|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of ACTA2 mRNA
|
CTD |
PMID:24036144 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
|
|
G
|
Ager
|
advanced glycosylation end product-specific receptor
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of AGER mRNA
|
CTD |
PMID:24036144 |
|
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078
|
|
G
|
Aif1
|
allograft inflammatory factor 1
|
multiple interactions
|
EXP
|
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of AIF1 protein]
|
CTD |
PMID:27241356 |
|
NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
decreases phosphorylation
|
ISO
|
allyl isothiocyanate results in decreased phosphorylation of AKT1 protein
|
CTD |
PMID:37318315 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Bdkrb2
|
bradykinin receptor B2
|
multiple interactions
|
ISO
|
BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]
|
CTD |
PMID:17571167 |
|
NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497
|
|
G
|
Braf
|
B-Raf proto-oncogene, serine/threonine kinase
|
decreases phosphorylation
|
ISO
|
allyl isothiocyanate results in decreased phosphorylation of BRAF protein
|
CTD |
PMID:37318315 |
|
NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
|
|
G
|
Calca
|
calcitonin-related polypeptide alpha
|
multiple interactions increases secretion
|
EXP
|
safranal inhibits the reaction [allyl isothiocyanate results in increased secretion of CALCA protein]
|
CTD |
PMID:30636360 |
|
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions decreases cleavage
|
ISO
|
AG 1879 inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]
|
CTD |
PMID:23219522 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
EXP
|
allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
|
CTD |
PMID:25744308 PMID:27241356 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression
|
ISO
|
allyl isothiocyanate results in increased expression of CDKN1A mRNA
|
CTD |
PMID:17937621 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of COL1A1 mRNA
|
CTD |
PMID:24036144 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
|
|
G
|
Cyp2b3
|
cytochrome P450, family 2, subfamily b, polypeptide 3
|
multiple interactions
|
ISO
|
allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]] allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA]
|
CTD |
PMID:25069801 |
|
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
decreases expression decreases activity multiple interactions
|
EXP ISO
|
allyl isothiocyanate results in decreased expression of CYP3A2 mRNA allyl isothiocyanate results in decreased activity of CYP3A2 protein allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA] allyl isothiocyanate results in decreased activity of CYP3A4 protein allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]
|
CTD |
PMID:22664424 PMID:25069801 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
|
|
G
|
F2rl1
|
F2R like trypsin receptor 1
|
multiple interactions
|
ISO
|
edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]
|
CTD |
PMID:17571167 |
|
NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:26,772,278...26,785,226
|
|
G
|
Gadd45a
|
growth arrest and DNA-damage-inducible, alpha
|
increases expression
|
ISO
|
allyl isothiocyanate results in increased expression of GADD45A mRNA
|
CTD |
PMID:17937621 |
|
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
increases activity multiple interactions increases expression
|
ISO
|
allyl isothiocyanate results in increased activity of GCLC protein NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]
|
CTD |
PMID:24036144 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
EXP
|
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of GPT protein]]
|
CTD |
PMID:27241356 PMID:30927557 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Grb2
|
growth factor receptor bound protein 2
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of GRB2 protein
|
CTD |
PMID:37318315 |
|
NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
increases activity decreases activity multiple interactions
|
EXP ISO
|
allyl isothiocyanate results in increased activity of GSR protein allyl isothiocyanate results in decreased activity of GSR protein allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein]
|
CTD |
PMID:17937621 PMID:22664424 PMID:25744308 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
|
|
G
|
Gstm1
|
glutathione S-transferase mu 1
|
affects metabolic processing
|
ISO
|
GSTM1 protein affects the metabolism of allyl isothiocyanate
|
CTD |
PMID:7826396 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
|
|
G
|
Gstp1
|
glutathione S-transferase pi 1
|
affects metabolic processing
|
ISO
|
GSTP1 protein affects the metabolism of allyl isothiocyanate
|
CTD |
PMID:7826396 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
|
|
G
|
Hmox1
|
heme oxygenase 1
|
increases activity increases expression multiple interactions
|
EXP ISO
|
allyl isothiocyanate results in increased activity of HMOX1 protein allyl isothiocyanate results in increased expression of HMOX1 mRNA; allyl isothiocyanate results in increased expression of HMOX1 protein allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
|
CTD |
PMID:22664424 PMID:23942037 PMID:27241356 PMID:34635025 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Hnf4a
|
hepatocyte nuclear factor 4, alpha
|
multiple interactions
|
ISO
|
allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]
|
CTD |
PMID:25069801 |
|
NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
EXP
|
allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of INS1 protein]]
|
CTD |
PMID:30927557 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions increases phosphorylation decreases phosphorylation
|
ISO
|
[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein] allyl isothiocyanate results in decreased phosphorylation of MAPK1 protein
|
CTD |
PMID:23219522 PMID:23994502 PMID:37318315 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
increases phosphorylation multiple interactions decreases phosphorylation
|
ISO
|
allyl isothiocyanate results in increased phosphorylation of MAPK3 protein [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein] allyl isothiocyanate results in decreased phosphorylation of MAPK3 protein
|
CTD |
PMID:23219522 PMID:23994502 PMID:37318315 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
ISO
|
allyl isothiocyanate results in decreased expression of and results in decreased activity of MMP2 protein
|
CTD |
PMID:37318315 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions
|
ISO
|
allyl isothiocyanate results in decreased expression of and results in decreased activity of MMP9 protein
|
CTD |
PMID:37318315 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
|
|
G
|
Muc5ac
|
mucin 5AC, oligomeric mucus/gel-forming
|
increases expression
|
ISO
|
allyl isothiocyanate results in increased expression of MUC5AC mRNA
|
CTD |
PMID:31944254 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
|
|
G
|
Ndrg1
|
N-myc downstream regulated 1
|
increases expression
|
ISO
|
allyl isothiocyanate results in increased expression of NDRG1 mRNA
|
CTD |
PMID:17937621 |
|
NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
increases expression multiple interactions increases activity
|
EXP ISO
|
allyl isothiocyanate results in increased expression of NFE2L2 protein NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to allyl isothiocyanate] allyl isothiocyanate results in increased activity of NFE2L2 protein allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]
|
CTD |
PMID:20932822 PMID:22664424 PMID:24036144 PMID:30927557 PMID:34635025 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
increases activity increases expression
|
EXP
|
allyl isothiocyanate results in increased activity of NQO1 protein allyl isothiocyanate results in increased expression of NQO1 mRNA
|
CTD |
PMID:22664424 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
multiple interactions
|
ISO EXP
|
allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]] allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]
|
CTD |
PMID:25069801 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
|
|
G
|
Nr1i3
|
nuclear receptor subfamily 1, group I, member 3
|
multiple interactions
|
ISO
|
allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA] allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]
|
CTD |
PMID:25069801 |
|
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
|
|
G
|
Pdgfrb
|
platelet derived growth factor receptor beta
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of PDGFRB mRNA
|
CTD |
PMID:24036144 |
|
NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
|
|
G
|
Pdpk1
|
3-phosphoinositide dependent protein kinase-1
|
multiple interactions
|
ISO
|
allyl isothiocyanate results in decreased expression of and results in decreased phosphorylation of PDPK1 protein
|
CTD |
PMID:37318315 |
|
NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623
|
|
G
|
Plau
|
plasminogen activator, urokinase
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of PLAU protein
|
CTD |
PMID:37318315 |
|
NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
EXP
|
allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of PPARG protein]
|
CTD |
PMID:30927557 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
multiple interactions
|
ISO
|
allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]
|
CTD |
PMID:25069801 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
|
|
G
|
Pten
|
phosphatase and tensin homolog
|
multiple interactions
|
ISO
|
allyl isothiocyanate results in increased expression of and results in increased phosphorylation of PTEN protein
|
CTD |
PMID:37318315 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
|
|
G
|
Rhoa
|
ras homolog family member A
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of RHOA protein
|
CTD |
PMID:37318315 |
|
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
|
|
G
|
Rxra
|
retinoid X receptor alpha
|
multiple interactions
|
ISO
|
allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]
|
CTD |
PMID:25069801 |
|
NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712
|
|
G
|
Slc2a2
|
solute carrier family 2 member 2
|
multiple interactions
|
EXP
|
allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]]
|
CTD |
PMID:30927557 |
|
NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933
|
|
G
|
Snai1
|
snail family transcriptional repressor 1
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of SNAI1 protein
|
CTD |
PMID:37318315 |
|
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
|
|
G
|
Sos1
|
SOS Ras/Rac guanine nucleotide exchange factor 1
|
decreases expression
|
ISO
|
allyl isothiocyanate results in decreased expression of SOS1 protein
|
CTD |
PMID:37318315 |
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NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107
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G
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Src
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SRC proto-oncogene, non-receptor tyrosine kinase
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multiple interactions
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ISO
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allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]
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CTD |
PMID:25069801 |
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NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
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G
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Tac1
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tachykinin, precursor 1
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increases secretion
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EXP
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allyl isothiocyanate results in increased secretion of TAC1 protein
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CTD |
PMID:16725114 |
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NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178
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G
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Tnf
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tumor necrosis factor
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multiple interactions
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EXP ISO
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allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; allyl isothiocyanate inhibits the reaction [Doxorubicin results in increased expression of TNF protein] allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
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CTD |
PMID:27241356 PMID:28483571 PMID:34635025 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G
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Tnni3
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troponin I3, cardiac type
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multiple interactions
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EXP
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allyl isothiocyanate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein]
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CTD |
PMID:34635025 |
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G
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Trpa1
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transient receptor potential cation channel, subfamily A, member 1
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multiple interactions increases activity affects response to substance
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ISO EXP
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2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; [allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium; Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]; BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased uptake of Calcium] 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [TRPA1 protein results in increased susceptibility to sodium persulfate] which affects the susceptibility to allyl isothiocyanate; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein; Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gentamicins inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Indomethacin inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] TRPA1 mRNA affects the susceptibility to allyl isothiocyanate; TRPA1 protein polymorphism affects the susceptibility to allyl isothiocyanate 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein TRPA1 affects the susceptibility to allyl isothiocyanate
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CTD |
PMID:15046718 PMID:15843607 PMID:17314320 PMID:17571167 PMID:17825279 PMID:19507004 PMID:20086034 PMID:20442136 PMID:20720158 PMID:21689654 PMID:22935519 PMID:23994502 PMID:26039217 PMID:27735854 PMID:27738742 PMID:29054683 PMID:30636360 PMID:30738091 PMID:36693442 More...
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NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570
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G
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Trpm8
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transient receptor potential cation channel, subfamily M, member 8
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increases activity
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ISO
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allyl isothiocyanate results in increased activity of TRPM8 protein
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CTD |
PMID:29054683 |
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NCBI chr 9:96,315,567...96,437,959
Ensembl chr 9:88,903,880...88,988,552
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G
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Trpv1
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transient receptor potential cation channel, subfamily V, member 1
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affects response to substance increases activity
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ISO
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TRPV1 affects the susceptibility to allyl isothiocyanate allyl isothiocyanate results in increased activity of TRPV1 protein
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CTD |
PMID:21430076 PMID:29054683 |
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NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
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G
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Txnrd1
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thioredoxin reductase 1
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decreases activity
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ISO
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allyl isothiocyanate results in decreased activity of TXNRD1 protein
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CTD |
PMID:17937621 |
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NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863
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G
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Vcam1
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vascular cell adhesion molecule 1
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multiple interactions
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ISO
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allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
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CTD |
PMID:28483571 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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G
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Vim
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vimentin
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decreases expression
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ISO
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allyl isothiocyanate results in decreased expression of VIM protein
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CTD |
PMID:37318315 |
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NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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