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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:parecoxib
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Accession:CHEBI:73038 term browser browse the term
Definition:An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib.
Synonyms:exact_synonym: N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide
 related_synonym: Formula=C19H18N2O4S;   InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22);   InChIKey=TZRHLKRLEZJVIJ-UHFFFAOYSA-N;   N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide;   SC-69124;   SMILES=CCC(=O)NS(=O)(=O)c1ccc(cc1)-c1c(C)onc1-c1ccccc1;   parecoxibum
 xref: CAS:198470-84-7;   Drug_Central:2063;   KEGG:D02709;   LINCS:LSM-5316
 xref_mesh: MESH:C409945
 xref: PDBeChem:PXB;   Reaxys:8640266;   Wikipedia:Parecoxib


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parecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH1 cadherin 1 increases expression EXP parecoxib results in increased expression of CDH1 protein CTD PMID:35917206 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CNR1 cannabinoid receptor 1 increases response to substance ISO CNR1 protein results in increased susceptibility to parecoxib CTD PMID:23371449 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP parecoxib results in decreased expression of CTNNB1 protein CTD PMID:35917206 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases expression
decreases expression		 EXP parecoxib results in increased expression of GSK3B protein
parecoxib results in decreased expression of GSK3B protein modified form		 CTD PMID:35917206 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G MACC1 MET transcriptional regulator MACC1 decreases expression EXP parecoxib results in decreased expression of MACC1 protein CTD PMID:35917206 NCBI chr 7:20,134,655...20,217,384
Ensembl chr 7:20,134,655...20,217,404 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP parecoxib results in decreased phosphorylation of MAPK1 protein CTD PMID:35917206 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP parecoxib results in decreased phosphorylation of MAPK3 protein CTD PMID:35917206 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP parecoxib results in increased phosphorylation of MAPK8 protein CTD PMID:35917206 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP parecoxib results in increased phosphorylation of MAPK9 protein CTD PMID:35917206 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase decreases expression EXP parecoxib results in decreased expression of MET protein CTD PMID:35917206 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
G VIM vimentin decreases expression EXP parecoxib results in decreased expression of VIM protein CTD PMID:35917206 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        pro-agent 12063
          prodrug 11742
            parecoxib 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  heteroarene 18790
                                    monocyclic heteroarene 16149
                                      azole 15707
                                        oxazole 3823
                                          isoxazoles 3304
                                            valdecoxib 727
                                              parecoxib 11
paths to the root