Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lumiracoxib
go back to main search page
Accession:CHEBI:73044 term browser browse the term
Definition:An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
Synonyms:exact_synonym: {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
 related_synonym: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid;   COX 189;   COX189;   Formula=C15H13ClFNO2;   InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20);   InChIKey=KHPKQFYUPIUARC-UHFFFAOYSA-N;   Prexige;   SMILES=Cc1ccc(Nc2c(F)cccc2Cl)c(CC(O)=O)c1;   lumiracoxibum
 xref: CAS:220991-20-8;   DrugBank:DB01283;   Drug_Central:1618;   HMDB:HMDB0015403;   KEGG:D03714
 xref_mesh: MESH:C473384
 xref: PDBeChem:LUR;   PMID:14965322;   PMID:15311562;   PMID:15456339;   PMID:17380211;   PMID:19800190;   PMID:21688392;   PMID:22069133;   PMID:22142375;   PMID:22621454;   PMID:22732767;   Reaxys:9784107;   Wikipedia:Lumiracoxib



show annotations for term's descendants           Sort by:
 
lumiracoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO lumiracoxib results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ereg epiregulin increases expression ISO lumiracoxib results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il1b interleukin 1 beta increases expression ISO lumiracoxib results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO lumiracoxib results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO lumiracoxib results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO lumiracoxib results in decreased activity of PTGS2 protein CTD PMID:17164136 PMID:17661736 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G RT1-Ba RT1 class II, locus Ba affects response to substance ISO HLA-DQA1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects response to substance ISO HLA-DQB1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects response to substance ISO HLA-DRB1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO lumiracoxib results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO lumiracoxib results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        anti-inflammatory agent 16435
          anti-inflammatory drug 14849
            non-steroidal anti-inflammatory drug 14216
              lumiracoxib 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        monocarboxylic acid 17840
                                          lumiracoxib 12
paths to the root