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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acifluorfen
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Accession:CHEBI:73172 term browser browse the term
Definition:A member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds.
Synonyms:exact_synonym: 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid
 related_synonym: 2-nitro-5-(2-chloro-4-(trifluoromethyl)phenoxy)benzoic acid;   5-(2-Chloro-alpha,alpha,alpha-trifluoro-p-tolyloxy)-2-nitrobenzoic acid;   Blazer;   Formula=C14H7ClF3NO5;   InChI=1S/C14H7ClF3NO5/c15-10-5-7(14(16,17)18)1-4-12(10)24-8-2-3-11(19(22)23)9(6-8)13(20)21/h1-6H,(H,20,21);   InChIKey=NUFNQYOELLVIPL-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1[N+]([O-])=O;   acifluorfene
 xref: CAS:50594-66-6;   HMDB:HMDB0037112;   KEGG:C22041
 xref_mesh: MESH:C018425
 xref: MetaCyc:ACIFLUORFEN;   PDBeChem:ACJ;   PMID:11455817;   PMID:11600024;   PMID:11837431;   PMID:2211482;   PMID:2813868;   PMID:7697001;   PMID:8089433;   PMID:8761738;   PPDB:819;   Patent:EP0706993;   Reaxys:2953865;   Wikipedia:Acifluorfen


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acifluorfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to acifluorfen CTD PMID:15475374 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity ISO acifluorfen results in increased activity of CYP2A5 protein CTD PMID:9007836 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions		 ISO acifluorfen results in increased expression of CYP2B10 mRNA
NR1I3 gene mutant form inhibits the reaction [acifluorfen results in increased expression of CYP2B10 mRNA]		 CTD PMID:26928356 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases response to substance		 ISO NR1I3 gene mutant form inhibits the reaction [acifluorfen results in increased expression of CYP2B10 mRNA]
NR1I3 gene mutant form results in decreased susceptibility to acifluorfen		 CTD PMID:26928356 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO acifluorfen results in increased expression of PARP1 protein modified form CTD PMID:25944804 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppox protoporphyrinogen oxidase decreases activity ISO acifluorfen results in decreased activity of PPOX protein CTD PMID:7697001 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        agrochemical 15206
          acifluorfen 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        aromatic carboxylic acid 11796
                                          benzoic acids 11771
                                            acifluorfen 6
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