID:23597562;   Patent:WO2008075104;   Reaxys:18386360;   Wikipedia:ICI-118\,551



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ICI 118551 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ICI 118551 inhibits the reaction [Formoterol Fumarate results in decreased expression of ACTA2 protein] CTD PMID:21603974 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP
[ICI 118551 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; ICI 118551 binds to and results in decreased activity of ADRB1 protein; ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB1 protein]
[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 mRNA; [Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 protein; ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
CTD PMID:9260993 PMID:14730417 PMID:19719783 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects binding
ISO
EXP
[ICI 118551 binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine; [ICI 118551 co-treated with ADRB2 protein] results in increased expression of GNAS protein; [ICI 118551 co-treated with ADRB2 protein] results in increased expression of GRK2 protein; ICI 118551 binds to and results in decreased activity of ADRB2 protein; ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB2 protein]; ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]
[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which affects the uptake of Levodopa; ICI 118551 binds to and results in decreased activity of ADRB2 protein; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]; ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]; ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB2 protein]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]
ICI 118551 inhibits the reaction [[BRL 37344 binds to and results in increased activity of ADRB2 protein] which results in increased uptake of Glucose]; ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose]; ICI 118551 inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein]
CTD PMID:2462161 PMID:7969507 PMID:9260993 PMID:10344530 PMID:10372227 More... NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO
EXP
[ICI 118551 binds to and results in decreased activity of ADRB3 protein] which results in decreased abundance of Cyclic AMP; ICI 118551 binds to and results in decreased activity of ADRB3 protein; ICI 118551 binds to and results in increased activity of ADRB3 protein; ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB3 protein]
[Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 mRNA; [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 protein
CTD PMID:1682311 PMID:14730417 PMID:19719783 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Agt angiotensinogen multiple interactions ISO ICI 118551 inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]] CTD PMID:7843740 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]] CTD PMID:17925438 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [ICI 118551 co-treated with gemcitabine] results in increased expression of BAX protein CTD PMID:21570961 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [ICI 118551 co-treated with gemcitabine] results in decreased expression of BCL2 protein CTD PMID:21570961 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP capsazepine inhibits the reaction [ICI 118551 results in increased secretion of [CALCA protein co-treated with CALCB protein]]; ICI 118551 results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calcb calcitonin-related polypeptide, beta multiple interactions EXP capsazepine inhibits the reaction [ICI 118551 results in increased secretion of [CALCA protein co-treated with CALCB protein]]; ICI 118551 results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:168,966,465...168,970,125
Ensembl chr 1:168,966,465...168,970,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO ICI 118551 inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:22167199 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO ICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Gnas GNAS complex locus multiple interactions
increases expression
ISO [ICI 118551 co-treated with ADRB2 protein] results in increased expression of GNAS protein
ICI 118551 results in increased expression of GNAS protein
CTD PMID:10455254 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,136,350
Ensembl chr 3:163,071,417...163,136,350
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 increases expression
multiple interactions
ISO ICI 118551 results in increased expression of GRK2 protein
[ICI 118551 co-treated with ADRB2 protein] results in increased expression of GRK2 protein
CTD PMID:10455254 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Il18 interleukin 18 multiple interactions ISO ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]; ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 protein] CTD PMID:15178407 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il5 interleukin 5 multiple interactions ISO ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ICI 118551 inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ICI 118551 inhibits the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:9688336 PMID:10525314 PMID:11096136 PMID:12619890 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO ICI 118551 results in decreased activity of [KCNH2 protein binds to KCNH2 protein]
ICI 118551 results in decreased activity of KCNH2 protein
CTD PMID:15679475 PMID:16314852 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]
[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK1 protein; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]
CTD PMID:11675405 PMID:12608646 PMID:17003101 PMID:17925438 PMID:19719783 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]
[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK3 protein; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]
CTD PMID:11675405 PMID:12608646 PMID:17003101 PMID:17925438 PMID:19719783 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP [Dobutamine co-treated with ICI 118551] results in increased activity of MAPK9 protein CTD PMID:19719783 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases secretion
ISO ICI 118551 results in decreased expression of MMP2 mRNA; ICI 118551 results in decreased expression of MMP2 protein
ICI 118551 results in decreased secretion of MMP2 protein
CTD PMID:20424515 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases secretion
ISO ICI 118551 results in decreased expression of MMP9 mRNA; ICI 118551 results in decreased expression of MMP9 protein
ICI 118551 results in decreased secretion of MMP9 protein
CTD PMID:20424515 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO ICI 118551 results in decreased expression of PPARGC1A mRNA CTD PMID:17446185 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO ICI 118551 results in decreased expression of PTGS2 mRNA; ICI 118551 results in decreased expression of PTGS2 protein
[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]
CTD PMID:17003101 PMID:17369603 PMID:20424515 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO ICI 118551 inhibits the reaction [Albuterol results in decreased expression of RB1 protein] CTD PMID:16446544 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Ren renin multiple interactions ISO ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] CTD PMID:6314140 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]
ICI 118551 inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
CTD PMID:9688336 PMID:10525314 PMID:10857765 PMID:11096136 PMID:11675405 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO ICI 118551 results in decreased expression of VEGFA mRNA; ICI 118551 results in decreased expression of VEGFA protein CTD PMID:20424515 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        refrigerant 18086
          ammonia 17516
            organic amino compound 17516
              secondary amino compound 6640
                ICI 118551 30
Path 2
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  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    main group molecular entity 19948
                      s-block molecular entity 19735
                        hydrogen molecular entity 19727
                          hydrides 19093
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17767
                                  azane 17517
                                    ammonia 17516
                                      organic amino compound 17516
                                        secondary amino compound 6640
                                          ICI 118551 30
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