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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ospemifene
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Accession:CHEBI:73275 term browser browse the term
Definition:An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.
Synonyms:exact_synonym: 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}ethanol
 related_synonym: 2-(4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol;   2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol;   Deamino-hydroxytoremifene;   FC-1271a;   Fc-1271;   Formula=C24H23ClO2;   InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-;   InChIKey=LUMKNAVTFCDUIE-VHXPQNKSSA-N;   Osphena;   SMILES=OCCOc1ccc(cc1)C(\\c1ccccc1)=C(\\CCCl)c1ccccc1
 xref: CAS:128607-22-7;   Drug_Central:4749;   KEGG:D08958
 xref_mesh: MESH:C119141
 xref: PMID:10845810;   PMID:11457665;   PMID:19182697;   PMID:19466874;   PMID:19533603;   PMID:19857095;   PMID:20032798;   PMID:20073065;   PMID:20107426;   PMID:20429673;   PMID:20485909;   PMID:21564348;   PMID:21654612;   PMID:21926925;   PMID:22011753;   PMID:22196312;   PMID:23062036;   PMID:23096251;   PMID:23332519;   PMID:23361170;   Patent:CN101636372;   Patent:EP2275098;   Patent:EP2286806;   Patent:US2005182143;   Patent:US2005187301;   Patent:US2005187302;   Patent:US2008207956;   Patent:US2011015448;   Patent:WO2005105052;   Patent:WO2010107475;   Reaxys:10283864;   Wikipedia:Ospemifene


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ospemifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apod apolipoprotein D multiple interactions ISO Ospemifene inhibits the reaction [Estradiol results in decreased expression of APOD protein] CTD PMID:27163517 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
affects expression		 ISO [Ospemifene co-treated with Estradiol] results in decreased expression of AR protein
Ospemifene results in decreased expression of AR protein
Ospemifene affects the expression of AR mRNA		 CTD PMID:27163517 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein] CTD PMID:19533603 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions		 ISO Ospemifene results in decreased expression of ESR1 mRNA; Ospemifene results in decreased expression of ESR1 protein
Ospemifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]		 CTD PMID:27163517 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein] CTD PMID:19533603 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of RELA protein] CTD PMID:19533603 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tff1 trefoil factor 1 decreases expression
multiple interactions		 ISO Ospemifene results in decreased expression of TFF1 mRNA; Ospemifene results in decreased expression of TFF1 protein
Ospemifene inhibits the reaction [Estradiol results in increased expression of TFF1 protein]		 CTD PMID:27163517 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO Ospemifene results in increased expression of and results in increased secretion of TNFRSF11B protein CTD PMID:17420779 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      application 19732
        anti-inflammatory agent 16521
          ospemifene 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic molecule 19764
                              organic cyclic compound 19572
                                carbocyclic compound 18605
                                  benzenoid aromatic compound 17955
                                    benzenes 17803
                                      stilbene 3401
                                        ospemifene 8
paths to the root