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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,8-diaminooctane
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Accession:CHEBI:73112 term browser browse the term
Definition:An alkane-alpha,omega-diamine in which the two amino groups are separated by eight methylene groups.
Synonyms:exact_synonym: octane-1,8-diamine
 related_synonym: 1,8-Octamethylenediamine;   1,8-Octylenediamine;   1,8-octanediamine;   Formula=C8H20N2;   InChI=1S/C8H20N2/c9-7-5-3-1-2-4-6-8-10/h1-10H2;   InChIKey=PWGJDPKCLMLPJW-UHFFFAOYSA-N;   Octamethylenediamine;   SMILES=NCCCCCCCCN;   alpha,omega-diaminooctane
 xref: CAS:373-44-4;   MetaCyc:18-DIAMINOOCTANE;   Reaxys:1735426



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WIN 18446 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases activity EXP
ISO
N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine results in decreased activity of ALDH1A2 protein CTD PMID:12547725 PMID:30958995 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Hopx HOP homeobox multiple interactions ISO [nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of HOPX mRNA; [nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of HOPX protein CTD PMID:30995255 NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA] CTD PMID:23696197 NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO [nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in increased expression of ID2 mRNA CTD PMID:30995255 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Pdpn podoplanin multiple interactions ISO [nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of PDPN mRNA; [nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of PDPN protein CTD PMID:30995255 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        xenobiotic 18436
          octane 2258
            1,8-diaminooctane 5
              WIN 18446 5
              guazatine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        polyamine 8277
                                          diamine 8205
                                            primary diamine 5677
                                              alkane-alpha,omega-diamine 3762
                                                1,8-diaminooctane 5
                                                  WIN 18446 5
                                                  guazatine 0
paths to the root