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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ospemifene
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Accession:CHEBI:73275 term browser browse the term
Definition:An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.
Synonyms:exact_synonym: 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}ethanol
 related_synonym: 2-(4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol;   2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol;   Deamino-hydroxytoremifene;   FC-1271a;   Fc-1271;   Formula=C24H23ClO2;   InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-;   InChIKey=LUMKNAVTFCDUIE-VHXPQNKSSA-N;   Osphena;   SMILES=OCCOc1ccc(cc1)C(\\c1ccccc1)=C(\\CCCl)c1ccccc1
 xref: CAS:128607-22-7;   Drug_Central:4749;   KEGG:D08958
 xref_mesh: MESH:C119141
 xref: PMID:10845810;   PMID:11457665;   PMID:19182697;   PMID:19466874;   PMID:19533603;   PMID:19857095;   PMID:20032798;   PMID:20073065;   PMID:20107426;   PMID:20429673;   PMID:20485909;   PMID:21564348;   PMID:21654612;   PMID:21926925;   PMID:22011753;   PMID:22196312;   PMID:23062036;   PMID:23096251;   PMID:23332519;   PMID:23361170;   Patent:CN101636372;   Patent:EP2275098;   Patent:EP2286806;   Patent:US2005182143;   Patent:US2005187301;   Patent:US2005187302;   Patent:US2008207956;   Patent:US2011015448;   Patent:WO2005105052;   Patent:WO2010107475;   Reaxys:10283864;   Wikipedia:Ospemifene


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ospemifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein] CTD PMID:19533603 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein] CTD PMID:19533603 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of RELA protein] CTD PMID:19533603 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO Ospemifene results in increased expression of and results in increased secretion of TNFRSF11B protein CTD PMID:17420779 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        anti-inflammatory agent 15771
          ospemifene 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                carbocyclic compound 18297
                                  benzenoid aromatic compound 17402
                                    benzenes 17174
                                      stilbene 3358
                                        ospemifene 4
paths to the root