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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:demethoxyfumitremorgin C
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Accession:CHEBI:72767 term browser browse the term
Definition:An organic heteropentacyclic compound that is a mycotoxic indole alkaloid, consisting of fumitremorgin C lacking the 9-methoxy substituent.
Synonyms:exact_synonym: (5aS,12S,14aS)-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
 related_synonym: Formula=C21H23N3O2;   InChI=1S/C21H23N3O2/c1-12(2)10-17-19-14(13-6-3-4-7-15(13)22-19)11-18-20(25)23-9-5-8-16(23)21(26)24(17)18/h3-4,6-7,10,16-18,22H,5,8-9,11H2,1-2H3/t16-,17-,18-/m0/s1;   InChIKey=LQXCSIKDOISJTI-BZSNNMDCSA-N;   SMILES=[H][C@@]12CCCN1C(=O)[C@]1([H])Cc3c([nH]c4ccccc34)[C@H](C=C(C)C)N1C2=O
 xref: HMDB:HMDB0029565
 xref_mesh: MESH:C100698
 xref: PMID:19226505;   PMID:8698634;   PMID:8698635;   Reaxys:4719119



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demethoxyfumitremorgin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of AKT1 protein CTD PMID:28359723 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO demethoxyfumitremorgin C results in increased expression of BAX protein CTD PMID:28359723 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2 protein CTD PMID:28359723 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2L1 protein CTD PMID:28359723 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP3 protein CTD PMID:28359723 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP8 protein CTD PMID:28359723 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP9 protein CTD PMID:28359723 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO demethoxyfumitremorgin C results in increased cleavage of PARP1 protein CTD PMID:28359723 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19714
      biological role 19712
        poison 18477
          toxin 15932
            mycotoxin 11946
              demethoxyfumitremorgin C 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19739
      composite particle 19739
        hadron 19739
          baryon 19739
            nucleon 19739
              atomic nucleus 19739
                atom 19739
                  main group element atom 19687
                    p-block element atom 19687
                      carbon group element atom 19633
                        carbon atom 19629
                          organic molecular entity 19629
                            organic molecule 19588
                              organic cyclic compound 19393
                                organic heterocyclic compound 18758
                                  organic heteropolycyclic compound 18240
                                    organic heteropentacyclic compound 13474
                                      demethoxyfumitremorgin C 8
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