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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aminonicotinic acid
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Accession:CHEBI:73130 term browser browse the term
Definition:An aromatic amino acid that is nicotinic acid in which one of the hydrogens attached to the pyridine ring is replaced by an amino group. A 'closed class'.
Synonyms:related_synonym: aminonicotinic acids

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6-aminonicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [6-Aminonicotinamide co-treated with spautin-1] results in increased degradation of EIF4A1 protein CTD PMID:30821613 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression		 ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of FGF2 protein] CTD PMID:12898533 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein] CTD PMID:25246272 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein] CTD PMID:25246272 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of IL1B protein] CTD PMID:12898533 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT1 protein]; 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT2 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of FGF2 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of IL1B protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of NTF3 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TGFB1 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TNF protein]
6-Aminonicotinamide results in increased expression of IL6 protein		 CTD PMID:12898533 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
decreases response to substance		 ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT1 protein]
6-Aminonicotinamide results in increased expression of MT1 protein
MT1 protein results in decreased susceptibility to 6-Aminonicotinamide		 CTD PMID:11835189 PMID:12898533 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
decreases response to substance		 ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT2 protein]
6-Aminonicotinamide results in increased expression of MT2 protein
MT2 protein results in decreased susceptibility to 6-Aminonicotinamide		 CTD PMID:11835189 PMID:12898533 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mt3 metallothionein 3 increases expression ISO 6-Aminonicotinamide results in increased expression of MT3 protein CTD PMID:10785446 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Ntf3 neurotrophin 3 increases expression
multiple interactions		 ISO 6-Aminonicotinamide results in increased expression of NTF3 protein
IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of NTF3 protein]		 CTD PMID:12898533 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein] CTD PMID:25246272 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO 6-Aminonicotinamide results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TGFB1 protein] CTD PMID:12898533 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO 6-Aminonicotinamide results in increased expression of TNF protein
IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TNF protein]		 CTD PMID:12898533 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        refrigerant 17694
          ammonia 17278
            organic amino compound 17278
              amino acid 14879
                aromatic amino acid 3681
                  aminonicotinic acid 14
                    2-aminonicotinic acid 0
                    4-aminonicotinic acid 0
                    5-aminonicotinic acid 0
                    6-aminonicotinic acid + 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        amino acid 14879
                                          aromatic amino acid 3681
                                            aminonicotinic acid 14
                                              2-aminonicotinic acid 0
                                              4-aminonicotinic acid 0
                                              5-aminonicotinic acid 0
                                              6-aminonicotinic acid + 14
paths to the root