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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ospemifene
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Accession:CHEBI:73275 term browser browse the term
Definition:An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.
Synonyms:exact_synonym: 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}ethanol
 related_synonym: 2-(4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol;   2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol;   Deamino-hydroxytoremifene;   FC-1271a;   Fc-1271;   Formula=C24H23ClO2;   InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-;   InChIKey=LUMKNAVTFCDUIE-VHXPQNKSSA-N;   Osphena;   SMILES=OCCOc1ccc(cc1)C(\\c1ccccc1)=C(\\CCCl)c1ccccc1
 xref: CAS:128607-22-7;   Drug_Central:4749;   KEGG:D08958
 xref_mesh: MESH:C119141
 xref: PMID:10845810;   PMID:11457665;   PMID:19182697;   PMID:19466874;   PMID:19533603;   PMID:19857095;   PMID:20032798;   PMID:20073065;   PMID:20107426;   PMID:20429673;   PMID:20485909;   PMID:21564348;   PMID:21654612;   PMID:21926925;   PMID:22011753;   PMID:22196312;   PMID:23062036;   PMID:23096251;   PMID:23332519;   PMID:23361170;   Patent:CN101636372;   Patent:EP2275098;   Patent:EP2286806;   Patent:US2005182143;   Patent:US2005187301;   Patent:US2005187302;   Patent:US2008207956;   Patent:US2011015448;   Patent:WO2005105052;   Patent:WO2010107475;   Reaxys:10283864;   Wikipedia:Ospemifene



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ospemifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein] CTD PMID:19533603 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein] CTD PMID:19533603 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of RELA protein] CTD PMID:19533603 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO Ospemifene results in increased expression of and results in increased secretion of TNFRSF11B protein CTD PMID:17420779 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        anti-inflammatory agent 16435
          ospemifene 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                carbocyclic compound 18521
                                  benzenoid aromatic compound 17760
                                    benzenes 17560
                                      stilbene 3370
                                        ospemifene 4
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