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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:allyl isothiocyanate
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Accession:CHEBI:73224 term browser browse the term
Definition:An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
Synonyms:related_synonym: 2-propenyl isothiocyanate;   3-Isothiocyanato-1-propene;   3-Isothiocyanatoprop-1-ene;   AIT;   AITC;   Allylsenfoel;   Formula=C4H5NS;   InChI=1S/C4H5NS/c1-2-3-5-4-6/h2H,1,3H2;   InChIKey=ZOJBYZNEUISWFT-UHFFFAOYSA-N;   Mustard oil;   SMILES=C=CCN=C=S;   Senf oel;   allyl isosulfocyanate;   allyl mustard oil;   isothiocyanate d'allyle;   isothiocyanic acid allyl ester;   oil of mustard;   oleum sinapis;   volatile mustard oil;   volatile oil of mustard
 xref: CAS:57-06-7;   HMDB:HMDB0005843;   KEGG:C19317;   KEGG:D02818
 xref_mesh: MESH:C004471
 xref: PMID:20174640;   PMID:21237300;   PMID:21711355;   PMID:22093285;   PMID:22104119;   PMID:22131350;   PMID:22265303;   PMID:23008020;   PMID:23072699;   PMID:23212023;   PMID:23470258;   PMID:23535540;   PMID:23757176;   Reaxys:773748;   Wikipedia:Allyl_isothiocyanate


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allyl isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO allyl isothiocyanate results in decreased expression of ACTA2 mRNA CTD PMID:24036144 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression ISO allyl isothiocyanate results in decreased expression of AGER mRNA CTD PMID:24036144 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of AIF1 protein] CTD PMID:27241356 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO allyl isothiocyanate results in decreased phosphorylation of AKT1 protein CTD PMID:37318315 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] CTD PMID:17571167 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases phosphorylation ISO allyl isothiocyanate results in decreased phosphorylation of BRAF protein CTD PMID:37318315 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion 		EXP safranal inhibits the reaction [allyl isothiocyanate results in increased secretion of CALCA protein] CTD PMID:30636360 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases cleavage 		ISO AG 1879 inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein] CTD PMID:23219522 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:25744308 PMID:27241356 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO allyl isothiocyanate results in increased expression of CDKN1A mRNA CTD PMID:17937621 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO allyl isothiocyanate results in decreased expression of COL1A1 mRNA CTD PMID:24036144 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]
allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA] 		CTD PMID:25069801 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
decreases activity
multiple interactions 		EXP
ISO 		allyl isothiocyanate results in decreased expression of CYP3A2 mRNA
allyl isothiocyanate results in decreased activity of CYP3A2 protein
allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]
allyl isothiocyanate results in decreased activity of CYP3A4 protein
allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [SR 12813 results in increased expression of CYP3A4 mRNA] 		CTD PMID:22664424 PMID:25069801 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO allyl isothiocyanate results in increased expression of GADD45A mRNA CTD PMID:17937621 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions
increases expression 		ISO allyl isothiocyanate results in increased activity of GCLC protein
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA] 		CTD PMID:24036144 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of GPT protein]] CTD PMID:27241356 PMID:30927557 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO allyl isothiocyanate results in decreased expression of GRB2 protein CTD PMID:37318315 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity
decreases activity
multiple interactions 		EXP
ISO 		allyl isothiocyanate results in increased activity of GSR protein
allyl isothiocyanate results in decreased activity of GSR protein
allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein] 		CTD PMID:17937621 PMID:22664424 PMID:25744308 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing ISO GSTM1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing ISO GSTP1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
multiple interactions 		EXP
ISO 		allyl isothiocyanate results in increased activity of HMOX1 protein
allyl isothiocyanate results in increased expression of HMOX1 mRNA; allyl isothiocyanate results in increased expression of HMOX1 protein
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein] 		CTD PMID:22664424 PMID:23942037 PMID:27241356 PMID:34635025 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of INS1 protein]] CTD PMID:30927557 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation 		ISO [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]
allyl isothiocyanate results in decreased phosphorylation of MAPK1 protein 		CTD PMID:23219522 PMID:23994502 PMID:37318315 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation 		ISO allyl isothiocyanate results in increased phosphorylation of MAPK3 protein
[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]
allyl isothiocyanate results in decreased phosphorylation of MAPK3 protein 		CTD PMID:23219522 PMID:23994502 PMID:37318315 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO allyl isothiocyanate results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:37318315 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO allyl isothiocyanate results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:37318315 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO allyl isothiocyanate results in increased expression of MUC5AC mRNA CTD PMID:31944254 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO allyl isothiocyanate results in increased expression of NDRG1 mRNA CTD PMID:17937621 NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
increases activity 		EXP
ISO 		allyl isothiocyanate results in increased expression of NFE2L2 protein
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to allyl isothiocyanate]
allyl isothiocyanate results in increased activity of NFE2L2 protein
allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein] 		CTD PMID:20932822 PMID:22664424 PMID:24036144 PMID:30927557 PMID:34635025 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression 		EXP allyl isothiocyanate results in increased activity of NQO1 protein
allyl isothiocyanate results in increased expression of NQO1 mRNA 		CTD PMID:22664424 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO
EXP 		allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]]
allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA] 		CTD PMID:25069801 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA]
allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]] 		CTD PMID:25069801 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO allyl isothiocyanate results in decreased expression of PDGFRB mRNA CTD PMID:24036144 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions ISO allyl isothiocyanate results in decreased expression of and results in decreased phosphorylation of PDPK1 protein CTD PMID:37318315 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO allyl isothiocyanate results in decreased expression of PLAU protein CTD PMID:37318315 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of PPARG protein] CTD PMID:30927557 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO allyl isothiocyanate results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:37318315 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO allyl isothiocyanate results in decreased expression of RHOA protein CTD PMID:37318315 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]] CTD PMID:30927557 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO allyl isothiocyanate results in decreased expression of SNAI1 protein CTD PMID:37318315 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO allyl isothiocyanate results in decreased expression of SOS1 protein CTD PMID:37318315 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP allyl isothiocyanate results in increased secretion of TAC1 protein CTD PMID:16725114 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO 		allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] 		CTD PMID:27241356 PMID:28483571 PMID:34635025 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP allyl isothiocyanate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:34635025 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
affects response to substance 		ISO
EXP 		2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; [allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium; Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]; BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased uptake of Calcium]
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [TRPA1 protein results in increased susceptibility to sodium persulfate] which affects the susceptibility to allyl isothiocyanate; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein; Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gentamicins inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Indomethacin inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]
TRPA1 mRNA affects the susceptibility to allyl isothiocyanate; TRPA1 protein polymorphism affects the susceptibility to allyl isothiocyanate
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to allyl isothiocyanate 		CTD PMID:15046718 PMID:15843607 PMID:17314320 PMID:17571167 PMID:17825279 More... NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases activity ISO allyl isothiocyanate results in increased activity of TRPM8 protein CTD PMID:29054683 NCBI chr 9:96,315,567...96,437,959
Ensembl chr 9:88,903,880...88,988,552 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases activity 		ISO TRPV1 affects the susceptibility to allyl isothiocyanate
allyl isothiocyanate results in increased activity of TRPV1 protein 		CTD PMID:21430076 PMID:29054683 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity ISO allyl isothiocyanate results in decreased activity of TXNRD1 protein CTD PMID:17937621 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vim vimentin decreases expression ISO allyl isothiocyanate results in decreased expression of VIM protein CTD PMID:37318315 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        antimicrobial agent 18575
          allyl isothiocyanate 55
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organosulfur compound 17766
                                  isothiocyanate 3547
                                    alkenyl isothiocyanate 55
                                      allyl isothiocyanate 55
paths to the root