antimutagen - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	antimutagen	go back to main search page
Accession:	CHEBI:73190	browse the term
Definition:	An agent that reduces or interferes with the mutagenic actions or effects of a substance.
Synonyms:	related_synonym:	antimutagenic agent; antimutagenic agents; antimutagens

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Rat (92) Mouse (98) Human (91) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (92)

anthraflavic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

affects binding

2,6-dihydroxyanthraquinone binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

PMID:12756209 PMID:14557274

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

dibenzoylmethane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

increases expression

dibenzoylmethane results in increased expression of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

dibenzoylmethane results in decreased phosphorylation of AKT1 protein
[dibenzoylmethane co-treated with sulforaphane] results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2-associated agonist of cell death

multiple interactions
increases expression

ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

increases expression

dibenzoylmethane results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 9

multiple interactions

ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

carbonyl reductase 3

increases expression
multiple interactions

dibenzoylmethane results in increased expression of CBR3 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of CBR3 mRNA

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

cyclin D1

decreases expression

dibenzoylmethane results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

decreases expression

dibenzoylmethane results in decreased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

clusterin

decreases expression
multiple interactions

dibenzoylmethane results in decreased expression of CLU mRNA
[sulforaphane co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

epoxide hydrolase 1

increases activity
multiple interactions
increases expression

dibenzoylmethane results in increased activity of EPHX1 protein
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA
dibenzoylmethane results in increased expression of EPHX1 mRNA

PMID:3621371 PMID:17942926

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

estrogen receptor 1

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

dibenzoylmethane results in increased expression of GCLC mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutathione S-transferase mu 1

increases expression
multiple interactions

dibenzoylmethane results in increased expression of GSTM1 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase, mu 5

multiple interactions
increases expression

[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA
dibenzoylmethane results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

HRas proto-oncogene, GTPase

multiple interactions

dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

ornithine decarboxylase 1

multiple interactions
decreases response to substance

ODC1 protein inhibits the reaction [dibenzoylmethane results in increased abundance of Reactive Oxygen Species]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]
ODC1 protein results in decreased susceptibility to dibenzoylmethane

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

prostaglandin reductase 1

multiple interactions

[sulforaphane co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin-endoperoxide synthase 2

decreases expression

dibenzoylmethane results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

telomerase reverse transcriptase

multiple interactions

dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA]

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

oltipraz

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

oltipraz results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression

oltipraz results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

multiple interactions

[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression

[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA
oltipraz results in increased expression of ABCC2 mRNA; oltipraz results in increased expression of ABCC2 protein

PMID:12920174 PMID:15833929 PMID:16837569 PMID:18032408 PMID:25752797 More...

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions

oltipraz results in increased expression of ABCC3 mRNA
oltipraz results in increased expression of ABCC3 mRNA; oltipraz results in increased expression of ABCC3 protein
[oltipraz results in increased expression of ABCC3 protein] which affects the export of Acetaminophen metabolite
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of ABCC3 mRNA]

PMID:12920174 PMID:15833929 PMID:16837569 PMID:22496397 PMID:30114225

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

multiple interactions
increases expression

[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]
oltipraz promotes the reaction [ABCC4 protein results in increased transport of Arsenic]
oltipraz results in increased expression of ABCC4 mRNA; oltipraz results in increased expression of ABCC4 protein

PMID:15833929 PMID:18032408 PMID:20395535 PMID:22496397 PMID:25752797

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

multiple interactions
increases expression

[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC5 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA
oltipraz results in increased expression of ABCC5 mRNA

PMID:15833929 PMID:18032408

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily C member 6

multiple interactions
increases expression

[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA
oltipraz results in increased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily G member 2

multiple interactions
increases activity
increases expression

oltipraz promotes the reaction [ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite]
oltipraz results in increased activity of ABCG2 protein
oltipraz results in increased expression of ABCG2 mRNA

PMID:15917307 PMID:16837569

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

multiple interactions

[oltipraz co-treated with NFE2L2 protein mutant form] affects the expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

angiotensin I converting enzyme

multiple interactions

oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of ACE mRNA]]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

multiple interactions

oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in decreased expression of ACE2 mRNA]]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]]

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

angiotensinogen

multiple interactions

oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of AGT mRNA]]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions
increases activity

[oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA; oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]; resveratrol inhibits the reaction [[oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA]
oltipraz results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 7 member A3

increases activity

oltipraz results in increased activity of AKR7A3 protein

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

albumin

decreases expression

oltipraz results in decreased expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions
increases expression

[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ALDH1A1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ALDH1A1 mRNA]

PMID:17998271 PMID:22496397

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Lithocholic Acid co-treated with oltipraz] results in increased expression of BAX mRNA
oltipraz inhibits the reaction [Acetaminophen results in increased expression of BAX protein]

PMID:19433268 PMID:33959992

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

multiple interactions

[Lithocholic Acid co-treated with oltipraz] results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

caspase 3

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

CCAAT/enhancer binding protein beta

multiple interactions

[Dexamethasone co-treated with oltipraz] results in increased activity of CEBPB protein; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein]; oltipraz promotes the reaction [CEBPB protein binds to GSTA2 promoter]; oltipraz results in increased localization of and results in increased activity of CEBPB protein

PMID:12509401 PMID:15319326 PMID:15870285

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

carboxylesterase 1D

increases expression
multiple interactions

oltipraz results in increased expression of CES1 mRNA
NFE2L2 protein promotes the reaction [oltipraz results in increased expression of CES1 mRNA]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2C

increases expression
multiple interactions

oltipraz results in increased expression of CES2C mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES2C mRNA]

NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
affects activity
decreases activity
increases expression
affects metabolic processing

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [oltipraz results in increased expression of CYP1A1 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [[oltipraz results in increased abundance of Calcium] which results in increased expression of CYP1A1 mRNA]; [oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA; [oltipraz results in increased abundance of Calcium] which results in increased expression of CYP1A1 mRNA; oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]; oltipraz results in increased expression of and results in increased activity of CYP1A1 protein; resveratrol inhibits the reaction [[oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [oltipraz results in increased expression of CYP1A1 mRNA]
oltipraz affects the activity of CYP1A1 protein
oltipraz metabolite results in decreased activity of CYP1A1 protein
oltipraz results in increased expression of CYP1A1 mRNA; oltipraz results in increased expression of CYP1A1 protein
CYP1A1 protein affects the metabolism of oltipraz

PMID:10775323 PMID:11959854 PMID:15831204 PMID:15890477 PMID:15920769

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
affects metabolic processing
multiple interactions
increases activity
increases expression

oltipraz metabolite results in decreased activity of CYP1A2 protein; oltipraz results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of oltipraz
oltipraz inhibits the reaction [CYP1A2 results in increased activity of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline]
oltipraz results in increased activity of CYP1A2 protein
oltipraz results in increased expression of CYP1A2 mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of CYP1A2 mRNA]

PMID:8625305 PMID:10775323 PMID:15831204 PMID:15920769 PMID:22496397

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity
increases expression
affects activity

oltipraz metabolite results in decreased activity of CYP1B1 protein
oltipraz results in increased expression of CYP1B1 mRNA
oltipraz affects the activity of CYP1B1 protein

PMID:10775323 PMID:15890477

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 1

affects metabolic processing

CYP2B1 protein affects the metabolism of oltipraz

PMID:15831204 PMID:15920769

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects metabolic processing

CYP2B2 protein affects the metabolism of oltipraz

PMID:15831204 PMID:15920769

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity
increases expression

oltipraz results in decreased activity of CYP2B6 protein
oltipraz results in increased expression of CYP2B6 mRNA; oltipraz results in increased expression of CYP2B6 protein
oltipraz results in increased expression of CYP2B10 mRNA

PMID:17627975 PMID:19833192

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

affects metabolic processing

CYP2C11 protein affects the metabolism of oltipraz

PMID:15831204 PMID:15920769

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily d, polypeptide 1

affects metabolic processing

CYP2D1 protein affects the metabolism of oltipraz

PMID:15831204 PMID:15920769

NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects activity

oltipraz affects the activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
affects activity
decreases activity

CYP3A2 protein affects the metabolism of oltipraz
oltipraz affects the activity of CYP3A4 protein
oltipraz metabolite results in decreased activity of CYP3A4 protein; oltipraz results in decreased activity of CYP3A4 protein

PMID:10775323 PMID:15831204 PMID:15920769 PMID:19833192

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects metabolic processing

CYP3A23-3A1 protein affects the metabolism of oltipraz

PMID:15831204 PMID:15920769

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

glutamic-oxaloacetic transaminase 1

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 3

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in decreased activity of GPX3 protein]

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione S-transferase alpha 1

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in decreased expression of and results in increased secretion of GSTA1 protein]; oltipraz inhibits the reaction [Acetaminophen results in decreased expression of GSTA1 mRNA]; oltipraz inhibits the reaction [Acetaminophen results in decreased expression of GSTA1 protein]

PMID:31385618 PMID:33959992

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

increases expression
multiple interactions

oltipraz results in increased expression of GSTA2 mRNA; oltipraz results in increased expression of GSTA2 protein
2-tert-butylhydroquinone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; oltipraz promotes the reaction [CEBPB protein binds to GSTA2 promoter]

PMID:9203627 PMID:12242683 PMID:12509401 PMID:15155840 PMID:15319326 More...

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

increases expression

oltipraz results in increased expression of GSTA3 mRNA; oltipraz results in increased expression of GSTA3 protein

PMID:9203627 PMID:9794803

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 5

increases activity
increases expression

oltipraz results in increased activity of GSTA5 protein
oltipraz results in increased expression of GSTA5 mRNA; oltipraz results in increased expression of GSTA5 protein

PMID:8051171 PMID:8625305 PMID:9203627 PMID:9328168

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

multiple interactions
increases expression

[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM1 mRNA]

PMID:9203627 PMID:18723825 PMID:22496397

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

multiple interactions
increases expression

[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM2 mRNA]

PMID:18723825 PMID:22496397

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase mu 4

multiple interactions
increases expression

[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM4 mRNA]

PMID:18723825 PMID:22496397

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5

multiple interactions
increases expression

[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM3 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM3 mRNA]
oltipraz results in increased expression of GSTM3 protein

PMID:9794803 PMID:18723825 PMID:22496397

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

increases expression
multiple interactions

oltipraz results in increased expression of GSTP1 mRNA
oltipraz results in increased expression of and results in increased activity of GSTP1 protein
oltipraz results in increased expression of GSTP1 protein

PMID:9794803 PMID:15374950 PMID:16950796

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

affects localization
increases expression

oltipraz affects the localization of GSTT1 protein
oltipraz results in increased expression of GSTT1 protein

PMID:9794803 PMID:9855024 PMID:10413528

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

HNF1 homeobox A

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in decreased expression of HNF1A mRNA]; oltipraz inhibits the reaction [Acetaminophen results in decreased expression of HNF1A protein]

PMID:31385618 PMID:33959992

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

insulin 2

multiple interactions

oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]]; oltipraz inhibits the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

involucrin

decreases expression

oltipraz results in decreased expression of IVL protein

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

mitogen-activated protein kinase 8

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MAS1 proto-oncogene, G protein-coupled receptor

multiple interactions

oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in decreased expression of MAS1 mRNA]]

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

[Lithocholic Acid co-treated with oltipraz] results in increased expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

O-6-methylguanine-DNA methyltransferase

increases expression
multiple interactions

oltipraz results in increased expression of MGMT mRNA
oltipraz results in increased expression of and results in increased activity of MGMT protein

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microsomal glutathione S-transferase 3

multiple interactions
increases expression

[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of MGST3 mRNA
oltipraz results in increased expression of MGST3 mRNA

PMID:18723825 PMID:22496397

NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411

G

NFE2 like bZIP transcription factor 2

affects activity
affects response to substance
multiple interactions
increases activity

oltipraz affects the activity of NFE2L2 protein
NFE2L2 protein affects the susceptibility to oltipraz
[oltipraz co-treated with NFE2L2 protein mutant form] affects the expression of ABCG5 mRNA; [oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B1 mRNA; [oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B35 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ALDH1A1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of MGST3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ALDH1A1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES1G mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES2C mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CYP1A2 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM2 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM3 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of SULT3A1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT1A6A mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B34 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B36 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of CES1 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of NQO1 mRNA]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]]; oltipraz binds to and results in increased activity of NFE2L2 protein; oltipraz inhibits the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of NFE2L2 protein]]

PMID:11309284 PMID:15833929 PMID:15919853 PMID:19150646 PMID:20086057 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases activity
multiple interactions
increases expression

oltipraz results in increased activity of NQO1 protein
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of NQO1 mRNA]; oltipraz promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA]
oltipraz metabolite results in increased expression of NQO1 protein; oltipraz results in increased expression of NQO1 mRNA; oltipraz results in increased expression of NQO1 protein
oltipraz promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]

PMID:11309284 PMID:12407167 PMID:15919853 PMID:17627975 PMID:18488193 More...

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

oltipraz inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

solute carrier family 10 member 1

decreases expression

oltipraz results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 22 member 7

decreases expression

oltipraz results in decreased expression of SLC22A7 mRNA

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier organic anion transporter family member 1B2

decreases expression

oltipraz results in decreased expression of SLCO1B3 mRNA

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2b1

increases expression

oltipraz results in increased expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

superoxide dismutase 1

multiple interactions

oltipraz inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression

oltipraz results in increased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

thioredoxin reductase 1

increases expression

oltipraz results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

uncoupling protein 2

multiple interactions

oltipraz inhibits the reaction [Doxorubicin results in decreased expression of UCP2 protein]

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

UDP glucuronosyltransferase family 1 member A1

increases expression

oltipraz results in increased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A5

increases expression

oltipraz results in increased expression of UGT1A5 mRNA

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions
increases expression

oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A6 mRNA]
oltipraz results in increased expression of UGT1A6 mRNA

PMID:15374950 PMID:19144771

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

multiple interactions

oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A7 mRNA]

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member A3

decreases expression

oltipraz results in decreased expression of UGT2A3 mRNA

NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases expression
multiple interactions

oltipraz results in decreased expression of UGT2B1 mRNA
[oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B1 mRNA

PMID:19144771 PMID:22496397

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

increases expression
multiple interactions

oltipraz results in increased expression of UGT2B34 mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B34 mRNA]

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

ortho-vanillin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of 2-vanillin

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
biological role	19785
antimutagen	92
4',5,6,7-tetramethoxyflavone	0
4',6,7-trihydroxyisoflavone	0
anthraflavic acid	6
dibenzoylmethane +	21
garbanzol	0
oltipraz	73
ortho-vanillin	1
pinobanksin	0
zinolol	0

paths to the root