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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triazene derivative
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Accession:CHEBI:72573 term browser browse the term
Definition:A nitrogen molecular entity resulting from the formal substitution of one or more of the hydrogens of triazene.
Synonyms:related_synonym: Formula=N3R3;   SMILES=[*]N=NN([*])[*];   triazene derivatives;   triazenes

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dacarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance		 ISO APEX1 protein mutant form results in increased susceptibility to Dacarbazine
APEX1 protein results in decreased susceptibility to Dacarbazine		 CTD PMID:16373707 PMID:19470598 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Dacarbazine results in increased expression of BIRC5 protein CTD PMID:15577328 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17410615 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA1 protein] results in increased expression of CD38 protein; [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD38 protein; Dacarbazine promotes the reaction [IFNA1 protein results in increased expression of CD38 protein] CTD PMID:11583285 PMID:14669796 PMID:16078447 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672 		JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD69 protein; [Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]; Dacarbazine affects the reaction [IFNA2 protein results in increased expression of CD69 protein] CTD PMID:14669796 PMID:17973783 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084 		JBrowse link
G Clu clusterin affects response to substance ISO CLU protein affects the susceptibility to Dacarbazine CTD PMID:15955107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions		 ISO CYP1A1 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A1 protein results in increased metabolism of Dacarbazine metabolite]		 CTD PMID:11751525 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO CYP1A2 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A2 protein results in increased metabolism of Dacarbazine metabolite]		 CTD PMID:11751525 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Dacarbazine CTD PMID:15743794 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IFNG mRNA CTD PMID:12202904 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IL6 mRNA CTD PMID:12202904 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Irf1 interferon regulatory factor 1 increases expression
multiple interactions		 ISO Dacarbazine results in increased expression of IRF1 mRNA
Isotretinoin promotes the reaction [Dacarbazine results in increased expression of IRF1 mRNA]		 CTD PMID:17973783 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases response to substance ISO MAP3K1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases response to substance ISO MAPK1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases response to substance ISO MAPK3 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Dacarbazine CTD PMID:12787138 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity
decreases response to substance
increases response to substance
affects response to substance
decreases expression		 ISO Dacarbazine results in decreased activity of MGMT protein
MGMT protein results in decreased susceptibility to Dacarbazine
MGMT gene mutant form results in increased susceptibility to Dacarbazine
MGMT protein affects the susceptibility to Dacarbazine
Dacarbazine results in decreased expression of MGMT protein		 CTD PMID:10751609 PMID:11023546 PMID:12170182 PMID:12494480 PMID:14562026 PMID:15010317 PMID:15870882 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases response to substance ISO SLC2A1 protein results in decreased susceptibility to Dacarbazine CTD PMID:17520257 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of TNF mRNA CTD PMID:12202904 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
increases expression
decreases response to substance		 ISO Dacarbazine results in increased secretion of VEGFA protein
Dacarbazine results in increased expression of VEGFA mRNA; Dacarbazine results in increased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to Dacarbazine		 CTD PMID:12939465 PMID:15026559 PMID:15123733 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
diminazene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases activity ISO Diminazene results in increased activity of ACE2 protein CTD PMID:21859683 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016 		JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 decreases activity ISO
EXP		 Diminazene results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365 		JBrowse link
temozolomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance ISO ABCC2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects response to substance ISO ABCG5 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Agr3 anterior gradient 3, protein disulphide isomerase family member affects response to substance ISO AGR3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:55,371,738...55,424,233
Ensembl chr 6:55,371,738...55,424,674 		JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein mutant form results in decreased susceptibility to temozolomide; AGT protein results in decreased susceptibility to temozolomide CTD PMID:11034089 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B affects response to substance ISO AKR1B1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of and results in decreased activity of CDC25C protein]; AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of and results in decreased activity of CDK1 protein]; AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of CHEK2 protein] CTD PMID:15930307 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects response to substance ISO ALDH1A3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882 		JBrowse link
G Ank2 ankyrin 2 affects response to substance ISO ANK2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 affects response to substance ISO ANKRD1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548 		JBrowse link
G Ap1s2 adaptor related protein complex 1 subunit sigma 2 affects response to substance ISO AP1S2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr  X:32,329,883...32,376,301
Ensembl chr  X:32,329,598...32,355,307 		JBrowse link
G Apc APC regulator of WNT signaling pathway affects response to substance ISO APC mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases response to substance
increases response to substance		 ISO APEX1 protein results in decreased susceptibility to temozolomide
APEX1 protein mutant form results in increased susceptibility to temozolomide		 CTD PMID:12231548 PMID:16243814 PMID:19470598 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Arf1 ADP-ribosylation factor 1 affects response to substance ISO ARF1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029 		JBrowse link
G Arrdc2 arrestin domain containing 2 affects response to substance ISO ARRDC2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr16:20,352,480...20,356,612
Ensembl chr16:20,352,480...20,356,612 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation		 ISO [temozolomide co-treated with resveratrol] results in increased phosphorylation of ATM protein
temozolomide results in increased phosphorylation of ATM protein		 CTD PMID:23522185 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to temozolomide CTD PMID:21730979 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G B4galnt2 beta-1,4-N-acetyl-galactosaminyl transferase 2 multiple interactions
increases mutagenesis		 ISO MSH2 gene mutant form promotes the reaction [temozolomide results in increased mutagenesis of B4GALNT2] CTD PMID:20025921 NCBI chr10:83,677,768...83,701,487 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Temozolomide analog results in increased expression of BAX protein; Temozolomide results in increased expression of BAX mRNA; Temozolomide results in increased expression of BAX protein
[Verapamil co-treated with Temozolomide] results in increased expression of BAX mRNA; Temozolomide promotes the reaction [Verapamil results in increased expression of BAX protein]
[temozolomide co-treated with O(6)-benzylguanine] results in increased expression of BAX protein; TRP53 protein affects the reaction [[temozolomide co-treated with O(6)-benzylguanine] results in increased expression of BAX protein]		 CTD PMID:19363609 PMID:20980775 PMID:30003979 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of BCL2 protein; TRP53 protein mutant form inhibits the reaction [[temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of BCL2 protein]
[Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 mRNA; [Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 protein; Resveratrol promotes the reaction [Temozolomide results in decreased expression of BCL2 protein]
temozolomide analog results in decreased expression of BCL2 protein; temozolomide results in decreased expression of BCL2 protein		 CTD PMID:19363609 PMID:20980775 PMID:22530672 PMID:30003979 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO MGMT protein affects the reaction [BCL2L1 protein affects the susceptibility to temozolomide] CTD PMID:16405512 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO BCL2L11 mutant form inhibits the reaction [temozolomide results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [temozolomide results in increased expression of BCL2L11 mRNA]
temozolomide results in increased expression of BCL2L11 mRNA; temozolomide results in increased expression of BCL2L11 protein		 CTD PMID:26418950 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO temozolomide results in increased expression of BECN1 protein
Thalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein]		 CTD PMID:19567134 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO temozolomide results in decreased expression of BIRC5 protein
XAF1 protein promotes the reaction [temozolomide results in decreased expression of BIRC5 protein]		 CTD PMID:28122345 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bmp5 bone morphogenetic protein 5 affects response to substance ISO BMP5 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases response to substance ISO BRCA2 protein results in decreased susceptibility to temozolomide CTD PMID:20028873 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748 		JBrowse link
G Cadm1 cell adhesion molecule 1 affects response to substance ISO CADM1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 8:51,858,906...52,200,591
Ensembl chr 8:52,127,399...52,189,722 		JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions		 ISO temozolomide results in increased expression of CASP12 protein
[temozolomide co-treated with Quercetin] results in increased expression of CASP12 protein		 CTD PMID:24126416 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression		 ISO [Pyrimethamine co-treated with Temozolomide] results in increased cleavage of CASP3 protein; [Quercetin co-treated with Temozolomide] results in increased activity of CASP3 protein; [Temozolomide co-treated with Quercetin] results in increased activity of CASP3 protein
temozolomide analog results in increased activity of CASP3 protein; temozolomide results in increased activity of CASP3 protein
temozolomide results in increased cleavage of CASP3 protein
temozolomide results in increased expression of CASP3		 CTD PMID:19363609 PMID:19435820 PMID:20654599 PMID:22231932 PMID:24126416 PMID:26418950 PMID:26911376 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity ISO temozolomide results in increased activity of CASP7 protein CTD PMID:26911376 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein
temozolomide results in increased cleavage of CASP8 protein		 CTD PMID:21514314 PMID:26418950 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO [Temozolomide co-treated with Quercetin] results in increased activity of CASP9 protein; BCL2L11 mutant form inhibits the reaction [Temozolomide results in increased cleavage of CASP9 protein]
temozolomide results in increased cleavage of CASP9 protein		 CTD PMID:24126416 PMID:26418950 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects response to substance
decreases expression
affects activity		 ISO CCL2 mRNA affects the susceptibility to temozolomide
temozolomide results in decreased expression of CCL2 protein
temozolomide affects the activity of CCL2 protein		 CTD PMID:16365179 PMID:17522861 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccn4 cellular communication network factor 4 affects response to substance ISO CCN4 mRNA affects the susceptibility to Temozolomide CTD PMID:16365179 NCBI chr 7:107,695,227...107,723,759
Ensembl chr 7:107,695,215...107,723,772 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [resveratrol co-treated with temozolomide] results in increased expression of CCNB1 protein CTD PMID:23522185 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 decreases phosphorylation
multiple interactions
affects response to substance		 ISO temozolomide results in decreased phosphorylation of CCND1 protein
[temozolomide co-treated with resveratrol] results in decreased expression of CCND1 protein
CCND1 mRNA affects the susceptibility to temozolomide		 CTD PMID:15930307 PMID:16365179 PMID:23522185 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) affects response to substance ISO CD44 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658 		JBrowse link
G Cd59 CD59 molecule decreases lipidation EXP temozolomide results in decreased lipidation of CD59 protein CTD PMID:27931811 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of and results in decreased activity of CDC25C protein]; temozolomide results in increased phosphorylation of and results in decreased activity of CDC25C protein CTD PMID:15930307 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdh13 cadherin 13 affects response to substance ISO CDH13 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
affects phosphorylation		 ISO [temozolomide co-treated with resveratrol] results in decreased phosphorylation of CDK1 protein; AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of and results in decreased activity of CDK1 protein]; temozolomide results in increased phosphorylation of and results in decreased activity of CDK1 protein
temozolomide affects the phosphorylation of CDK1 protein		 CTD PMID:15930307 PMID:23522185 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [temozolomide co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein; TRP53 protein affects the reaction [[temozolomide co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein]
[temozolomide co-treated with O(6)-benzylguanine] affects the localization of CDKN1A protein; [temozolomide co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein
temozolomide results in increased expression of CDKN1A protein		 CTD PMID:16193384 PMID:20980775 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of CDKN1B protein CTD PMID:20980775 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C affects response to substance ISO CDKN1C mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721 		JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 affects response to substance ISO CHD2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:134,757,934...134,873,053
Ensembl chr 1:134,757,934...134,871,167 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation
multiple interactions		 ISO temozolomide results in increased phosphorylation of CHEK1 protein; temozolomide results in increased phosphorylation of CHK1 protein
XAF1 protein promotes the reaction [temozolomide results in increased phosphorylation of CHK1 protein]		 CTD PMID:15930307 PMID:28122345 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation		 ISO [temozolomide co-treated with resveratrol] results in increased phosphorylation of CHEK2 protein; AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of CHEK2 protein] CTD PMID:15930307 PMID:23522185 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Col1a1 collagen type I alpha 1 chain affects response to substance ISO COL1A1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 affects response to substance
increases expression		 ISO COX4I1 protein affects the susceptibility to temozolomide
temozolomide results in increased expression of COX4I1 protein		 CTD PMID:20870728 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225 		JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 decreases expression ISO temozolomide results in decreased expression of COX4I2 protein CTD PMID:20870728 NCBI chr 3:148,234,546...148,245,424
Ensembl chr 3:148,234,193...148,245,416 		JBrowse link
G Csf2 colony stimulating factor 2 affects response to substance ISO CSF2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 affects response to substance ISO CSGALNACT1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 affects response to substance ISO CSRP3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects response to substance ISO CXCL1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects response to substance
decreases secretion		 ISO CXCL2 mRNA affects the susceptibility to temozolomide
temozolomide results in decreased secretion of CXCL2 protein		 CTD PMID:16365179 PMID:21509778 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects response to substance ISO CXCL1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Dct dopachrome tautomerase decreases response to substance ISO DCT protein results in decreased susceptibility to temozolomide CTD PMID:15897911 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494 		JBrowse link
G Def6 DEF6 guanine nucleotide exchange factor affects response to substance ISO DEF6 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr20:7,788,120...7,809,011
Ensembl chr20:7,788,084...7,809,560 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 affects response to substance ISO DHRS3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383 		JBrowse link
G Dhx37 DEAH-box helicase 37 affects response to substance ISO DHX37 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr12:36,594,058...36,614,165
Ensembl chr12:36,594,047...36,614,210 		JBrowse link
G Dmrtc2 DMRT-like family C2 affects response to substance ISO DMRTC2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:81,734,256...81,741,419
Ensembl chr 1:81,736,335...81,741,345 		JBrowse link
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B affects response to substance ISO DYRK1B mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:85,112,819...85,120,840
Ensembl chr 1:85,112,247...85,120,839 		JBrowse link
G Ednra endothelin receptor type A affects response to substance ISO EDNRA mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects response to substance ISO EIF4A2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr11:81,373,047...81,379,680
Ensembl chr11:81,373,048...81,379,871 		JBrowse link
G Elmo1 engulfment and cell motility 1 affects response to substance ISO ELMO1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr17:46,352,102...46,888,788
Ensembl chr17:46,353,330...46,794,845 		JBrowse link
G Etv1 ETS variant transcription factor 1 affects response to substance ISO ETV1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:58,467,215...58,558,640
Ensembl chr 6:58,467,254...58,558,631 		JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 affects response to substance ISO EXTL1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:152,573,755...152,588,956
Ensembl chr 5:152,573,758...152,589,719 		JBrowse link
G Fancc FA complementation group C affects response to substance ISO FANCC mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr17:826,512...955,703
Ensembl chr17:833,509...955,615 		JBrowse link
G Fancd2 FA complementation group D2 increases ubiquitination
affects localization		 ISO temozolomide results in increased ubiquitination of FANCD2 protein
temozolomide affects the localization of FANCD2 protein		 CTD PMID:17221219 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO pyrazolanthrone affects the reaction [temozolomide results in increased expression of FASLG mRNA]; SB 203580 affects the reaction [temozolomide results in increased expression of FASLG mRNA] CTD PMID:26418950 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fbxo32 F-box protein 32 affects response to substance ISO FBXO32 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [temozolomide co-treated with Thalidomide] results in decreased expression of FGF2 protein CTD PMID:16327979 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fhl2 four and a half LIM domains 2 affects response to substance ISO FHL2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093 		JBrowse link
G Foxf2 forkhead box F2 affects response to substance ISO FOXF2 mRNA affects the susceptibility to Temozolomide CTD PMID:16365179 NCBI chr17:34,150,417...34,156,450 JBrowse link
G Fut8 fucosyltransferase 8 affects response to substance ISO FUT8 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects response to substance ISO GABRA2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302 		JBrowse link
G Galnt15 polypeptide N-acetylgalactosaminyltransferase 15 affects response to substance ISO GALNT15 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr16:8,127,599...8,178,101
Ensembl chr16:8,128,689...8,177,841 		JBrowse link
G Garnl3 GTPase activating Rap/RanGAP domain-like 3 affects response to substance ISO GARNL3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:12,034,131...12,176,591
Ensembl chr 3:12,034,413...12,155,098 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO resveratrol promotes the reaction [temozolomide results in increased expression of GFAP protein]; temozolomide promotes the reaction [resveratrol results in increased expression of GFAP protein] CTD PMID:22530672 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Glrb glycine receptor, beta affects response to substance ISO GLRB mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
decreases response to substance
increases phosphorylation		 ISO [Temozolomide co-treated with Resveratrol] results in increased phosphorylation of H2AX protein
H2AX protein results in decreased susceptibility to Temozolomide
Temozolomide results in increased phosphorylation of H2AX protein		 CTD PMID:21555580 PMID:23522185 PMID:26418950 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hhat hedgehog acyltransferase affects response to substance ISO HHAT mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr13:111,235,325...111,489,075
Ensembl chr13:111,236,466...111,474,411 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis
multiple interactions		 ISO temozolomide results in increased mutagenesis of HPRT1 gene
MGMT protein inhibits the reaction [temozolomide results in increased mutagenesis of HPRT1 gene]		 CTD PMID:17116724 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases response to substance
multiple interactions		 ISO HSPA1A mutant form results in increased susceptibility to temozolomide
HSPA1A mutant form results in increased susceptibility to [Quercetin co-treated with temozolomide]		 CTD PMID:24126416 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
increases response to substance		 ISO HSPB1 mutant form results in increased susceptibility to [Quercetin co-treated with temozolomide]
HSPB1 mutant form results in increased susceptibility to temozolomide		 CTD PMID:24126416 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Igf2 insulin-like growth factor 2 affects response to substance ISO IGF2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 affects response to substance ISO IL1R1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670 		JBrowse link
G Il24 interleukin 24 increases response to substance
multiple interactions		 ISO IL24 protein results in increased susceptibility to temozolomide
MGMT protein promotes the reaction [IL24 protein results in increased susceptibility to temozolomide]		 CTD PMID:19056673 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849 		JBrowse link
G Il6 interleukin 6 affects response to substance ISO IL6 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhba inhibin subunit beta A affects response to substance ISO INHBA mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496 		JBrowse link
G Ipo4 importin 4 affects response to substance ISO IPO4 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr15:34,304,425...34,314,552
Ensembl chr15:34,304,425...34,314,345 		JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 affects response to substance ISO KCNAB2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:169,570,327...169,658,875
Ensembl chr 5:169,572,517...169,658,875 		JBrowse link
G Krt8 keratin 8 affects response to substance ISO KRT8 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803 		JBrowse link
G Lbp lipopolysaccharide binding protein affects response to substance ISO LBP mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases response to substance ISO LIF mRNA results in increased susceptibility to temozolomide CTD PMID:16365179 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642 		JBrowse link
G Lins1 lines homolog 1 affects response to substance ISO LINS1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:127,599,647...127,625,583
Ensembl chr 1:127,604,197...127,625,577 		JBrowse link
G Lman1l lectin, mannose-binding, 1 like affects response to substance ISO LMAN1L mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 8:62,386,806...62,400,370
Ensembl chr 8:62,386,806...62,399,648 		JBrowse link
G Lmtk2 lemur tyrosine kinase 2 affects response to substance ISO LMTK2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr12:12,409,876...12,546,111
Ensembl chr12:12,409,876...12,546,111 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO temozolomide results in increased expression of MAP1LC3B protein
Thalidomide promotes the reaction [temozolomide results in increased expression of MAP1LC3B protein]		 CTD PMID:19567134 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Masp1 mannan-binding lectin serine peptidase 1 affects response to substance ISO MASP1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr11:80,736,424...80,806,278
Ensembl chr11:80,736,576...80,803,382 		JBrowse link
G Mecom MDS1 and EVI1 complex locus affects response to substance ISO EVI1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance
decreases activity
multiple interactions
affects response to substance		 ISO MGMT mRNA results in decreased susceptibility to temozolomide; MGMT protein results in decreased susceptibility to temozolomide; MGMT results in decreased susceptibility to temozolomide
temozolomide results in decreased activity of MGMT protein
[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide; [O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide; MGMT protein affects the reaction [BCL2L1 protein affects the susceptibility to temozolomide]; MGMT protein mutant form results in decreased susceptibility to [O(6)-(4-bromothenyl)guanine co-treated with temozolomide]; MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]; MGMT protein promotes the reaction [IL24 protein results in increased susceptibility to temozolomide]; MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]; O(6)-(4-bromothenyl)guanine inhibits the reaction [MGMT protein results in decreased susceptibility to temozolomide]
MGMT protein inhibits the reaction [temozolomide results in increased mutagenesis of HPRT1 gene]
MGMT promoter modified form affects the susceptibility to temozolomide; MGMT protein affects the susceptibility to temozolomide		 CTD PMID:9918549 PMID:10753191 PMID:12538819 PMID:14506174 PMID:15297393 PMID:15319033 PMID:15486188 PMID:15758010 PMID:15814657 PMID:15833865 PMID:15865885 PMID:16039682 PMID:16075413 PMID:16365179 PMID:16405512 PMID:16432170 PMID:17116724 PMID:18430789 PMID:19056673 PMID:20167086 PMID:20556481 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 affects response to substance ISO MGST2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281 		JBrowse link
G Mlh1 mutL homolog 1 affects response to substance
multiple interactions		 ISO MLH1 protein affects the susceptibility to temozolomide
[temozolomide co-treated with O(6)-benzylguanine] affects the expression of MLH1 protein		 CTD PMID:12967659 PMID:18430789 PMID:20980775 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Mlph melanophilin affects response to substance ISO MLPH mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 9:98,072,965...98,108,429
Ensembl chr 9:98,073,038...98,108,433 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO resveratrol inhibits the reaction [temozolomide results in decreased expression of MMP9 protein] CTD PMID:22530672 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase multiple interactions
decreases response to substance
increases response to substance		 ISO methoxyamine promotes the reaction [MPG protein results in increased susceptibility to temozolomide]; MPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]; MPG protein promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased susceptibility to temozolomide]; MPG protein promotes the reaction [veliparib results in increased susceptibility to temozolomide]; POLB protein inhibits the reaction [MPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]]
MPG affects the reaction [MSH2 results in decreased susceptibility to temozolomide]
MPG protein results in decreased susceptibility to temozolomide		 CTD PMID:15299078 PMID:16024643 PMID:16288039 PMID:20025921 PMID:21377995 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase affects response to substance ISO MPST mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425 		JBrowse link
G Msh2 mutS homolog 2 decreases response to substance
multiple interactions
affects response to substance		 ISO MSH2 results in decreased susceptibility to temozolomide
MPG affects the reaction [MSH2 results in decreased susceptibility to temozolomide]; MSH2 gene mutant form promotes the reaction [temozolomide results in increased mutagenesis of B4GALNT2]
[temozolomide co-treated with O(6)-benzylguanine] affects the expression of MSH2 protein
MSH2 protein affects the susceptibility to temozolomide		 CTD PMID:18430789 PMID:20025921 PMID:20980775 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Mt2A metallothionein 2A affects response to substance ISO MT2A mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO temozolomide results in decreased phosphorylation of MTOR protein
resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]; TSC1 protein affects the reaction [resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]]; TSC1 protein affects the reaction [temozolomide results in decreased phosphorylation of MTOR protein]		 CTD PMID:22530672 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Mturn maturin, neural progenitor differentiation regulator homolog affects response to substance ISO MTURN mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 4:84,854,341...84,875,300
Ensembl chr 4:84,854,386...84,871,757 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist affects response to substance ISO NBL1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:157,524,569...157,535,701
Ensembl chr 5:157,524,513...157,535,664 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 affects response to substance ISO NFAT5 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735 		JBrowse link
G Nfib nuclear factor I/B affects response to substance ISO NFIB mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727 		JBrowse link
G Nfix nuclear factor I X affects response to substance ISO NFIX mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases response to substance		 ISO temozolomide inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]
NFKBIA mRNA results in increased susceptibility to temozolomide		 CTD PMID:16365179 PMID:17638900 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nin ninein affects response to substance ISO NIN mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:92,423,412...92,527,776
Ensembl chr 6:92,433,381...92,527,711 		JBrowse link
G Nkd2 NKD inhibitor of WNT signaling pathway 2 affects response to substance ISO NKD2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:32,054,390...32,085,416
Ensembl chr 1:32,058,044...32,084,877 		JBrowse link
G Npas2 neuronal PAS domain protein 2 affects response to substance ISO NPAS2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880 		JBrowse link
G Npl N-acetylneuraminate pyruvate lyase affects response to substance ISO NPL mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr13:70,938,073...70,981,179
Ensembl chr13:70,938,082...70,980,913 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 affects response to substance ISO NR2F1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894 		JBrowse link
G P3h3 prolyl 3-hydroxylase 3 affects response to substance ISO P3H3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 4:157,359,331...157,375,186
Ensembl chr 4:157,359,332...157,372,861 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases response to substance		 ISO PARP1 protein affects the susceptibility to [temozolomide co-treated with veliparib]
PARP1 protein results in decreased susceptibility to temozolomide		 CTD PMID:19825992 PMID:21555580 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcdhb2 protocadherin beta 2 affects response to substance ISO PCDHB2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr18:30,375,798...30,378,194
Ensembl chr18:30,375,798...30,378,194 		JBrowse link
G Pde5a phosphodiesterase 5A affects response to substance ISO PDE5A mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576 		JBrowse link
G Pgm2 phosphoglucomutase 2 affects response to substance ISO PGM2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr14:45,829,440...45,863,883
Ensembl chr14:45,829,446...45,863,877 		JBrowse link
G Phc2 polyhomeotic homolog 2 affects response to substance ISO PHC2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:146,832,552...146,931,444
Ensembl chr 5:146,882,756...146,931,444 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 affects response to substance ISO PHLDA1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions EXP temozolomide results in increased mutagenesis of and results in decreased activity of PIGA protein CTD PMID:27931811 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 affects response to substance ISO PIK3C3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta affects response to substance ISO PIK3CD mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028 		JBrowse link
G Pitpnc1 phosphatidylinositol transfer protein, cytoplasmic 1 affects response to substance ISO PITPNC1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:95,429,879...95,697,734 JBrowse link
G Pkp3 plakophilin 3 affects response to substance ISO PKP3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:213,884,795...213,897,783
Ensembl chr 1:213,886,775...213,897,783 		JBrowse link
G Plekhg5 pleckstrin homology and RhoGEF domain containing G5 affects response to substance ISO PLEKHG5 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:169,244,778...169,288,310
Ensembl chr 5:169,244,778...169,288,309 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO TP53 protein promotes the reaction [temozolomide results in increased expression of PMAIP1 mRNA] CTD PMID:17216584 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component multiple interactions ISO [temozolomide co-treated with O(6)-benzylguanine] affects the expression of PMS1 protein CTD PMID:20980775 NCBI chr 9:53,120,656...53,206,520
Ensembl chr 9:53,120,656...53,206,516 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component multiple interactions
affects response to substance		 ISO [temozolomide co-treated with O(6)-benzylguanine] affects the expression of PMS2 protein
PMS2 protein affects the susceptibility to temozolomide		 CTD PMID:12967659 PMID:20980775 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Polb DNA polymerase beta decreases response to substance
multiple interactions		 ISO POLB protein results in decreased susceptibility to temozolomide
POLB protein inhibits the reaction [MPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]]		 CTD PMID:16024643 PMID:21377995 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit affects response to substance ISO POLG2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:94,968,836...94,979,259
Ensembl chr10:94,968,836...94,979,259 		JBrowse link
G Popdc3 popeye domain containing 3 affects response to substance ISO POPDC3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr20:50,394,617...50,422,551
Ensembl chr20:50,394,650...50,422,560 		JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 affects response to substance ISO PREX1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:163,329,580...163,477,822
Ensembl chr 3:163,329,975...163,477,715 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 affects response to substance ISO PRKAA2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569 		JBrowse link
G Prl prolactin decreases secretion EXP temozolomide results in decreased secretion of PRL protein CTD PMID:20469984 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Prrx2 paired related homeobox 2 affects response to substance ISO PRRX2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:9,681,871...9,718,051
Ensembl chr 3:9,681,871...9,718,051 		JBrowse link
G Prss12 serine protease 12 affects response to substance ISO PRSS12 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:227,657,983...227,717,884
Ensembl chr 2:227,657,983...227,717,884 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO temozolomide results in decreased expression of PTGS2 mRNA
temozolomide inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]		 CTD PMID:17638900 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Qpct glutaminyl-peptide cyclotransferase affects response to substance ISO QPCT mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:1,657,110...1,689,575
Ensembl chr 6:1,657,331...1,689,559 		JBrowse link
G Rab27b RAB27B, member RAS oncogene family affects response to substance ISO RAB27B mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr18:68,486,006...68,644,595
Ensembl chr18:68,488,942...68,551,558 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [temozolomide co-treated with resveratrol] results in increased phosphorylation of RB1 protein CTD PMID:23522185 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbm19 RNA binding motif protein 19 affects response to substance ISO RBM19 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr12:41,907,978...41,993,969
Ensembl chr12:41,907,740...41,993,957 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO temozolomide results in decreased activity of RELA protein CTD PMID:17638900 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rgcc regulator of cell cycle affects response to substance ISO RGCC mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695 		JBrowse link
G Rgp1 RGP1 homolog, RAB6A GEF complex partner 1 affects response to substance ISO RGP1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:59,080,290...59,088,777
Ensembl chr 5:59,080,765...59,088,523 		JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 affects response to substance ISO RHOBTB3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:2,627,655...2,683,305
Ensembl chr 2:2,627,393...2,683,116 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 affects response to substance ISO SAT1 mRNA affects the susceptibility to Temozolomide CTD PMID:16365179 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765 		JBrowse link
G Scamp5 secretory carrier membrane protein 5 affects response to substance ISO SCAMP5 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 8:62,221,820...62,266,269
Ensembl chr 8:62,220,892...62,248,017 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 affects response to substance ISO SCN8A mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114 		JBrowse link
G Sdc1 syndecan 1 affects response to substance ISO SDC1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016 		JBrowse link
G Sema3a semaphorin 3A affects response to substance ISO SEMA3A mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 4:18,170,375...18,545,190
Ensembl chr 4:18,178,656...18,396,035 		JBrowse link
G Serpinb1a serpin family B member 1A affects response to substance ISO SERPINB1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495 		JBrowse link
G Sf1 splicing factor 1 affects response to substance ISO SF1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:221,735,512...221,749,216
Ensembl chr 1:221,735,517...221,749,086 		JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) affects response to substance ISO SLC14A1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 affects response to substance ISO SLC15A2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 affects response to substance ISO SLC22A5 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor affects response to substance ISO SLPI mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
affects response to substance		 ISO temozolomide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]
temozolomide results in decreased expression of SOD2 mRNA
SOD2 mRNA affects the susceptibility to temozolomide		 CTD PMID:16365179 PMID:17638900 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sox9 SRY-box transcription factor 9 affects response to substance ISO SOX9 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Temozolomide promotes the reaction [TP53 protein binds to SP1 protein] CTD PMID:29164620 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Sparc secreted protein acidic and cysteine rich affects response to substance ISO SPARC mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185 		JBrowse link
G Spen spen family transcriptional repressor affects response to substance ISO SPEN mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:160,015,573...160,070,915
Ensembl chr 5:160,015,454...160,070,965 		JBrowse link
G Sqle squalene epoxidase affects response to substance ISO SQLE mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732 		JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 affects response to substance ISO ST3GAL1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:107,895,045...107,963,158
Ensembl chr 7:107,895,045...107,963,142 		JBrowse link
G Stc1 stanniocalcin 1 affects response to substance ISO STC1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162 		JBrowse link
G Stxbp6 syntaxin binding protein 6 affects response to substance ISO STXBP6 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 6:65,086,483...65,319,527
Ensembl chr 6:65,089,318...65,319,527 		JBrowse link
G Synpo2 synaptopodin 2 affects response to substance ISO SYNPO2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:227,255,243...227,411,924
Ensembl chr 2:227,255,902...227,411,964 		JBrowse link
G Tagln transgelin affects response to substance ISO TAGLN mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357 		JBrowse link
G Tbx3 T-box transcription factor 3 affects response to substance ISO TBX3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526 		JBrowse link
G Tcim transcriptional and immune response regulator increases response to substance ISO TCIM mRNA results in increased susceptibility to temozolomide CTD PMID:16365179 NCBI chr16:72,401,526...72,403,180
Ensembl chr16:72,401,887...72,403,179 		JBrowse link
G Tdrp testis development related protein affects response to substance ISO TDRP mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr16:80,729,342...80,755,397
Ensembl chr16:80,729,400...80,755,415 		JBrowse link
G Tert telomerase reverse transcriptase decreases response to substance
multiple interactions		 ISO TERT protein mutant form results in decreased susceptibility to temozolomide
3-aminobenzamide inhibits the reaction [TERT protein mutant form results in decreased susceptibility to temozolomide]		 CTD PMID:12488552 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476 		JBrowse link
G Tfap2c transcription factor AP-2 gamma affects response to substance ISO TFAP2C mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194 		JBrowse link
G Tfdp1 transcription factor Dp-1 affects response to substance ISO TFDP1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr16:81,088,642...81,127,244
Ensembl chr16:81,089,292...81,127,257 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 affects response to substance ISO TFPI2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067 		JBrowse link
G Thbd thrombomodulin affects response to substance ISO THBD mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325 		JBrowse link
G Tmem158 transmembrane protein 158 affects response to substance ISO TMEM158 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 8:132,344,710...132,345,708
Ensembl chr 8:132,344,710...132,345,708 		JBrowse link
G Tmem19 transmembrane protein 19 affects response to substance ISO TMEM19 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 7:58,316,583...58,343,761
Ensembl chr 7:58,316,514...58,343,145 		JBrowse link
G Tmprss15 transmembrane serine protease 15 affects response to substance ISO TMPRSS15 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr11:17,561,591...17,684,903
Ensembl chr11:17,561,596...17,684,903 		JBrowse link
G Tnc tenascin C affects response to substance ISO TNC mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO temozolomide inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; temozolomide inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; temozolomide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; temozolomide inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] CTD PMID:17638900 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases response to substance ISO TNFAIP3 mRNA results in increased susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807 		JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 affects response to substance ISO TNFRSF19 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr15:41,249,820...41,316,203
Ensembl chr15:41,246,308...41,338,284 		JBrowse link
G Tnfsf10 TNF superfamily member 10 affects response to substance ISO TNFSF10 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
decreases response to substance
increases expression		 ISO [Temozolomide co-treated with O(6)-benzylguanine] results in increased expression of TP53 protein; Temozolomide promotes the reaction [TP53 protein binds to SP1 protein]; TP53 protein promotes the reaction [Temozolomide results in increased expression of PMAIP1 mRNA]; TP53 protein results in increased susceptibility to [Temozolomide co-treated with O(6)-benzylguanine]
TRP53 protein affects the reaction [[temozolomide co-treated with O(6)-benzylguanine] results in increased expression of BAX protein]; TRP53 protein affects the reaction [[temozolomide co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein]; TRP53 protein mutant form inhibits the reaction [[temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of BCL2 protein]; TRP53 protein results in increased susceptibility to [temozolomide co-treated with O(6)-benzylguanine]
TP53 protein results in increased susceptibility to temozolomide
TP53 protein results in decreased susceptibility to temozolomide
temozolomide results in increased expression of TP53 protein		 CTD PMID:16193384 PMID:16405512 PMID:17216584 PMID:20980775 PMID:29164620 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tpd52l1 TPD52 like 1 affects response to substance ISO TPD52L1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553 		JBrowse link
G Trim50 tripartite motif-containing 50 affects response to substance ISO TRIM50 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr12:24,348,426...24,365,467
Ensembl chr12:24,348,321...24,365,324 		JBrowse link
G Tsc1 TSC complex subunit 1 multiple interactions ISO TSC1 protein affects the reaction [resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]]; TSC1 protein affects the reaction [temozolomide results in decreased phosphorylation of MTOR protein] CTD PMID:22530672 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial affects response to substance ISO TUFM mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189 		JBrowse link
G Tulp3 TUB like protein 3 affects response to substance ISO TULP3 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 4:161,636,084...161,677,807
Ensembl chr 4:161,637,892...161,658,519 		JBrowse link
G Vamp4 vesicle-associated membrane protein 4 affects response to substance ISO VAMP4 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr13:80,460,699...80,483,597
Ensembl chr13:80,460,694...80,483,600 		JBrowse link
G Vat1l vesicle amine transport 1-like affects response to substance ISO VAT1L mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr19:46,525,895...46,693,838
Ensembl chr19:46,525,919...46,693,838 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [temozolomide co-treated with Thalidomide] results in decreased expression of VEGFA protein CTD PMID:16327979 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vldlr very low density lipoprotein receptor affects response to substance ISO VLDLR mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205 		JBrowse link
G Wasf2 WASP family member 2 affects response to substance ISO WASF2 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 5:151,319,382...151,385,051
Ensembl chr 5:151,343,493...151,381,238 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions
increases phosphorylation		 ISO resveratrol inhibits the reaction [temozolomide results in increased phosphorylation of WEE1 protein] CTD PMID:23522185 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361 		JBrowse link
G Wfdc1 WAP four-disulfide core domain 1 affects response to substance ISO WFDC1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr19:52,313,771...52,332,721
Ensembl chr19:52,313,795...52,332,697 		JBrowse link
G Wnt5a Wnt family member 5A affects response to substance ISO WNT5A mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860 		JBrowse link
G Xaf1 XIAP associated factor 1 increases response to substance
increases expression
multiple interactions		 ISO XAF1 protein results in increased susceptibility to temozolomide
temozolomide results in increased expression of XAF1 protein
XAF1 protein promotes the reaction [temozolomide results in decreased expression of BIRC5 protein]; XAF1 protein promotes the reaction [temozolomide results in decreased expression of XIAP protein]; XAF1 protein promotes the reaction [temozolomide results in increased phosphorylation of CHK1 protein]		 CTD PMID:28122345 NCBI chr10:58,860,647...58,872,782
Ensembl chr10:58,860,940...58,873,674 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression		 ISO temozolomide inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; XAF1 protein promotes the reaction [temozolomide results in decreased expression of XIAP protein]
temozolomide results in decreased expression of XIAP mRNA; temozolomide results in decreased expression of XIAP protein		 CTD PMID:17638900 PMID:28122345 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a multiple interactions ISO temozolomide promotes the reaction [resveratrol results in decreased expression of ZBTB7A protein] CTD PMID:25875864 NCBI chr 7:11,429,266...11,446,119
Ensembl chr 7:11,432,049...11,444,786 		JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 affects response to substance ISO ZC3H13 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr15:57,340,522...57,405,287
Ensembl chr15:57,340,579...57,405,287 		JBrowse link
G Zfp112 zinc finger protein 112 affects response to substance ISO ZNF112 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr 1:80,944,118...80,959,072
Ensembl chr 1:80,953,275...80,958,908 		JBrowse link
G Zfp655 zinc finger protein 655 affects response to substance ISO ZNF655 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 NCBI chr12:11,122,779...11,146,182
Ensembl chr12:11,127,754...11,144,754 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    chemical entity 19840
      atom 19838
        nonmetal atom 19718
          nitrogen atom 18612
            nitrogen molecular entity 18612
              triazene derivative 227
                2-\{(2E)-1-benzyl-3-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]triaz-2-en-1-yl\}ethyl acetate 0
                MTIC 0
                dacarbazine 22
                diminazene 2
                temozolomide 212
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    main group molecular entity 19730
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18743
                            inorganic hydride 17482
                              pnictogen hydride 17455
                                nitrogen hydride 17300
                                  triazene 227
                                    triazene derivative 227
                                      2-\{(2E)-1-benzyl-3-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]triaz-2-en-1-yl\}ethyl acetate 0
                                      MTIC 0
                                      dacarbazine 22
                                      diminazene 2
                                      temozolomide 212
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