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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lumiracoxib
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Accession:CHEBI:73044 term browser browse the term
Definition:An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
Synonyms:exact_synonym: {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
 related_synonym: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid;   COX 189;   COX189;   Formula=C15H13ClFNO2;   InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20);   InChIKey=KHPKQFYUPIUARC-UHFFFAOYSA-N;   Prexige;   SMILES=Cc1ccc(Nc2c(F)cccc2Cl)c(CC(O)=O)c1;   lumiracoxibum
 xref: CAS:220991-20-8;   DrugBank:DB01283;   Drug_Central:1618;   HMDB:HMDB0015403;   KEGG:D03714
 xref_mesh: MESH:C473384
 xref: PDBeChem:LUR;   PMID:14965322;   PMID:15311562;   PMID:15456339;   PMID:17380211;   PMID:19800190;   PMID:21688392;   PMID:22069133;   PMID:22142375;   PMID:22621454;   PMID:22732767;   Reaxys:9784107;   Wikipedia:Lumiracoxib


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lumiracoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO lumiracoxib results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Ereg epiregulin increases expression ISO lumiracoxib results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Il1b interleukin 1 beta increases expression ISO lumiracoxib results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 increases expression ISO lumiracoxib results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO lumiracoxib results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO lumiracoxib results in decreased activity of PTGS2 protein CTD PMID:17164136 PMID:17661736 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G RT1-Ba RT1 class II, locus Ba affects response to substance ISO HLA-DQA1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects response to substance ISO HLA-DQB1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects response to substance ISO HLA-DRB1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO lumiracoxib results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:111,495,443...111,577,320
Ensembl chr 8:111,495,331...111,577,833
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO lumiracoxib results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        anti-inflammatory agent 15771
          anti-inflammatory drug 13626
            non-steroidal anti-inflammatory drug 12719
              lumiracoxib 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        monocarboxylic acid 17530
                                          lumiracoxib 12
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