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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:DPCPX
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Accession:CHEBI:73282 term browser browse the term
Definition:An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Synonyms:exact_synonym: 8-cyclopentyl-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione
 related_synonym: 1,3-Dipropyl-8-cyclopentylxanthine;   1,3-Dpcpx;   8-Cyclopentyl-1,3-dipropylxanthine;   CPX;   Formula=C16H24N4O2;   InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18);   InChIKey=FFBDFADSZUINTG-UHFFFAOYSA-N;   PD-116,948;   PD-116948;   SMILES=CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1CCCC1;   dipropylcyclopentylxanthine
 xref: CAS:102146-07-6;   KEGG:C13709;   LINCS:LSM-19971
 xref_mesh: MESH:C051360
 xref: PMID:23597562;   Patent:US2004259889;   Patent:US5470579;   Reaxys:4298634;   Wikipedia:Dipropylcyclopentylxanthine


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DPCPX term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]] CTD PMID:30031108 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
affects binding		 ISO
EXP		 1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein; [1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Oxygen deficiency; [1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in increased susceptibility to cobaltous chloride
1,3-dipropyl-8-cyclopentylxanthine binds to ADORA1 protein
1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; [1,3-dipropyl-8-cyclopentylxanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to 2-chloro-N(6)cyclopentyladenosine		 CTD PMID:10642308 PMID:10677590 PMID:11311893 PMID:15641640 PMID:18313046 More... NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adora2a adenosine A2a receptor multiple interactions
affects binding		 ISO 2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine inhibits the reaction [1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2A protein]; istradefylline inhibits the reaction [1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2A protein] CTD PMID:21210664 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Adora2b adenosine A2B receptor affects binding ISO 1,3-dipropyl-8-cyclopentylxanthine binds to ADORA2B protein CTD PMID:21186795 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]] CTD PMID:30031108 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Lep leptin multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of MAPK1 protein] CTD PMID:17293559 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of MAPK3 protein] CTD PMID:17293559 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nisch nischarin multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased expression of NOS2 protein] CTD PMID:10952960 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:15452191 PMID:19966059 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          antagonist 17233
            adenosine receptor antagonist 4092
              adenosine A1 receptor antagonist 18
                DPCPX 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      imidazopyrimidine 7756
                                        purines 7755
                                          aminopurine 6726
                                            2-aminopurines 6300
                                              guanine 6273
                                                xanthine 6192
                                                  7H-xanthine 3131
                                                    DPCPX 11
paths to the root