CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: madecassic acid
Accession: CHEBI:73058
browse the term
Definition: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).
Synonyms: exact_synonym: (2alpha,3beta,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oic acid
related_synonym: 6beta-hydroxyasiatic acid; Formula=C30H48O6; InChI=1S/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30+/m1/s1; InChIKey=PRAUVHZJPXOEIF-AOLYGAPISA-N; SMILES=[H][C@]12CC=C3[C@]4([H])[C@@H](C)[C@H](C)CC[C@@]4(CC[C@@]3(C)[C@]1(C)C[C@@H](O)[C@@]1([H])[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]21C)C(O)=O; brahmic acid
xref: CAS:18449-41-7; HMDB:HMDB0036670; PMID:22816768; PMID:22966846; PMID:23346217; Patent:CN101991578; Patent:FR2963553; Patent:TW200938215; Reaxys:3041357
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX mRNA] madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD
PMID:37087747
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]
CTD
PMID:37087747
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]
CTD
PMID:37087747
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
madecassoside results in decreased activity of CYP2C19 protein
CTD
PMID:21349323
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
madecassoside results in decreased activity of CYP3A4 protein
CTD
PMID:21349323
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA]
CTD
PMID:37087747
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Il1b
interleukin 1 beta
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA]
CTD
PMID:37087747
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA]
CTD
PMID:37087747
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Lcn2
lipocalin 2
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 protein]
CTD
PMID:37087747
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:37087747
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein]
CTD
PMID:37087747
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Tnf
tumor necrosis factor
multiple interactions
ISO
madecassoside inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]
CTD
PMID:37087747
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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