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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acifluorfen
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Accession:CHEBI:73172 term browser browse the term
Definition:A member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds.
Synonyms:exact_synonym: 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid
 related_synonym: 2-nitro-5-(2-chloro-4-(trifluoromethyl)phenoxy)benzoic acid;   5-(2-Chloro-alpha,alpha,alpha-trifluoro-p-tolyloxy)-2-nitrobenzoic acid;   Blazer;   Formula=C14H7ClF3NO5;   InChI=1S/C14H7ClF3NO5/c15-10-5-7(14(16,17)18)1-4-12(10)24-8-2-3-11(19(22)23)9(6-8)13(20)21/h1-6H,(H,20,21);   InChIKey=NUFNQYOELLVIPL-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1[N+]([O-])=O;   acifluorfene
 xref: CAS:50594-66-6;   HMDB:HMDB0037112;   KEGG:C22041
 xref_mesh: MESH:C018425
 xref: MetaCyc:ACIFLUORFEN;   PDBeChem:ACJ;   PMID:11455817;   PMID:11600024;   PMID:11837431;   PMID:2211482;   PMID:2813868;   PMID:7697001;   PMID:8089433;   PMID:8761738;   PPDB:819;   Patent:EP0706993;   Reaxys:2953865;   Wikipedia:Acifluorfen


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acifluorfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to acifluorfen CTD PMID:15475374 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity ISO acifluorfen results in increased activity of CYP2A5 protein CTD PMID:9007836 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO acifluorfen results in increased expression of CYP2B10 mRNA
NR1I3 gene mutant form inhibits the reaction [acifluorfen results in increased expression of CYP2B10 mRNA]
CTD PMID:26928356 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases response to substance
ISO NR1I3 gene mutant form inhibits the reaction [acifluorfen results in increased expression of CYP2B10 mRNA]
NR1I3 gene mutant form results in decreased susceptibility to acifluorfen
CTD PMID:26928356 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO acifluorfen results in increased expression of PARP1 protein modified form CTD PMID:25944804 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppox protoporphyrinogen oxidase decreases activity ISO acifluorfen results in decreased activity of PPOX protein CTD PMID:7697001 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        agrochemical 15037
          acifluorfen 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        aromatic carboxylic acid 11710
                                          benzoic acids 11683
                                            acifluorfen 6
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