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ONTOLOGY REPORT - ANNOTATIONS


Term:WR-1065
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Accession:CHEBI:72583 term browser browse the term
Definition:An alkanethiol that is the N-3-aminopropyl derivative of cysteamine. Used as the S-phosphorylated prodrug, amifostine, for cytoprotection in cancer chemotherapy and radiotherapy.
Synonyms:exact_synonym: 2-[(3-aminopropyl)amino]ethanethiol
 related_synonym: Formula=C5H14N2S;   InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2;   InChIKey=YHPLKWQJMAYFCN-UHFFFAOYSA-N;   SMILES=NCCCNCCS
 alt_id: CHEBI:10031
 xref: CAS:31098-42-7;   KEGG:C07651
 xref_mesh: MESH:C020174
 xref: PMID:10190490;   PMID:10755379;   PMID:10825757;   PMID:1311732;   PMID:14716750;   PMID:15557777;   PMID:18206143;   PMID:19016138;   PMID:1908337;   PMID:1968940;   PMID:20095849;   PMID:2982751;   PMID:2988568;   PMID:3340731;   PMID:6480445;   PMID:7513807;   PMID:8012934;   PMID:8434118;   Patent:WO2007123868;   Reaxys:2069586


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WR-1065 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:6480464
G Myb MYB proto-oncogene, transcription factor JBrowse link 1 16,658,178 16,690,135 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6480464
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      chemical role 19258
        antioxidant 14222
          WR-1065 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    main group molecular entity 19664
                      s-block molecular entity 19406
                        hydrogen molecular entity 19397
                          hydrides 18386
                            inorganic hydride 17221
                              pnictogen hydride 17184
                                nitrogen hydride 17020
                                  azane 16716
                                    ammonia 16715
                                      organic amino compound 16714
                                        primary amino compound 7861
                                          primary amine 5659
                                            primary aliphatic amine 136
                                              ethylamine 45
                                                cysteamine 44
                                                  WR-1065 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.