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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:O-acetylcarnitine
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Accession:CHEBI:73024 term browser browse the term
Definition:An O-acylcarnitine having acetyl as the acyl substituent.
Synonyms:exact_synonym: 3-(acetyloxy)-4-(trimethylazaniumyl)butanoate
 related_synonym: 3-acetyloxy-4-trimethylammonio-butanoate;   Acetyl-DL-carnitine;   DL-O-Acetylcarnitine;   Formula=C9H17NO4;   InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3;   InChIKey=RDHQFKQIGNGIED-UHFFFAOYSA-N;   SMILES=CC(=O)OC(CC([O-])=O)C[N+](C)(C)C;   acetylcarnitine
 xref: CAS:870-77-9;   PMID:23315938;   Reaxys:4136458
 cyclic_relationship: is_conjugate_base_of CHEBI:15960

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O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Acetylcarnitine inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Acetylcarnitine inhibits the reaction [Dexamethasone results in increased activity of ACHE protein] CTD PMID:21986892 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases expression EXP Acetylcarnitine results in increased expression of ATP6V1F mRNA CTD PMID:14654561 NCBI chr 4:56,744,563...56,747,657
Ensembl chr 4:56,744,561...56,747,656 		JBrowse link
G C1qa complement C1q A chain decreases expression ISO Acetylcarnitine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143 		JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO Acetylcarnitine results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of CASP3 mRNA] CTD PMID:20067779 PMID:29278859 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:29278859 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of CAT mRNA] CTD PMID:20067779 PMID:26349760 PMID:29278859 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Ctss cathepsin S decreases expression ISO Acetylcarnitine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO Acetylcarnitine results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of EGR1 mRNA] CTD PMID:20067779 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Acetylcarnitine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein] CTD PMID:26265018 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA] CTD PMID:21986892 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA] CTD PMID:21986892 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] CTD PMID:21986892 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP Acetylcarnitine results in decreased expression of HSPB1 mRNA CTD PMID:14654561 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of Acetylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:29278859 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:29278859 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression EXP Acetylcarnitine results in increased expression of MGST1 mRNA CTD PMID:14654561 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions EXP Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] CTD PMID:20067779 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Acetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein] CTD PMID:14654561 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA] CTD PMID:21986892 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA] CTD PMID:21986892 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Acetylcarnitine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions		 ISO Acetylcarnitine results in increased expression of PPARGC1A protein
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein		 CTD PMID:20414966 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Psmb6 proteasome 20S subunit beta 6 increases expression EXP Acetylcarnitine results in increased expression of PSMB6 mRNA CTD PMID:14654561 NCBI chr10:57,131,339...57,133,685
Ensembl chr10:57,131,386...57,133,637 		JBrowse link
G Ptma prothymosin alpha increases expression EXP Acetylcarnitine results in increased expression of PTMA mRNA CTD PMID:14654561 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of RELA protein] CTD PMID:29278859 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rps17 ribosomal protein S17 increases expression EXP Acetylcarnitine results in increased expression of RPS17 mRNA CTD PMID:14654561 NCBI chr 1:143,167,329...143,169,915
Ensembl chr 1:143,167,362...143,169,657 		JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO Acetylcarnitine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Acetylcarnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] CTD PMID:23402788 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734 		JBrowse link
G Snca synuclein alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Acetylcarnitine inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        food additive 14736
          food acidity regulator 11689
            acetic acid 10821
              O-acetylcarnitine 38
                O-acetyl-D-carnitine 0
                O-acetyl-L-carnitine 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            inorganic hydride 17483
                              pnictogen hydride 17456
                                nitrogen hydride 17300
                                  ammonium 8230
                                    ammonium ion derivative 8226
                                      quaternary ammonium ion 5094
                                        quaternary nitrogen compound 570
                                          ammonium betaine 285
                                            amino-acid betaine 191
                                              carnitine 81
                                                O-acylcarnitine 43
                                                  O-acetylcarnitine 38
                                                    O-acetyl-D-carnitine 0
                                                    O-acetyl-L-carnitine 38
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