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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:WR-1065
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Accession:CHEBI:72583 term browser browse the term
Definition:An alkanethiol that is the N-3-aminopropyl derivative of cysteamine. Used as the S-phosphorylated prodrug, amifostine, for cytoprotection in cancer chemotherapy and radiotherapy.
Synonyms:exact_synonym: 2-[(3-aminopropyl)amino]ethanethiol
 related_synonym: Formula=C5H14N2S;   InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2;   InChIKey=YHPLKWQJMAYFCN-UHFFFAOYSA-N;   SMILES=NCCCNCCS
 alt_id: CHEBI:10031
 xref: CAS:31098-42-7;   KEGG:C07651
 xref_mesh: MESH:C020174
 xref: PMID:10190490;   PMID:10755379;   PMID:10825757;   PMID:1311732;   PMID:14716750;   PMID:15557777;   PMID:18206143;   PMID:19016138;   PMID:1908337;   PMID:1968940;   PMID:20095849;   PMID:2982751;   PMID:2988568;   PMID:3340731;   PMID:6480445;   PMID:7513807;   PMID:8012934;   PMID:8434118;   Patent:WO2007123868;   Reaxys:2069586


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WR-1065 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases expression ISO WR 1065 results in increased expression of CAT protein CTD PMID:17388698 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO WR 1065 results in increased expression of CCL5 mRNA CTD PMID:12007958 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO WR 1065 results in decreased expression of GSTP1 mRNA CTD PMID:12007958 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO WR 1065 results in increased expression of IL2RA mRNA CTD PMID:12007958 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO WR 1065 results in increased expression of MYB mRNA CTD PMID:12007958 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO WR 1065 results in decreased expression of MYC mRNA CTD PMID:12007958 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO WR 1065 results in increased activity of [NFKB1 protein binds to RELA protein]; WR 1065 results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188 PMID:11917294 PMID:12007958 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO WR 1065 results in increased activity of [NFKB1 protein binds to RELA protein]; WR 1065 results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188 PMID:11917294 PMID:12007958 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
increases activity
multiple interactions
ISO WR 1065 results in increased expression of SOD2 mRNA; WR 1065 results in increased expression of SOD2 protein
WR 1065 results in increased activity of SOD2
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2]
helenalin inhibits the reaction [WR 1065 results in increased expression of SOD2 protein]; WR 1065 results in increased expression of and results in increased activity of SOD2 protein
CTD PMID:11390188 PMID:11917294 PMID:12007958 PMID:16540396 PMID:17388698 PMID:21945096 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19781
    role 19726
      chemical role 19270
        antioxidant 14275
          WR-1065 11
Path 2
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  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    main group molecular entity 19669
                      s-block molecular entity 19434
                        hydrogen molecular entity 19429
                          hydrides 18757
                            inorganic hydride 17455
                              pnictogen hydride 17431
                                nitrogen hydride 17278
                                  azane 17010
                                    ammonia 17009
                                      organic amino compound 17008
                                        primary amino compound 7949
                                          primary amine 5720
                                            primary aliphatic amine 139
                                              ethylamine 45
                                                cysteamine 44
                                                  WR-1065 11
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