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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:deglymidodrine
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Accession:CHEBI:73248 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states.
Synonyms:related_synonym: (+-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol;   1-(2',5'-dimethoxyphenyl)aminoethanol;   Formula=C10H15NO3;   InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3;   InChIKey=VFRCNXKYZVQYLX-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CN;   ST-1059;   alpha-(aminomethyl)-2,5-dimethoxybenzenemethanol;   de-glymidodrine;   desglymidodrine;   rac-2-amino-1-(2,5-dimethoxyphenyl)ethanol
 xref: CAS:3600-87-1;   PMID:15537169;   PMID:16242885;   PMID:23051063;   Reaxys:3262168


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midodrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Midodrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Midodrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        pharmacological role 19107
          neurotransmitter agent 16742
            adrenergic agent 9178
              sympathomimetic agent 5574
                deglymidodrine 2
                  midodrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    main group molecular entity 19867
                      s-block molecular entity 19697
                        hydrogen molecular entity 19686
                          hydrides 19161
                            inorganic hydride 18132
                              pnictogen hydride 18121
                                nitrogen hydride 18027
                                  azane 17828
                                    ammonia 17827
                                      organic amino compound 17827
                                        primary amino compound 9314
                                          deglymidodrine 2
                                            midodrine 2
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