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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-methoxyidazoxan
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Accession:CHEBI:73287 term browser browse the term
Definition:A benzodioxine that is idazoxan substituted at position 2 by a methoxy group.
Synonyms:exact_synonym: 2-(2-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole
 related_synonym: 2-[2-(2-methoxy-1,4-benzodioxanyl)]imidazoline;   Formula=C12H14N2O3;   InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14);   InChIKey=HQGWKNGAKBPTBX-UHFFFAOYSA-N;   RX-821002;   SMILES=COC1(COc2ccccc2O1)C1=NCCN1;   alpha-methoxyidazoxan
 xref: CAS:102575-24-6;   LINCS:LSM-1714
 xref_mesh: MESH:C058525
 xref: PMID:11441427;   PMID:12177687;   PMID:1358860;   PMID:16697114;   PMID:1686202;   PMID:20504656;   PMID:22150679;   PMID:22373877;   PMID:22828637;   PMID:23597562;   PMID:8880071;   Reaxys:4296114



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2-methoxyidazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A affects binding
multiple interactions
ISO ADRA2A protein binds to 2-methoxyidazoxan
Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2b adrenoceptor alpha 2B affects binding
multiple interactions
ISO ADRA2B protein binds to 2-methoxyidazoxan
Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
affects binding
affects response to substance
ISO Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]
ADRA2C affects the susceptibility to 2-methoxyidazoxan
CTD PMID:10336518 PMID:20030735 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein] CTD PMID:17680988 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link

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  CHEBI ontology 19800
    role 19751
      biological role 19751
        pharmacological role 18837
          neurotransmitter agent 16451
            adrenergic agent 9018
              adrenergic antagonist 2364
                alpha-adrenergic antagonist 2044
                  2-methoxyidazoxan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    diazoline 70
                                      imidazolines 70
                                        idazoxan 14
                                          2-methoxyidazoxan 4
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