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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:allyl isothiocyanate
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Accession:CHEBI:73224 term browser browse the term
Definition:An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
Synonyms:related_synonym: 2-propenyl isothiocyanate;   3-Isothiocyanato-1-propene;   3-Isothiocyanatoprop-1-ene;   AIT;   AITC;   Allylsenfoel;   Formula=C4H5NS;   InChI=1S/C4H5NS/c1-2-3-5-4-6/h2H,1,3H2;   InChIKey=ZOJBYZNEUISWFT-UHFFFAOYSA-N;   Mustard oil;   SMILES=C=CCN=C=S;   Senf oel;   allyl isosulfocyanate;   allyl mustard oil;   isothiocyanate d'allyle;   isothiocyanic acid allyl ester;   oil of mustard;   oleum sinapis;   volatile mustard oil;   volatile oil of mustard
 xref: CAS:57-06-7;   HMDB:HMDB0005843;   KEGG:C19317;   KEGG:D02818
 xref_mesh: MESH:C004471
 xref: PMID:20174640;   PMID:21237300;   PMID:21711355;   PMID:22093285;   PMID:22104119;   PMID:22131350;   PMID:22265303;   PMID:23008020;   PMID:23072699;   PMID:23212023;   PMID:23470258;   PMID:23535540;   PMID:23757176;   Reaxys:773748;   Wikipedia:Allyl_isothiocyanate



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allyl isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta decreases expression EXP allyl isothiocyanate results in decreased expression of ACTA2 mRNA CTD PMID:24036144 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP allyl isothiocyanate results in decreased expression of AGER mRNA CTD PMID:24036144 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of AIF1 protein] CTD PMID:27241356 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO allyl isothiocyanate results in decreased phosphorylation of AKT1 protein CTD PMID:37318315 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions ISO BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] CTD PMID:17571167 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496
JBrowse link
G Braf Braf transforming gene decreases phosphorylation ISO allyl isothiocyanate results in decreased phosphorylation of BRAF protein CTD PMID:37318315 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions
increases secretion
ISO safranal inhibits the reaction [allyl isothiocyanate results in increased secretion of CALCA protein] CTD PMID:30636360 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases cleavage
ISO AG 1879 inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein] CTD PMID:23219522 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase multiple interactions ISO allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:25744308 PMID:27241356 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO allyl isothiocyanate results in increased expression of CDKN1A mRNA CTD PMID:17937621 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression EXP allyl isothiocyanate results in decreased expression of COL1A1 mRNA CTD PMID:24036144 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions EXP
ISO
allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA]
allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]
CTD PMID:25069801 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO allyl isothiocyanate results in increased expression of GADD45A mRNA CTD PMID:17937621 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions
increases expression
EXP allyl isothiocyanate results in increased activity of GCLC protein
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]
CTD PMID:24036144 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of GPT protein]] CTD PMID:27241356 PMID:30927557 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO allyl isothiocyanate results in decreased expression of GRB2 protein CTD PMID:37318315 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423
JBrowse link
G Gsr glutathione reductase increases activity
decreases activity
multiple interactions
ISO allyl isothiocyanate results in increased activity of GSR protein
allyl isothiocyanate results in decreased activity of GSR protein
allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein]
CTD PMID:17937621 PMID:22664424 PMID:25744308 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 increases activity EXP allyl isothiocyanate results in increased activity of GSTA3 promoter CTD PMID:19232536 NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects metabolic processing ISO GSTM1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects metabolic processing ISO GSTP1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
multiple interactions
ISO
EXP
allyl isothiocyanate results in increased activity of HMOX1 protein
allyl isothiocyanate results in increased expression of HMOX1 mRNA; allyl isothiocyanate results in increased expression of HMOX1 protein
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
CTD PMID:22664424 PMID:23942037 PMID:27241356 PMID:34635025 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
JBrowse link
G Ins1 insulin I multiple interactions ISO allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of INS1 protein]] CTD PMID:30927557 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]
allyl isothiocyanate results in decreased phosphorylation of MAPK1 protein
CTD PMID:23219522 PMID:23994502 PMID:37318315 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO allyl isothiocyanate results in increased phosphorylation of MAPK3 protein
[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]
allyl isothiocyanate results in decreased phosphorylation of MAPK3 protein
CTD PMID:23219522 PMID:23994502 PMID:37318315 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO allyl isothiocyanate results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:37318315 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO allyl isothiocyanate results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:37318315 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric increases expression ISO allyl isothiocyanate results in increased expression of MUC5AC mRNA CTD PMID:31944254 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 increases expression ISO allyl isothiocyanate results in increased expression of NDRG1 mRNA CTD PMID:17937621 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
increases activity
ISO
EXP
allyl isothiocyanate results in increased expression of NFE2L2 protein
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to allyl isothiocyanate]
allyl isothiocyanate results in increased activity of NFE2L2 protein
allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]
CTD PMID:20932822 PMID:22664424 PMID:24036144 PMID:30927557 PMID:34635025 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases activity
increases expression
ISO allyl isothiocyanate results in increased activity of NQO1 protein
allyl isothiocyanate results in increased expression of NQO1 mRNA
CTD PMID:22664424 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]]
allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]
CTD PMID:25069801 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP
ISO
allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA]
allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]
CTD PMID:25069801 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide decreases expression EXP allyl isothiocyanate results in decreased expression of PDGFRB mRNA CTD PMID:24036144 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 multiple interactions ISO allyl isothiocyanate results in decreased expression of and results in decreased phosphorylation of PDPK1 protein CTD PMID:37318315 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO allyl isothiocyanate results in decreased expression of PLAU protein CTD PMID:37318315 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of PPARG protein] CTD PMID:30927557 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO allyl isothiocyanate results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:37318315 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO allyl isothiocyanate results in decreased expression of RHOA protein CTD PMID:37318315 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions ISO allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]] CTD PMID:30927557 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
JBrowse link
G Snai1 snail family zinc finger 1 decreases expression ISO allyl isothiocyanate results in decreased expression of SNAI1 protein CTD PMID:37318315 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO allyl isothiocyanate results in decreased expression of SOS1 protein CTD PMID:37318315 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Tac1 tachykinin 1 increases secretion ISO allyl isothiocyanate results in increased secretion of TAC1 protein CTD PMID:16725114 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:27241356 PMID:28483571 PMID:34635025 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO allyl isothiocyanate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:34635025 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
affects response to substance
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; [allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium; Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]; BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased uptake of Calcium]
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [TRPA1 protein results in increased susceptibility to sodium persulfate] which affects the susceptibility to allyl isothiocyanate; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein; Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gentamicins inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Indomethacin inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]
TRPA1 mRNA affects the susceptibility to allyl isothiocyanate; TRPA1 protein polymorphism affects the susceptibility to allyl isothiocyanate
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to allyl isothiocyanate
CTD PMID:15046718 PMID:15843607 PMID:17314320 PMID:17571167 PMID:17825279 More... NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases activity ISO allyl isothiocyanate results in increased activity of TRPM8 protein CTD PMID:29054683 NCBI chr 1:88,234,457...88,318,909
Ensembl chr 1:88,205,383...88,317,015
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases activity
EXP
ISO
TRPV1 affects the susceptibility to allyl isothiocyanate
allyl isothiocyanate results in increased activity of TRPV1 protein
CTD PMID:21430076 PMID:29054683 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity ISO allyl isothiocyanate results in decreased activity of TXNRD1 protein CTD PMID:17937621 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vim vimentin decreases expression ISO allyl isothiocyanate results in decreased expression of VIM protein CTD PMID:37318315 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        antimicrobial agent 19546
          allyl isothiocyanate 55
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organosulfur compound 18097
                                  isothiocyanate 3476
                                    alkenyl isothiocyanate 55
                                      allyl isothiocyanate 55
paths to the root