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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:WR-1065
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Accession:CHEBI:72583 term browser browse the term
Definition:An alkanethiol that is the N-3-aminopropyl derivative of cysteamine. Used as the S-phosphorylated prodrug, amifostine, for cytoprotection in cancer chemotherapy and radiotherapy.
Synonyms:exact_synonym: 2-[(3-aminopropyl)amino]ethanethiol
 related_synonym: Formula=C5H14N2S;   InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2;   InChIKey=YHPLKWQJMAYFCN-UHFFFAOYSA-N;   SMILES=NCCCNCCS
 alt_id: CHEBI:10031
 xref: CAS:31098-42-7;   KEGG:C07651
 xref_mesh: MESH:C020174
 xref: PMID:10190490;   PMID:10755379;   PMID:10825757;   PMID:1311732;   PMID:14716750;   PMID:15557777;   PMID:18206143;   PMID:19016138;   PMID:1908337;   PMID:1968940;   PMID:20095849;   PMID:2982751;   PMID:2988568;   PMID:3340731;   PMID:6480445;   PMID:7513807;   PMID:8012934;   PMID:8434118;   Patent:WO2007123868;   Reaxys:2069586



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WR-1065 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases expression ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CAT protein CTD PMID:17388698 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CCL5 mRNA CTD PMID:12007958 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of GSTP1 mRNA CTD PMID:12007958 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of IL2RA mRNA CTD PMID:12007958 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of MYB mRNA CTD PMID:12007958 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of MYC mRNA CTD PMID:12007958 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188 PMID:11917294 PMID:12007958 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188 PMID:11917294 PMID:12007958 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
increases activity
multiple interactions
ISO N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 mRNA; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]
helenalin inhibits the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of and results in increased activity of SOD2 protein
CTD PMID:11390188 PMID:11917294 PMID:12007958 PMID:16540396 PMID:17388698 More... NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      chemical role 19530
        antioxidant 14499
          WR-1065 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    main group molecular entity 19948
                      s-block molecular entity 19735
                        hydrogen molecular entity 19727
                          hydrides 19093
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17767
                                  azane 17517
                                    ammonia 17516
                                      organic amino compound 17516
                                        primary amino compound 8271
                                          primary amine 5836
                                            primary aliphatic amine 145
                                              ethylamine 45
                                                cysteamine 44
                                                  WR-1065 11
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