CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: chromenyliums
Accession: CHEBI:72704
browse the term
Definition: Any organic cation that consists of a chromenylium skeleton and its substituted derivatives thereof.
Synonyms: related_synonym: benzopyryliums
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Acta2
actin alpha 2, smooth muscle
multiple interactions decreases expression
ISO EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 protein] Anthocyanins results in decreased expression of ACTA2 mRNA; Anthocyanins results in decreased expression of ACTA2 protein
CTD
PMID:30056145 PMID:30403199
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of AGER protein]
CTD
PMID:24795233
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Atm
ATM serine/threonine kinase
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of ATM protein
CTD
PMID:27444805
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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B2m
beta-2 microglobulin
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of B2M protein]
CTD
PMID:30825423
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Bad
BCL2-associated agonist of cell death
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BAD protein modified form]; Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAD protein]
CTD
PMID:28856781
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bak1
BCL2-antagonist/killer 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAK1 protein]
CTD
PMID:28856781
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX protein]
CTD
PMID:30403199
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
CTD
PMID:28856781 PMID:30403199
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]
CTD
PMID:28856781
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Car1
carbonic anhydrase 1
decreases activity
ISO
Anthocyanins results in decreased activity of CA1 protein
CTD
PMID:28445001
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car2
carbonic anhydrase 2
decreases activity
ISO
Anthocyanins results in decreased activity of CA2 protein
CTD
PMID:28445001
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Casp1
caspase 1
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased activity of CASP1 protein]
CTD
PMID:24795233
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]
CTD
PMID:28856781
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein]
CTD
PMID:28856781
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
CTD
PMID:28856781
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
CTD
PMID:30825423
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]
CTD
PMID:30056145
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccn2
cellular communication network factor 2
decreases expression
ISO
Anthocyanins results in decreased expression of CCN2 mRNA
CTD
PMID:30056145
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccnb1
cyclin B1
increases expression multiple interactions
ISO
Anthocyanins results in increased expression of CCNB1 protein Anthocyanins promotes the reaction [CDK1 protein binds to CCNB1 protein]
CTD
PMID:27444805
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cdc25c
cell division cycle 25C
multiple interactions increases phosphorylation
ISO
Anthocyanins results in decreased expression of and results in increased phosphorylation of CDC25C protein Anthocyanins results in increased phosphorylation of CDC25C protein
CTD
PMID:27444805
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdh1
cadherin 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]
CTD
PMID:30403199
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk1
cyclin-dependent kinase 1
multiple interactions
ISO
Anthocyanins promotes the reaction [CDK1 protein binds to CCNB1 protein]; Anthocyanins results in increased expression of and results in increased phosphorylation of CDK1 protein
CTD
PMID:27444805
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Anthocyanins results in increased expression of CDKN1A protein
CTD
PMID:27444805
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
Anthocyanins results in increased expression of CDKN1B protein
CTD
PMID:27444805
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Chek1
checkpoint kinase 1
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of CHEK1 protein
CTD
PMID:27444805
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2
checkpoint kinase 2
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of CHEK2 protein
CTD
PMID:27444805
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Cldn4
claudin 4
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]
CTD
PMID:25451569
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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Col1a1
collagen type I alpha 1 chain
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]
CTD
PMID:30403199
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col3a1
collagen type III alpha 1 chain
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]
CTD
PMID:30056145
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Ctsd
cathepsin D
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]
CTD
PMID:25451569
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2]
CTD
PMID:30056145
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases expression
EXP
Anthocyanins results in increased expression of CYP2C mRNA
CTD
PMID:18803703
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Anthocyanins results in increased expression of CYP2E1 mRNA
CTD
PMID:18803703
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
EXP
Anthocyanins results in increased expression of CYP3A2 mRNA
CTD
PMID:18803703
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Anthocyanins results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:18803703
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Fadd
Fas associated via death domain
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FADD protein]
CTD
PMID:28856781
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fas
Fas cell surface death receptor
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FAS protein]
CTD
PMID:28856781
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FASLG protein]
CTD
PMID:28856781
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Gsr
glutathione-disulfide reductase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein]
CTD
PMID:30825423
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gusb
glucuronidase, beta
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]
CTD
PMID:25451569
NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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H2ax
H2A.X variant histone
increases phosphorylation
ISO
Anthocyanins results in increased phosphorylation of H2AX protein
CTD
PMID:27444805
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein]
CTD
PMID:30825423
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased phosphorylation of IKBKB protein]
CTD
PMID:24795233
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Il10
interleukin 10
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]
CTD
PMID:25451569
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
multiple interactions
EXP ISO
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein] Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]
CTD
PMID:24795233 PMID:25451569 PMID:30056145
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Lcn2
lipocalin 2
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of LCN2 protein]
CTD
PMID:30825423
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]
CTD
PMID:30056145
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]
CTD
PMID:25451569 PMID:30825423
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased degradation of NFKBIA protein]
CTD
PMID:24795233
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NLRP3 protein]
CTD
PMID:24795233
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein]
CTD
PMID:24795233
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein]
CTD
PMID:28856781
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]
CTD
PMID:30056145
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pde5a
phosphodiesterase 5A
decreases activity
ISO
Anthocyanins results in decreased activity of PDE5A protein
CTD
PMID:15769121
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
increases expression
EXP
Anthocyanins results in increased expression of PIK3R1 mRNA
CTD
PMID:18803703
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pla2g2a
phospholipase A2 group IIA
increases expression
EXP
Anthocyanins results in increased expression of PLA2G2A mRNA
CTD
PMID:18803703
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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Plcd4
phospholipase C, delta 4
increases expression
EXP
Anthocyanins results in increased expression of PLCD4 mRNA
CTD
PMID:18803703
NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
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Por
cytochrome p450 oxidoreductase
increases expression
EXP
Anthocyanins results in increased expression of POR mRNA
CTD
PMID:18803703
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein]
CTD
PMID:24795233
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pycard
PYD and CARD domain containing
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PYCARD protein]
CTD
PMID:24795233
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of RELA protein]
CTD
PMID:25451569
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Smad2
SMAD family member 2
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]
CTD
PMID:30403199
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Snca
synuclein alpha
decreases expression
ISO
Anthocyanins results in decreased expression of SNCA protein
CTD
PMID:29976995
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Tgfb1
transforming growth factor, beta 1
decreases expression multiple interactions
ISO EXP
Anthocyanins results in decreased expression of TGFB1 mRNA Anthocyanins inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]
CTD
PMID:30056145 PMID:30403199
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfbr1
transforming growth factor, beta receptor 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of TGFBR1 protein]
CTD
PMID:30403199
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]
CTD
PMID:30056145
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tjp1
tight junction protein 1
multiple interactions
EXP
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein]
CTD
PMID:25451569
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tnf
tumor necrosis factor
multiple interactions
EXP ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein] Anthocyanins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD
PMID:18720166 PMID:25451569 PMID:30825423
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Txnip
thioredoxin interacting protein
multiple interactions
ISO
Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of TXNIP protein]
CTD
PMID:24795233
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Vim
vimentin
multiple interactions
EXP
Anthocyanins inhibits the reaction [Paraquat results in increased expression of VIM mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of VIM protein]
CTD
PMID:30403199
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xdh
xanthine dehydrogenase
multiple interactions
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased activity of XDH protein]
CTD
PMID:30825423
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Ahr
aryl hydrocarbon receptor
increases activity
ISO
cyanidin results in increased activity of AHR protein
CTD
PMID:23419638
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ccn1
cellular communication network factor 1
multiple interactions
ISO EXP
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CCN1 protein] cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of CCN1 protein]
CTD
PMID:32044269
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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Csf2
colony stimulating factor 2
multiple interactions
EXP ISO
cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of CSF2 protein] cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 protein]
CTD
PMID:32044269
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Hbegf
heparin-binding EGF-like growth factor
multiple interactions
ISO
cyanidin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]
CTD
PMID:26800359
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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Hlcs
holocarboxylase synthetase
decreases activity
ISO
cyanidin results in decreased activity of HLCS protein
CTD
PMID:26303405
NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222
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Hmox1
heme oxygenase 1
affects expression
ISO
cyanidin affects the expression of HMOX1 protein
CTD
PMID:26505893
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il17a
interleukin 17A
multiple interactions
ISO
[cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]] which results in increased expression of PIAS3 protein; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CCN1 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of PCNA protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of TLR3 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK1 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK3 protein]; cyanidin inhibits the reaction [IL17A protein promotes the reaction [Freund's Adjuvant results in increased expression of TLR3 protein]]
CTD
PMID:32044269
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il17ra
interleukin 17 receptor A
multiple interactions
ISO
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA protein]
CTD
PMID:32044269
NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174
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Il23a
interleukin 23 subunit alpha
multiple interactions
ISO EXP
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A protein] cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of IL23A protein]
CTD
PMID:32044269
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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Jak1
Janus kinase 1
multiple interactions
ISO
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK1 protein]
CTD
PMID:32044269
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Jak3
Janus kinase 3
multiple interactions
ISO
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK3 protein]
CTD
PMID:32044269
NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity affects expression
EXP ISO
cyanidin results in increased activity of NFE2L2 protein cyanidin affects the expression of NFE2L2 protein
CTD
PMID:26505893 PMID:27166148
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos3
nitric oxide synthase 3
increases expression
ISO
cyanidin results in increased expression of NOS3 mRNA
CTD
PMID:15740983
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of PCNA protein]
CTD
PMID:32044269
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pdgfa
platelet derived growth factor subunit A
multiple interactions
ISO
cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]
CTD
PMID:16921400
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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Pdgfb
platelet derived growth factor subunit B
multiple interactions
ISO
cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]
CTD
PMID:16921400
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pias3
protein inhibitor of activated STAT, 3
multiple interactions
ISO
[cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]] which results in increased expression of PIAS3 protein
CTD
PMID:32044269
NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO EXP
[cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]] which results in increased expression of PIAS3 protein; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein] cyanidin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of STAT3 protein]
CTD
PMID:32044269
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tlr3
toll-like receptor 3
multiple interactions
ISO EXP
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of TLR3 protein]; cyanidin inhibits the reaction [IL17A protein promotes the reaction [Freund's Adjuvant results in increased expression of TLR3 protein]] cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of TLR3 protein]
CTD
PMID:32044269
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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Tnf
tumor necrosis factor
multiple interactions
ISO
cyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]
CTD
PMID:28533128
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ucp2
uncoupling protein 2
multiple interactions
ISO
cyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]
CTD
PMID:28533128
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]; cyanidin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]
CTD
PMID:16921400 PMID:26800359
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:20371262
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Akr1b7
aldo-keto reductase family 1, member B7
increases expression
ISO
delphinidin results in increased expression of AKR1B7 mRNA
CTD
PMID:38291899
NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of ARNT protein]
CTD
PMID:18603805
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
delphinidin results in increased expression of BAD protein
CTD
PMID:33955636
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
delphinidin results in increased expression of BAK1 protein
CTD
PMID:29451351
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions decreases expression
ISO
delphinidin results in increased expression of BAX protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein] delphinidin results in decreased expression of BAX protein
CTD
PMID:15740068 PMID:19818742 PMID:30365941 PMID:33955636
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions increases expression
ISO
delphinidin results in decreased expression of BCL2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein] delphinidin results in increased expression of BCL2 protein
CTD
PMID:15740068 PMID:19818742 PMID:29451351 PMID:30365941 PMID:33955636
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
delphinidin results in decreased expression of BCL2L1 protein
CTD
PMID:33955636
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bid
BH3 interacting domain death agonist
multiple interactions decreases expression
ISO
[delphinidin results in increased susceptibility to sodium arsenite] which results in decreased expression of BID protein delphinidin results in decreased expression of BID protein
CTD
PMID:25954945 PMID:30125548
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Btg2
BTG anti-proliferation factor 2
affects expression
ISO
delphinidin affects the expression of BTG2 mRNA
CTD
PMID:19182879
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Casp3
caspase 3
increases activity increases expression increases cleavage multiple interactions
ISO
delphinidin results in increased activity of CASP3 protein delphinidin results in increased expression of CASP3 protein delphinidin results in increased cleavage of CASP3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP3 protein; delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]; delphinidin results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:15740068 PMID:25954945 PMID:29451351 PMID:30125548 PMID:30365941 PMID:33955636 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
multiple interactions increases expression
ISO
[delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP8 protein; delphinidin results in increased cleavage of and results in increased activity of CASP8 protein delphinidin results in increased expression of CASP8 protein
CTD
PMID:25954945 PMID:30125548 PMID:33955636
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
multiple interactions increases expression
ISO
[delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP9 protein; delphinidin results in increased cleavage of and results in increased activity of CASP9 protein delphinidin results in increased expression of CASP9 protein
CTD
PMID:25954945 PMID:30125548 PMID:33955636
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases activity
ISO
delphinidin results in decreased activity of CAT protein
CTD
PMID:33955636
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cdh1
cadherin 1
increases expression
ISO
delphinidin results in increased expression of CDH1 protein
CTD
PMID:29451351
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
decreases expression
ISO
delphinidin results in decreased expression of CDH2 protein
CTD
PMID:29451351
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cidea
cell death-inducing DFFA-like effector a
increases expression
ISO
delphinidin results in increased expression of CIDEA mRNA
CTD
PMID:19182879
NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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Crisp1
cysteine-rich secretory protein 1
increases expression
ISO
delphinidin results in increased expression of CRISP1 mRNA
CTD
PMID:38291899
NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796
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Cst8
cystatin 8
decreases expression
ISO
delphinidin results in decreased expression of CST8 mRNA
CTD
PMID:38291899
NCBI chr 3:136,244,586...136,255,412
Ensembl chr 3:136,244,636...136,251,273
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Cycs
cytochrome c, somatic
increases expression
ISO
delphinidin results in increased expression of CYCS protein
CTD
PMID:33955636
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
delphinidin results in decreased activity of CYP1A1 protein
CTD
PMID:23419638
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Defb43
defensin beta 43
increases expression
ISO
delphinidin results in increased expression of DEFB43 mRNA
CTD
PMID:38291899
NCBI chr15:37,271,888...37,276,782
Ensembl chr15:37,272,008...37,276,626
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Dkkl1
dickkopf like acrosomal protein 1
decreases expression
ISO
delphinidin results in decreased expression of DKKL1 mRNA
CTD
PMID:38291899
NCBI chr 1:95,694,010...95,699,259
Ensembl chr 1:95,694,010...95,699,259
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Egfr
epidermal growth factor receptor
decreases phosphorylation
ISO
delphinidin results in decreased phosphorylation of EGFR protein
CTD
PMID:18618485
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Epas1
endothelial PAS domain protein 1
multiple interactions
ISO
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of EPAS1 protein]
CTD
PMID:18603805
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Erbb2
erb-b2 receptor tyrosine kinase 2
decreases phosphorylation
ISO
delphinidin results in decreased phosphorylation of ERBB2 protein
CTD
PMID:18618485
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Fam3b
FAM3 metabolism regulating signaling molecule B
decreases expression
ISO
delphinidin results in decreased expression of FAM3B mRNA
CTD
PMID:38291899
NCBI chr11:36,831,532...36,863,902
Ensembl chr11:36,831,532...36,869,713
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Fam3d
FAM3 metabolism regulating signaling molecule D
decreases expression
ISO
delphinidin results in decreased expression of FAM3D mRNA; delphinidin results in decreased expression of FAM3D protein
CTD
PMID:38291899
NCBI chr15:16,538,881...16,574,468
Ensembl chr15:16,539,489...16,573,034
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]
CTD
PMID:18603805
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hif3a
hypoxia inducible factor 3 subunit alpha
multiple interactions
ISO
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF3A protein]
CTD
PMID:18603805
NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
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Hmox1
heme oxygenase 1
increases expression
EXP
delphinidin results in increased expression of HMOX1 protein
CTD
PMID:30266311
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Jak2
Janus kinase 2
decreases phosphorylation
ISO
delphinidin results in decreased phosphorylation of JAK2 protein
CTD
PMID:33955636
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
delphinidin results in increased expression of JUN mRNA
CTD
PMID:15740068
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
delphinidin results in decreased phosphorylation of MAPK1 protein
CTD
PMID:18618485 PMID:29451351 PMID:33955636
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
delphinidin results in decreased phosphorylation of MAPK3 protein
CTD
PMID:18618485 PMID:29451351 PMID:33955636
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
delphinidin results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD
PMID:15740068
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
delphinidin promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 protein]
CTD
PMID:20371262
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nbn
nibrin
increases expression
ISO
delphinidin results in increased expression of NBN mRNA
CTD
PMID:19182879
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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Parp1
poly (ADP-ribose) polymerase 1
decreases activity increases cleavage
ISO
delphinidin results in decreased activity of PARP1 protein delphinidin results in increased cleavage of PARP1 protein
CTD
PMID:17884996 PMID:29451351
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcbp4
poly(rC) binding protein 4
affects expression
ISO
delphinidin affects the expression of PCBP4 mRNA
CTD
PMID:19182879
NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276
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Pdgfa
platelet derived growth factor subunit A
multiple interactions
ISO
delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]
CTD
PMID:16921400
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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Pdgfb
platelet derived growth factor subunit B
multiple interactions
ISO
delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]
CTD
PMID:16921400
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pgk1
phosphoglycerate kinase 1
multiple interactions
ISO
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein]
CTD
PMID:18603805
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
delphinidin results in increased expression of PTGS2 mRNA
CTD
PMID:38291899
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Serpina1f
serpin family A member 1F
increases expression
ISO
delphinidin results in increased expression of SERPINA1F mRNA
CTD
PMID:38291899
NCBI chr 6:122,820,752...122,827,112
Ensembl chr 6:122,820,907...122,827,112
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Snai1
snail family transcriptional repressor 1
decreases expression
ISO
delphinidin results in decreased expression of SNAI1 protein
CTD
PMID:29451351
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Snai2
snail family transcriptional repressor 2
decreases expression
ISO
delphinidin results in decreased expression of SNAI2 protein
CTD
PMID:29451351
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Stat3
signal transducer and activator of transcription 3
decreases phosphorylation
ISO
delphinidin results in decreased phosphorylation of STAT3 protein
CTD
PMID:33955636
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]; delphinidin inhibits the reaction [TGFB1 results in increased abundance of Malondialdehyde]; delphinidin inhibits the reaction [TGFB1 results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]; delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]
CTD
PMID:20371262 PMID:30365941
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Themis3
thymocyte selection associated family member 3
decreases expression
ISO
delphinidin results in decreased expression of THEMIS3 mRNA
CTD
PMID:38291899
NCBI chr 9:106,543,112...106,580,780
Ensembl chr 9:106,543,723...106,580,907
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Tnf
tumor necrosis factor
multiple interactions
ISO
delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD
PMID:20371262
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Top1
DNA topoisomerase I
decreases activity
ISO
delphinidin results in decreased activity of TOP1 protein
CTD
PMID:19182879
NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
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Top2a
DNA topoisomerase II alpha
decreases activity multiple interactions
ISO
delphinidin results in decreased activity of TOP2A protein delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein]; delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein]
CTD
PMID:19182879
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]
CTD
PMID:16921400
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
increases expression
EXP
luteolinidin results in increased expression of HSD17B7 mRNA
CTD
PMID:31201582
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
G
Nfe2
nuclear factor, erythroid 2
increases expression
EXP
luteolinidin results in increased expression of NFE2 mRNA
CTD
PMID:31201582
NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
malvidin promotes the reaction [[endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein]; malvidin promotes the reaction [endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD
PMID:23755222
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
malvidin results in increased expression of BAX protein
CTD
PMID:15964118
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
malvidin results in decreased expression of BCL2 protein
CTD
PMID:15964118
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
increases activity multiple interactions
ISO
malvidin results in increased activity of CASP3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [malvidin results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [malvidin results in increased activity of CASP3 protein]
CTD
PMID:15964118
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Dusp1
dual specificity phosphatase 1
multiple interactions
ISO
malvidin promotes the reaction [endotoxin, Escherichia coli results in increased expression of DUSP1 mRNA]; malvidin promotes the reaction [endotoxin, Escherichia coli results in increased expression of DUSP1 protein]
CTD
PMID:23755222
NCBI chr10:16,680,478...16,683,275
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
malvidin promotes the reaction [[endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein]
CTD
PMID:23755222
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
malvidin results in decreased phosphorylation of MAPK1 protein
CTD
PMID:15964118
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
malvidin results in increased expression of and results in increased phosphorylation of MAPK14 protein
CTD
PMID:15964118
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
malvidin results in decreased phosphorylation of MAPK3 protein
CTD
PMID:15964118
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
malvidin results in increased cleavage of PARP1 protein
CTD
PMID:15964118
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pde5a
phosphodiesterase 5A
decreases activity
ISO
malvidin results in decreased activity of PDE5A protein
CTD
PMID:15769121
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
G
Pdgfa
platelet derived growth factor subunit A
multiple interactions
ISO
malvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]
CTD
PMID:16921400
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
G
Pdgfb
platelet derived growth factor subunit B
multiple interactions
ISO
malvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]
CTD
PMID:16921400
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
malvidin inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]
CTD
PMID:23755222
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Aqp3
aquaporin 3 (Gill blood group)
multiple interactions
ISO
[malvidin-3-glucoside co-treated with petunidin-3-glucoside] results in increased expression of AQP3 mRNA
CTD
PMID:33294640
NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
G
Car1
carbonic anhydrase 1
decreases activity
ISO
malvidin-3-glucoside results in decreased activity of CA1 protein
CTD
PMID:28445001
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
malvidin-3-glucoside results in decreased activity of CA2 protein
CTD
PMID:28445001
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
malvidin-3-glucoside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:23731018
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Pde5a
phosphodiesterase 5A
decreases activity
ISO
malvidin-3-glucoside results in decreased activity of PDE5A protein
CTD
PMID:15769121
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
G
Sele
selectin E
multiple interactions
ISO
malvidin-3-glucoside inhibits the reaction [TNF protein results in increased expression of SELE protein]
CTD
PMID:30611791
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
G
Tnf
tumor necrosis factor
multiple interactions
ISO
malvidin-3-glucoside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] malvidin-3-glucoside inhibits the reaction [TNF protein results in increased expression of SELE protein]
CTD
PMID:23731018 PMID:30611791
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Car1
carbonic anhydrase 1
decreases activity
ISO
malvin results in decreased activity of CA1 protein
CTD
PMID:28445001
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
malvin results in decreased activity of CA2 protein
CTD
PMID:28445001
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Ahr
aryl hydrocarbon receptor
increases activity multiple interactions
ISO
pelargonidin metabolite results in increased activity of AHR protein [pelargonidin metabolite results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; pelargonidin binds to and results in increased activity of AHR protein
CTD
PMID:23419638 PMID:23735880
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Cdh1
cadherin 1
multiple interactions
ISO
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 mRNA]; pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 protein]
CTD
PMID:30753810
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity increases expression multiple interactions
ISO
pelargonidin metabolite results in decreased activity of CYP1A1 protein; pelargonidin results in decreased activity of CYP1A1 protein pelargonidin metabolite results in increased expression of CYP1A1 mRNA; pelargonidin results in increased expression of CYP1A1 mRNA [pelargonidin metabolite results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; pelargonidin results in increased expression of and results in increased activity of CYP1A1 protein
CTD
PMID:23419638 PMID:23735880
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
pelargonidin results in increased expression of CYP1A2 mRNA
CTD
PMID:23419638
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Dnmt1
DNA methyltransferase 1
decreases expression
ISO
pelargonidin results in decreased expression of DNMT1 protein
CTD
PMID:31181187
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
G
Dnmt3b
DNA methyltransferase 3 beta
decreases expression
ISO
pelargonidin results in decreased expression of DNMT3B protein
CTD
PMID:31181187
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
G
Hdac1
histone deacetylase 1
decreases expression
ISO
pelargonidin results in decreased expression of HDAC1 protein
CTD
PMID:31181187
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
G
Hdac2
histone deacetylase 2
decreases expression
ISO
pelargonidin results in decreased expression of HDAC2 protein
CTD
PMID:31181187
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
G
Hdac3
histone deacetylase 3
decreases expression
ISO
pelargonidin results in decreased expression of HDAC3 protein
CTD
PMID:31181187
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
G
Hdac4
histone deacetylase 4
decreases expression
ISO
pelargonidin results in decreased expression of HDAC4 protein
CTD
PMID:31181187
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
G
Hdac7
histone deacetylase 7
decreases expression
ISO
pelargonidin results in decreased expression of HDAC7 protein
CTD
PMID:31181187
NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
G
Hmox1
heme oxygenase 1
increases expression
ISO
pelargonidin results in increased expression of HMOX1 mRNA; pelargonidin results in increased expression of HMOX1 protein
CTD
PMID:31181187
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 mRNA]; pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein]
CTD
PMID:30753810
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Il6
interleukin 6
multiple interactions
ISO
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
CTD
PMID:30753810
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]
CTD
PMID:30753810
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]
CTD
PMID:30753810
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Nfe2l2
NFE2 like bZIP transcription factor 2
decreases methylation affects response to substance
ISO
pelargonidin results in decreased methylation of NFE2L2 promoter NFE2L2 protein affects the susceptibility to pelargonidin
CTD
PMID:31181187
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:18274639
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
pelargonidin results in increased expression of NQO1 mRNA; pelargonidin results in increased expression of NQO1 protein
CTD
PMID:31181187
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
CTD
PMID:21341175
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
pelargonidin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]
CTD
PMID:18274639 PMID:30753810
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tlr4
toll-like receptor 4
multiple interactions
ISO
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein]
CTD
PMID:30753810
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
multiple interactions
ISO
pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
CTD
PMID:18720166 PMID:30753810
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Txnrd1
thioredoxin reductase 1
decreases activity
EXP
pelargonidin results in decreased activity of TXNRD1 protein modified form
CTD
PMID:16618767
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 mRNA]; pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein]
CTD
PMID:30753810
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Car1
carbonic anhydrase 1
decreases activity
ISO
pelargonidin-3-glucoside results in decreased activity of CA1 protein
CTD
PMID:28445001
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
pelargonidin-3-glucoside results in decreased activity of CA2 protein
CTD
PMID:28445001
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car1
carbonic anhydrase 1
decreases activity
ISO
pelargonidin-3-glucoside results in decreased activity of CA1 protein
CTD
PMID:28445001
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
pelargonidin-3-glucoside results in decreased activity of CA2 protein
CTD
PMID:28445001
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Pdgfa
platelet derived growth factor subunit A
multiple interactions
ISO
peonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]
CTD
PMID:16921400
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
G
Pdgfb
platelet derived growth factor subunit B
multiple interactions
ISO
peonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]
CTD
PMID:16921400
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Pdgfa
platelet derived growth factor subunit A
multiple interactions
ISO
peonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]
CTD
PMID:16921400
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
G
Pdgfb
platelet derived growth factor subunit B
multiple interactions
ISO
peonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]
CTD
PMID:16921400
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Aqp3
aquaporin 3 (Gill blood group)
multiple interactions
ISO
[malvidin-3-glucoside co-treated with petunidin-3-glucoside] results in increased expression of AQP3 mRNA
CTD
PMID:33294640
NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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