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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sirtinol
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Accession:CHEBI:73158 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine.
Synonyms:exact_synonym: 2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide
 related_synonym: Formula=C26H22N2O2;   InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30);   InChIKey=UXJFDYIHRJGPFS-UHFFFAOYSA-N;   SMILES=[H]C(=Nc1ccccc1C(=O)NC(C)c1ccccc1)c1c(O)ccc2ccccc12
 xref_mesh: MESH:C439060
 xref: PMID:20595232;   PMID:22155142;   PMID:22322739;   PMID:22495798;   PMID:22669716;   PMID:22751989;   PMID:22980088;   PMID:23416120;   PMID:23422569;   PMID:23474493;   PMID:23511141;   PMID:23562377;   Patent:US2008200489;   Patent:US2009137681;   Reaxys:15029840



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sirtinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO sirtinol inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein] CTD PMID:23465592 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]] CTD PMID:26450947 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sirtinol promotes the reaction [cudraflavone B results in increased expression of BAX protein]
CTD PMID:23881456 PMID:25665036 PMID:26450947 PMID:28851138 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; sirtinol promotes the reaction [cudraflavone B results in decreased expression of BCL2 protein] CTD PMID:23881456 PMID:28851138 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
sirtinol inhibits the reaction [Resveratrol results in increased activity of CASP3 protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]]; sirtinol promotes the reaction [cudraflavone B results in increased activity of CASP3 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; sirtinol results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:20697895 PMID:23881456 PMID:24889822 PMID:25665036 PMID:26251326 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased activity of CASP9 protein] CTD PMID:20697895 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]] CTD PMID:20531350 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO sirtinol results in increased expression of CCL20 mRNA CTD PMID:22385246 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA] CTD PMID:22717288 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO sirtinol results in increased expression of CDKN1A mRNA; sirtinol results in increased expression of CDKN1A protein
sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1A protein]
CTD PMID:22495798 PMID:23881456 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1B protein] CTD PMID:23881456 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Col10a1 collagen type X alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL10A1 protein CTD PMID:26251326 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL1A1 protein CTD PMID:26251326 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL2A1 protein CTD PMID:26251326 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression EXP sirtinol results in increased expression of CYBA mRNA CTD PMID:23422569 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of CYBB protein]] CTD PMID:28851138 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO sirtinol results in increased expression of CYP1A1 mRNA
AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA]
CTD PMID:22495798 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] CTD PMID:24254769 PMID:25665036 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA CTD PMID:22146233 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases acetylation
ISO
EXP
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]
sirtinol results in increased acetylation of FOXO1 protein
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]
CTD PMID:24889822 PMID:25665036 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gh1 growth hormone 1 multiple interactions
increases secretion
increases expression
EXP sirtinol inhibits the reaction [resveratrol results in decreased secretion of GH1 protein]
sirtinol results in increased secretion of GH1 protein
sirtinol results in increased expression of GH1 mRNA
CTD PMID:23292070 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO sirtinol results in decreased expression of IGF1R mRNA CTD PMID:22495798 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO sirtinol results in increased expression of IGFBP3 mRNA CTD PMID:22495798 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
sirtinol results in increased expression of IL1B mRNA
CTD PMID:20531350 PMID:22385246 PMID:23973301 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Klf2 Kruppel-like factor 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of KLF2 mRNA] CTD PMID:19815564 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of MAPK1 protein CTD PMID:21745208 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of MAPK3 protein CTD PMID:21745208 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir141 microRNA 141 multiple interactions EXP sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NOS1 protein]]; sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]] CTD PMID:33204711 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in decreased expression of MYC protein] CTD PMID:24395567 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in increased expression of NFE2L2 protein] CTD PMID:24395567 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation ISO sirtinol results in increased degradation of NFKBIA protein CTD PMID:21745208 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO sirtinol results in decreased expression of NKX3-1 mRNA CTD PMID:22495798 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NOS1 protein]] CTD PMID:33204711 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression
EXP resveratrol inhibits the reaction [sirtinol results in increased expression of NOX4 mRNA] CTD PMID:23422569 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA] CTD PMID:26044878 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in decreased expression of PDK1 protein] CTD PMID:24395567 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of PDK4 protein]] CTD PMID:26450947 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of PDPK1 protein]] CTD PMID:26450947 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]
sirtinol inhibits the reaction [resveratrol results in increased expression of PPARGC1A protein]
CTD PMID:24395567 PMID:25159133 PMID:28477916 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]] CTD PMID:28477916 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:23257246 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO sirtinol promotes the reaction [cudraflavone B results in decreased phosphorylation of RB1 protein] CTD PMID:23881456 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases localization
ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]
sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]
sirtinol results in increased localization of RELA protein
CTD PMID:21745208 PMID:22717288 PMID:23257246 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases expression
ISO sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter]
sirtinol results in increased expression of SHC1 mRNA; sirtinol results in increased expression of SHC1 protein
CTD PMID:21778425 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sirt1 sirtuin 1 decreases activity
multiple interactions
ISO
EXP
sirtinol analog results in decreased activity of SIRT1 protein; sirtinol results in decreased activity of SIRT1 protein
[sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Plant Extracts; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol; [sirtinol results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide; sirtinol inhibits the reaction [[resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 mRNA]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter]
[sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]
sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [Resveratrol results in increased expression of and results in increased activity of SIRT1 protein]
CTD PMID:16302818 PMID:18681908 PMID:19288225 PMID:20370652 PMID:20531350 More... NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO sirtinol analog results in decreased activity of SIRT2 protein; sirtinol results in decreased activity of SIRT2 protein CTD PMID:16302818 PMID:24998427 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
G Smad1 SMAD family member 1 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD1 protein CTD PMID:21745208 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad5 SMAD family member 5 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD5 protein CTD PMID:21745208 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
JBrowse link
G Smad9 SMAD family member 9 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD9 protein CTD PMID:21745208 NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307
JBrowse link
G Snca synuclein alpha multiple interactions EXP sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]] CTD PMID:33204711 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein] CTD PMID:24889822 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein] CTD PMID:23465592 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
sirtinol inhibits the reaction [[resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein]
Sirtinol promotes the reactions [Lipopolysaccharide, acetate, acetaldehyde increases secretion of Tnf protein from Kupffer cells]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]; sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA]
sirtinol results in increased expression of TNF mRNA
CTD
RGD
PMID:20978007 PMID:22385246 PMID:22717288 PMID:23257246 PMID:23973301 More... RGD:9585771 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; sirtinol promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of TP53 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
CTD PMID:18298901 PMID:18681908 PMID:23881456 PMID:25665036 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRIM63 protein]] CTD PMID:25665036 PMID:26450947 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Usp7 ubiquitin specific peptidase 7 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of USP7 protein]] CTD PMID:25665036 NCBI chr10:6,880,684...6,925,033
Ensembl chr10:6,828,795...6,925,355
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [sirtinol co-treated with cobaltous chloride] results in increased cleavage of VEGFA protein; sirtinol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein] CTD PMID:22669716 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 20039
    role 19990
      application 19729
        anti-inflammatory agent 16331
          sirtinol 61
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  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic group 18932
                              organic divalent group 18916
                                organodiyl group 18916
                                  carbonyl group 18865
                                    carbonyl compound 18865
                                      carboxylic acid 18553
                                        carboacyl group 17652
                                          univalent carboacyl group 17652
                                            carbamoyl group 17487
                                              carboxamide 17487
                                                monocarboxylic acid amide 15057
                                                  arenecarboxamide 7274
                                                    benzamides 7274
                                                      sirtinol 61
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