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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:73274 term browser browse the term
Definition:A C-glycosyl compound that is used (in its hemihydrate form) for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol
 related_synonym: 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene;   Formula=C24H25FO5S;   InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1;   InChIKey=XTNGUQKDFGDXSJ-ZXGKGEBGSA-N;   SMILES=[C@@H]1([C@@H]([C@H]([C@@](O[C@@H]1CO)(C2=CC=C(C(=C2)CC=3SC(=CC3)C4=CC=C(C=C4)F)C)[H])O)O)O
 xref: CAS:842133-18-0;   Drug_Central:4758
 xref_mesh: MESH:D000068896
 xref: PMID:20690635;   PMID:21457428;   PMID:22226086;   PMID:22355316;   PMID:22385274;   PMID:22492586;   PMID:22548646;   PMID:22621689;   PMID:22632452;   PMID:23087012;   PMID:23279307;   PMID:23370138;   PMID:23412078;   PMID:23464594;   PMID:23563279;   PMID:23564919;   PMID:23585665;   PMID:23590413;   Patent:US2008146515;   Patent:US2010099883;   Patent:US2012289694;   Patent:WO2009035969;   Patent:WO2011142478;   Reaxys:18362681;   Wikipedia:Canagliflozin

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canagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Canagliflozin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:27566243 PMID:28837785 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression
multiple interactions
EXP Canagliflozin results in decreased expression of CHRM1 protein
Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
CTD PMID:28837785 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Canagliflozin results in increased expression of HAVCR1 CTD PMID:25130857 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Canagliflozin results in increased expression of LHB protein CTD PMID:25289773 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Pth parathyroid hormone decreases expression EXP Canagliflozin results in decreased expression of PTH protein CTD PMID:25289773 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO Canagliflozin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        inhibitor 18592
          sodium-glucose transport protein subtype 2 inhibitor 39
            canagliflozin 6
              canagliflozin hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11947
                                        glycosyl compound 10977
                                          C-glycosyl compound 258
                                            canagliflozin 6
                                              canagliflozin hydrate 0
paths to the root