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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(-)-noscapine
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Accession:CHEBI:73237 term browser browse the term
Definition:A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from plants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects.
Synonyms:exact_synonym: (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
 related_synonym: (-)-narcotine;   Formula=C22H23NO7;   InChI=1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1;   InChIKey=AKNNEGZIBPJZJG-MSOLQXFVSA-N;   SMILES=C1N([C@@](C2=C(C1)C=C3OCOC3=C2OC)([H])[C@@]4(C=5C=CC(=C(C5C(O4)=O)OC)OC)[H])C;   alpha-Narcotine;   noscapina;   noscapinum
 alt_id: CHEBI:10321
 xref: CAS:128-62-1;   Drug_Central:1973;   HMDB:HMDB0033439;   KEGG:C09592;   KEGG:D01036;   KNApSAcK:C00001891;   LINCS:LSM-3997
 xref_mesh: MESH:D009665
 xref: MetaCyc:CPD-14834;   PMID:22079300;   PMID:22546556;   PMID:22653730;   PMID:22671862;   PMID:22733149;   PMID:22848370;   PMID:22935070;   PMID:23117045;   Reaxys:99933;   Wikipedia:Noscapine


show annotations for term's descendants           Sort by:
(-)-noscapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP Noscapine promotes the reaction [Cisplatin results in increased expression of BAX protein]
Noscapine results in increased expression of BAX protein		 CTD PMID:20674069 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP Noscapine results in decreased expression of BCL2 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]		 CTD PMID:20674069 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases response to substance
decreases expression
multiple interactions
increases expression		 EXP BIRC5 protein results in decreased susceptibility to Noscapine
Noscapine results in decreased expression of BIRC5 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BIRC5 protein]
Noscapine results in increased expression of BIRC5 mRNA; Noscapine results in increased expression of BIRC5 protein		 CTD PMID:20674069 PMID:22848370 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP [Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP3 protein
Noscapine results in increased activity of CASP3 protein		 CTD PMID:20674069 PMID:22848370 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP9 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP9 protein CTD PMID:20674069 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein]
Noscapine results in increased expression of CDKN1A protein		 CTD PMID:20674069 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP Noscapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A protein CTD PMID:16596621 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Noscapine results in increased cleavage of PARP1 protein CTD PMID:22848370 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Noscapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression		 EXP Noscapine promotes the reaction [Cisplatin results in increased expression of TP53 protein]; Noscapine results in increased expression of and results in increased phosphorylation of TP53 protein
Noscapine results in increased expression of TP53 protein		 CTD PMID:20674069 PMID:22848370 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases secretion EXP Noscapine results in decreased secretion of VEGFA protein CTD PMID:16596621 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        biochemical role 25162
          apoptosis inducer 14998
            (-)-noscapine 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        tertiary amino compound 10427
                                          (-)-noscapine hemiacetal 12
                                            (-)-noscapine 12
paths to the root