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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-methoxyidazoxan
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Accession:CHEBI:73287 term browser browse the term
Definition:A benzodioxine that is idazoxan substituted at position 2 by a methoxy group.
Synonyms:exact_synonym: 2-(2-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole
 related_synonym: 2-[2-(2-methoxy-1,4-benzodioxanyl)]imidazoline;   Formula=C12H14N2O3;   InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14);   InChIKey=HQGWKNGAKBPTBX-UHFFFAOYSA-N;   RX-821002;   SMILES=COC1(COc2ccccc2O1)C1=NCCN1;   alpha-methoxyidazoxan
 xref: CAS:102575-24-6;   LINCS:LSM-1714
 xref_mesh: MESH:C058525
 xref: PMID:11441427;   PMID:12177687;   PMID:1358860;   PMID:16697114;   PMID:1686202;   PMID:20504656;   PMID:22150679;   PMID:22373877;   PMID:22828637;   PMID:23597562;   PMID:8880071;   Reaxys:4296114


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2-methoxyidazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A affects binding
multiple interactions
ISO ADRA2A protein binds to 2-methoxyidazoxan
Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B affects binding
multiple interactions
ISO ADRA2B protein binds to 2-methoxyidazoxan
Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
affects binding
affects response to substance
ISO Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]
ADRA2C affects the susceptibility to 2-methoxyidazoxan
CTD PMID:10336518, PMID:20030735 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein] CTD PMID:17680988 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link

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  CHEBI ontology 19816
    role 19764
      biological role 19764
        pharmacological role 18825
          neurotransmitter agent 16439
            adrenergic agent 8951
              adrenergic antagonist 2318
                alpha-adrenergic antagonist 1999
                  2-methoxyidazoxan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteromonocyclic compound 16469
                                    diazoline 70
                                      imidazolines 70
                                        idazoxan 14
                                          2-methoxyidazoxan 4
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