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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acifluorfen
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Accession:CHEBI:73172 term browser browse the term
Definition:A member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds.
Synonyms:exact_synonym: 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid
 related_synonym: 2-nitro-5-(2-chloro-4-(trifluoromethyl)phenoxy)benzoic acid;   5-(2-Chloro-alpha,alpha,alpha-trifluoro-p-tolyloxy)-2-nitrobenzoic acid;   Blazer;   Formula=C14H7ClF3NO5;   InChI=1S/C14H7ClF3NO5/c15-10-5-7(14(16,17)18)1-4-12(10)24-8-2-3-11(19(22)23)9(6-8)13(20)21/h1-6H,(H,20,21);   InChIKey=NUFNQYOELLVIPL-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1[N+]([O-])=O;   acifluorfene
 xref: CAS:50594-66-6;   HMDB:HMDB0037112;   KEGG:C22041
 xref_mesh: MESH:C018425
 xref: MetaCyc:ACIFLUORFEN;   PDBeChem:ACJ;   PMID:11455817;   PMID:11600024;   PMID:11837431;   PMID:2211482;   PMID:2813868;   PMID:7697001;   PMID:8089433;   PMID:8761738;   PPDB:819;   Patent:EP0706993;   Reaxys:2953865;   Wikipedia:Acifluorfen

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acifluorfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to acifluorfen CTD PMID:15475374 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity ISO acifluorfen results in increased activity of CYP2A5 protein CTD PMID:9007836 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions		 ISO acifluorfen results in increased expression of CYP2B10 mRNA
NR1I3 gene mutant form inhibits the reaction [acifluorfen results in increased expression of CYP2B10 mRNA]		 CTD PMID:26928356 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases response to substance		 ISO NR1I3 gene mutant form inhibits the reaction [acifluorfen results in increased expression of CYP2B10 mRNA]
NR1I3 gene mutant form results in decreased susceptibility to acifluorfen		 CTD PMID:26928356 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO acifluorfen results in increased expression of PARP1 protein modified form CTD PMID:25944804 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Ppox protoporphyrinogen oxidase decreases activity ISO acifluorfen results in decreased activity of PPOX protein CTD PMID:7697001 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      application 19412
        agrochemical 14699
          acifluorfen 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic acid 18202
                                        aromatic carboxylic acid 11305
                                          benzoic acids 11276
                                            acifluorfen 6
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