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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-phenoxybenzoic acid
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Accession:CHEBI:72631 term browser browse the term
Definition:A phenoxybenzoic acid in which the phenoxy group is meta to the carboxy group. It is a metabolite of pyrethroid insecticides.
Synonyms:related_synonym: 3-PhOC6H4CO2H;   3-PhOC6H4COOH;   3-carboxybiphenyl ether;   3-carboxydiphenyl ether;   Formula=C13H10O3;   InChI=1S/C13H10O3/c14-13(15)10-5-4-8-12(9-10)16-11-6-2-1-3-7-11/h1-9H,(H,14,15);   InChIKey=NXTDJHZGHOFSQG-UHFFFAOYSA-N;   SMILES=OC(=O)c1cccc(Oc2ccccc2)c1;   diphenyl ether 3-carboxylic acid;   m-carboxydiphenyl ether;   m-phenoxybenzoic acid;   meta-phenoxybenzoic acid
 xref: CAS:3739-38-6;   HMDB:HMDB0041807
 xref_mesh: MESH:C017618
 xref: PMID:19081088;   PMID:19458958;   PMID:19853000;   PMID:21238715;   PMID:21571933;   PMID:21717113;   PMID:23146693;   PMID:23226289;   PMID:6114835;   PMID:6114836;   PMID:8409231;   Reaxys:2105574


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3-phenoxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions
ISO 3-phenoxybenzoic acid results in decreased activity of AR protein
[Dihydrotestosterone co-treated with 3-phenoxybenzoic acid] results in decreased expression of AR mRNA
CTD PMID:16857237, PMID:20410157 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO 3-phenoxybenzoic acid binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP 3-phenoxybenzoic acid results in increased expression of CYP4A1 mRNA CTD PMID:32040184 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Esr1 estrogen receptor 1 decreases activity
multiple interactions
EXP
ISO
3-phenoxybenzoic acid results in decreased activity of ESR1 protein
3-phenoxybenzoic acid inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]
CTD PMID:20410157, PMID:24388911 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects binding ISO 3-phenoxybenzoic acid binds to GSTP1 protein CTD PMID:32278787 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 3-phenoxybenzoic acid inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP 3-phenoxybenzoic acid inhibits the reaction [Hydrocortisone results in increased expression of PCK1 mRNA] CTD PMID:26647222 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO 3-phenoxybenzoic acid binds to RORA protein CTD PMID:32278787 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Rorc RAR-related orphan receptor C affects binding ISO 3-phenoxybenzoic acid binds to RORC protein CTD PMID:32278787 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO 3-phenoxybenzoic acid binds to RXRG protein CTD PMID:32278787 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 3-phenoxybenzoic acid results in increased expression of TFF1 mRNA CTD PMID:20397420 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO 3-phenoxybenzoic acid inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:26647222 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO [Insecticides results in increased abundance of 3-phenoxybenzoic acid] which results in increased expression of TSHB protein CTD PMID:31284115 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Vdr vitamin D receptor affects binding ISO 3-phenoxybenzoic acid binds to VDR protein CTD PMID:32278787 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            xenobiotic metabolite 14043
              human xenobiotic metabolite 13294
                3-phenoxybenzoic acid 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            phenoxybenzoic acid 14
                                              3-phenoxybenzoic acid 14
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