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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:demethoxyfumitremorgin C
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Accession:CHEBI:72767 term browser browse the term
Definition:An organic heteropentacyclic compound that is a mycotoxic indole alkaloid, consisting of fumitremorgin C lacking the 9-methoxy substituent.
Synonyms:exact_synonym: (5aS,12S,14aS)-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
 related_synonym: Formula=C21H23N3O2;   InChI=1S/C21H23N3O2/c1-12(2)10-17-19-14(13-6-3-4-7-15(13)22-19)11-18-20(25)23-9-5-8-16(23)21(26)24(17)18/h3-4,6-7,10,16-18,22H,5,8-9,11H2,1-2H3/t16-,17-,18-/m0/s1;   InChIKey=LQXCSIKDOISJTI-BZSNNMDCSA-N;   SMILES=[H][C@@]12CCCN1C(=O)[C@]1([H])Cc3c([nH]c4ccccc34)[C@H](C=C(C)C)N1C2=O
 xref: HMDB:HMDB0029565
 xref_mesh: MESH:C100698
 xref: PMID:19226505;   PMID:8698634;   PMID:8698635;   Reaxys:4719119


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demethoxyfumitremorgin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of AKT1 protein CTD PMID:28359723 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO demethoxyfumitremorgin C results in increased expression of BAX protein CTD PMID:28359723 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2 protein CTD PMID:28359723 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2L1 protein CTD PMID:28359723 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Casp3 caspase 3 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP3 protein CTD PMID:28359723 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP8 protein CTD PMID:28359723 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP9 protein CTD PMID:28359723 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO demethoxyfumitremorgin C results in increased cleavage of PARP1 protein CTD PMID:28359723 NCBI chr13:92,307,593...92,339,406 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        poison 18164
          toxin 15339
            mycotoxin 12240
              demethoxyfumitremorgin C 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  organic heteropolycyclic compound 18048
                                    organic heteropentacyclic compound 13358
                                      demethoxyfumitremorgin C 8
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