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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flavonolignan
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Accession:CHEBI:72709 term browser browse the term
Definition:Any lignan condensed with a 2-aryl-1-benzopyran skeleton and its substituted derivatives.
Synonyms:related_synonym: flavonolignans
 xref: Wikipedia:Flavonolignan

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silibinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Silybin affects the localization of and affects the activity of ABCB11 protein CTD PMID:15763547 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation		 ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased phosphorylation of ACACA protein]
Silybin results in increased phosphorylation of ACACA protein		 CTD PMID:25294820 PMID:25559859 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acly ATP citrate lyase decreases phosphorylation ISO Silybin results in decreased phosphorylation of ACLY protein CTD PMID:25294820 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP silymarin (silibinin) increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats RGD PMID:26115886 RGD:25330099 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA] CTD PMID:28619387 NCBI chr20:11,060,584...11,144,806
Ensembl chr20:11,114,164...11,144,806 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Silybin results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of AKT1 protein] CTD PMID:25559859 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO Silybin results in decreased expression of AMACR protein CTD PMID:25294820 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326 		JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA] CTD PMID:28619387 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736 		JBrowse link
G Asl argininosuccinate lyase multiple interactions EXP Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein] CTD PMID:28619387 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Silybin results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:16777994 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Silybin inhibits the reaction [Mitomycin affects the localization of BAX protein] CTD PMID:19834285 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Silybin results in decreased expression of BCL2 mRNA
[Silybin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; Silybin inhibits the reaction [Mitomycin affects the expression of BCL2]		 CTD PMID:19834285 PMID:21969006 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
affects localization		 ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of BID protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of BID protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein]
Silybin affects the localization of BID protein modified form		 CTD PMID:16777994 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Silybin co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA CTD PMID:21969006 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Ca9 carbonic anhydrase 9 decreases expression
multiple interactions		 ISO Silybin results in decreased expression of CA9 mRNA
Arsenic Trioxide promotes the reaction [Silybin results in decreased expression of CA9 mRNA]		 CTD PMID:21969006 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528 		JBrowse link
G Casp2 caspase 2 multiple interactions ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; Silybin results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:16777994 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity		 ISO Silybin results in increased expression of CASP3 mRNA
Arsenic Trioxide promotes the reaction [Silybin results in increased activity of CASP3 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Silybin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; Silybin results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:16777994 PMID:21969006 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]; Silybin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16777994 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Silybin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16777994 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP Silybin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Silybin inhibits the reaction [sodium arsenite results in decreased expression of CAT] CTD PMID:22229868 PMID:23070905 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNA2 protein] CTD PMID:25559859 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Silybin inhibits the reaction [Arsenic results in increased expression of CCNB1] CTD PMID:25868784 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCND1 protein]
Silybin results in decreased expression of CCND1 protein
[Silybin co-treated with Arsenic] results in decreased expression of CCND1 protein		 CTD PMID:16788158 PMID:25559859 PMID:25868784 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [Silybin co-treated with Arsenic] results in decreased expression of CCND3 protein CTD PMID:25868784 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Silybin inhibits the reaction [Arsenic results in increased expression of CDK1 protein] CTD PMID:25868784 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [Silybin co-treated with Arsenic] results in decreased expression of CDK2 protein CTD PMID:25868784 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [Silybin co-treated with Arsenic] results in decreased expression of CDK4 protein CTD PMID:25868784 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [Silybin co-treated with Arsenic] results in decreased expression of CDK6 protein CTD PMID:25868784 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases cleavage		 ISO [Silybin co-treated with Arsenic] results in increased expression of CDKN1A protein; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of CDKN1A protein] CTD PMID:16777994 PMID:25868784 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]
[Silybin co-treated with Arsenic] results in increased expression of CDKN1B protein		 CTD PMID:25559859 PMID:25868784 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:25559859 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions		 ISO Silybin results in increased phosphorylation of CHEK2 protein
Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]		 CTD PMID:16777994 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Arsenic Trioxide co-treated with Silybin] results in decreased expression of CTSB mRNA CTD PMID:21969006 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA] CTD PMID:28619387 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in increased expression of CYBB] CTD PMID:24062023 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Silybin results in decreased activity of CYP2C8 protein CTD PMID:28457856 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
multiple interactions		 ISO Silybin results in decreased activity of CYP3A4 protein
Silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]		 CTD PMID:15155549 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO DDIT3 affects the reaction [Silybin results in increased expression of TNFRSF10B] CTD PMID:19939880 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA] CTD PMID:25559859 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751 		JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions		 ISO Silybin results in increased expression of EGR1 protein
EGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]		 CTD PMID:24440808 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP
ISO		 Silybin results in increased activity of [ESR1 protein binds to ESR2 protein] CTD PMID:16076518 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO
EXP		 Silybin results in increased activity of [ESR1 protein binds to ESR2 protein] CTD PMID:16076518 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein] CTD PMID:25559859 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression		 ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]
Silybin results in decreased expression of FASN protein		 CTD PMID:25294820 PMID:25559859 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Silybin inhibits the reaction [Urethane results in increased secretion of FGF2 protein] CTD PMID:16788158 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Silybin inhibits the reaction [Arsenic results in decreased activity of G6PD protein] CTD PMID:22229868 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO Silybin results in increased expression of GDF15 mRNA; Silybin results in increased expression of GDF15 protein
EGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]; GDF15 mutant form inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pyrazolanthrone promotes the reaction [Silybin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [Silybin results in increased expression of GDF15 protein]		 CTD PMID:24440808 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]] CTD PMID:28619387 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Silybin inhibits the reaction [Arsenic results in decreased activity of GSR protein] CTD PMID:22229868 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation		 ISO Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein] CTD PMID:16777994 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Silybin results in decreased expression of HMGCR protein CTD PMID:25294820 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1] CTD PMID:24062023 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Klf2 Kruppel-like factor 2 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA] CTD PMID:25559859 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037 		JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA] CTD PMID:25559859 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669 		JBrowse link
G Klf5 Kruppel-like factor 5 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA] CTD PMID:25559859 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921 		JBrowse link
G Lpin1 lipin 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 protein] CTD PMID:25559859 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:25559859 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:25559859 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Silybin results in increased phosphorylation of MAPK8 protein
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]		 CTD PMID:16777994 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 ISO pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein] CTD PMID:16777994 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO Silybin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP14 mRNA; Arsenic Trioxide inhibits the reaction [Silybin results in increased expression of MMP14 mRNA] CTD PMID:21969006 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions		 ISO
EXP		 Silybin results in increased expression of MMP2 mRNA
[Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]
[Arsenic Trioxide co-treated with Silybin] results in decreased activity of MMP2 protein; [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP2 mRNA; [Silybin co-treated with Arsenic] results in decreased expression of MMP2; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]		 CTD PMID:16169303 PMID:21969006 PMID:25868784 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
decreases activity		 ISO Silybin results in decreased expression of MMP9 mRNA
[Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP9 mRNA; [Silybin co-treated with Arsenic Trioxide] results in decreased activity of MMP9 protein
Silybin results in decreased activity of MMP9 protein		 CTD PMID:21969006 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Silybin results in decreased expression of MYC protein CTD PMID:27746612 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA] CTD PMID:28619387 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2] CTD PMID:24062023 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Silybin inhibits the reaction [sodium arsenite results in increased expression of NOS2]
Silybin results in decreased expression of NOS2 protein		 CTD PMID:16788158 PMID:23070905 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in increased expression of NOX4] CTD PMID:24062023 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions		 IEP
ISO		 Silymarin decreases Nqo1 mRNA in liver
Silybin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]		 CTD PMID:31330490, PMID:31432116 RGD:25823187 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP silymarin increases Nr1h4 mRNA expression in rat kidney and liver RGD PMID:30308196 RGD:15042865 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO Silybin results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Silybin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; GDF15 mutant form inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; Silybin results in increased cleavage of and results in increased activity of PARP1 protein		 CTD PMID:16777994 PMID:24440808 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Silybin results in decreased expression of PCNA protein CTD PMID:16788158 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Silybin results in decreased expression of PECAM1 protein CTD PMID:16788158 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases expression		 ISO [Silybin co-treated with Arsenic Trioxide] results in decreased expression of PLAU mRNA; Arsenic Trioxide promotes the reaction [Silybin results in decreased expression of PLAU mRNA]; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of PLAU mRNA] CTD PMID:21969006 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA] CTD PMID:28619387 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]
Silybin results in increased expression of PPARG protein		 CTD PMID:25559859 PMID:27746612 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Silybin results in decreased expression of PTGS2 protein CTD PMID:16788158 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RB1 protein] CTD PMID:25559859 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Silybin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid] CTD PMID:17976262 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Silybin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases response to substance		 ISO fatostatin promotes the reaction [Silybin results in decreased cleavage of SREBF1 protein]; Silybin results in decreased cleavage of and results in increased phosphorylation of SREBF1 protein
SREBF1 protein results in decreased susceptibility to Silybin		 CTD PMID:25294820 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein] CTD PMID:28619387 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization
increases phosphorylation
increases expression		 ISO Caffeine inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; Silybin inhibits the reaction [Mitomycin results in increased expression of TP53]
Silybin affects the localization of TP53 protein
Silybin results in increased expression of TP53 protein		 CTD PMID:16777994 PMID:19834285 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity
multiple interactions		 EXP
ISO		 Silybin metabolite results in decreased activity of UGT1A1 protein
Silybin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]		 CTD PMID:15155549 PMID:15921999 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
decreases activity		 ISO
EXP		 Silybin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]
Silybin metabolite results in decreased activity of UGT1A6 protein		 CTD PMID:15155549 PMID:15921999 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO Silybin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin] CTD PMID:15155549 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Silybin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin] CTD PMID:15155549 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO Silybin promotes the reaction [Lipids deficiency inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]]; Silybin promotes the reaction [Lipids deficiency results in decreased expression of VEGFA protein]
Silybin results in decreased expression of VEGFA protein
Silybin inhibits the reaction [Urethane results in increased secretion of VEGFA protein]		 CTD PMID:16788158 PMID:26087400 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vim vimentin multiple interactions ISO [Silybin co-treated with Arsenic] results in decreased expression of VIM CTD PMID:25868784 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
silychristin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO silychristin results in decreased activity of CA1 protein CTD PMID:28445001 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO silychristin results in decreased activity of CA2 protein CTD PMID:28445001 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    chemical entity 19817
      atom 19815
        nonmetal atom 19694
          oxygen atom 19368
            oxygen molecular entity 19368
              flavonoids 10519
                flavonolignan 98
                  (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                  (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                  (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                  (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                  3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one 0
                  5''-methoxyhydnocarpin-D 0
                  isosilybin 0
                  silandrin 0
                  silibinin 96
                  silychristin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic molecule 19532
                              organic cyclic compound 19348
                                organic heterocyclic compound 18475
                                  oxacycle 17289
                                    benzopyran 10155
                                      1-benzopyran 9871
                                        flavonolignan 98
                                          (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one 0
                                          5''-methoxyhydnocarpin-D 0
                                          isosilybin 0
                                          silandrin 0
                                          silibinin 96
                                          silychristin 2
paths to the root