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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:allyl isothiocyanate
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Accession:CHEBI:73224 term browser browse the term
Definition:An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
Synonyms:related_synonym: 2-propenyl isothiocyanate;   3-Isothiocyanato-1-propene;   3-Isothiocyanatoprop-1-ene;   AIT;   AITC;   Allylsenfoel;   Formula=C4H5NS;   InChI=1S/C4H5NS/c1-2-3-5-4-6/h2H,1,3H2;   InChIKey=ZOJBYZNEUISWFT-UHFFFAOYSA-N;   Mustard oil;   SMILES=C=CCN=C=S;   Senf oel;   allyl isosulfocyanate;   allyl mustard oil;   isothiocyanate d'allyle;   isothiocyanic acid allyl ester;   oil of mustard;   oleum sinapis;   volatile mustard oil;   volatile oil of mustard
 xref: CAS:57-06-7;   HMDB:HMDB0005843;   KEGG:C19317;   KEGG:D02818
 xref_mesh: MESH:C004471
 xref: PMID:20174640;   PMID:21237300;   PMID:21711355;   PMID:22093285;   PMID:22104119;   PMID:22131350;   PMID:22265303;   PMID:23008020;   PMID:23072699;   PMID:23212023;   PMID:23470258;   PMID:23535540;   PMID:23757176;   Reaxys:773748;   Wikipedia:Allyl_isothiocyanate


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allyl isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO allyl isothiocyanate results in decreased expression of ACTA2 mRNA CTD PMID:24036144 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression ISO allyl isothiocyanate results in decreased expression of AGER mRNA CTD PMID:24036144 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of AIF1 protein] CTD PMID:27241356 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] CTD PMID:17571167 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion
EXP safranal inhibits the reaction [allyl isothiocyanate results in increased secretion of CALCA protein] CTD PMID:30636360 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases cleavage
ISO AG 1879 inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein] CTD PMID:23219522 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:25744308 PMID:27241356 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO allyl isothiocyanate results in increased expression of CDKN1A mRNA CTD PMID:17937621 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO allyl isothiocyanate results in decreased expression of COL1A1 mRNA CTD PMID:24036144 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA] CTD PMID:25069801 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]] CTD PMID:25069801 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
decreases activity
EXP
ISO
allyl isothiocyanate results in decreased expression of CYP3A2 mRNA
allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]
allyl isothiocyanate results in decreased activity of CYP3A4 protein
allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]
allyl isothiocyanate results in decreased activity of CYP3A2 protein
CTD PMID:22664424 PMID:25069801 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO allyl isothiocyanate results in increased expression of GADD45A mRNA CTD PMID:17937621 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
multiple interactions
ISO allyl isothiocyanate results in increased activity of GCLC protein
allyl isothiocyanate results in increased expression of GCLC mRNA
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]
CTD PMID:24036144 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of GPT protein]] CTD PMID:27241356 PMID:30927557 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase increases activity
multiple interactions
decreases activity
EXP
ISO
allyl isothiocyanate results in increased activity of GSR protein
allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein]
allyl isothiocyanate results in decreased activity of GSR protein
CTD PMID:17937621 PMID:22664424 PMID:25744308 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases activity ISO allyl isothiocyanate results in increased activity of GSTA3 promoter CTD PMID:19232536 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing ISO GSTM1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing ISO GSTP1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression
EXP
ISO
allyl isothiocyanate results in increased activity of HMOX1 protein
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]
allyl isothiocyanate results in increased expression of HMOX1 protein
allyl isothiocyanate results in increased expression of HMOX1 mRNA; allyl isothiocyanate results in increased expression of HMOX1 protein
CTD PMID:22664424 PMID:23942037 PMID:27241356 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein] CTD PMID:23219522 PMID:23994502 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO allyl isothiocyanate results in increased phosphorylation of MAPK3 protein
[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]
CTD PMID:23219522 PMID:23994502 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO allyl isothiocyanate results in increased expression of MUC5AC mRNA CTD PMID:31944254 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO allyl isothiocyanate results in increased expression of NDRG1 mRNA CTD PMID:17937621 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
increases activity
EXP
ISO
allyl isothiocyanate results in increased expression of NFE2L2 protein
allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]
allyl isothiocyanate results in increased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to allyl isothiocyanate]
CTD PMID:20932822 PMID:22664424 PMID:24036144 PMID:30927557 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
EXP allyl isothiocyanate results in increased activity of NQO1 protein
allyl isothiocyanate results in increased expression of NQO1 mRNA
CTD PMID:22664424 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO
EXP
allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]]
allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]
CTD PMID:25069801 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA]
allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]
CTD PMID:25069801 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO allyl isothiocyanate results in decreased expression of PDGFRB mRNA CTD PMID:24036144 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of PPARG protein] CTD PMID:30927557 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]] CTD PMID:30927557 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP allyl isothiocyanate results in increased secretion of TAC1 protein CTD PMID:16725114 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]
allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:27241356 PMID:28483571 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
affects response to substance
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; [allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium; Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]; BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased uptake of Calcium]
TRPA1 affects the susceptibility to allyl isothiocyanate
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein
TRPA1 mRNA affects the susceptibility to allyl isothiocyanate; TRPA1 protein polymorphism affects the susceptibility to allyl isothiocyanate
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [TRPA1 protein results in increased susceptibility to sodium persulfate] which affects the susceptibility to allyl isothiocyanate; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein; Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gentamicins inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Indomethacin inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]
CTD PMID:15046718 PMID:15843607 PMID:17314320 PMID:17571167 PMID:17825279 More... NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases activity ISO allyl isothiocyanate results in increased activity of TRPM8 protein CTD PMID:29054683 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases activity
ISO TRPV1 affects the susceptibility to allyl isothiocyanate
allyl isothiocyanate results in increased activity of TRPV1 protein
CTD PMID:21430076 PMID:29054683 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity ISO allyl isothiocyanate results in decreased activity of TXNRD1 protein CTD PMID:17937621 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          allyl isothiocyanate 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organosulfur compound 15272
                                  isothiocyanate 3463
                                    allyl isothiocyanate 43
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