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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isoflavans
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Accession:CHEBI:72572 term browser browse the term
Definition:Any isoflavonoid with a 3,4-dihydro-3-aryl-2H-1-benzopyran skeleton and its substituted derivatives.
Synonyms:related_synonym: Formula=C15HOR13;   SMILES=[*]c1c([*])c([*])c(C2C([*])([*])Oc3c([*])c([*])c([*])c([*])c3C2([*])[*])c([*])c1[*]


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alpinumisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects localization ISO alpinumisoflavone affects the localization of BAX protein CTD PMID:23850732 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO alpinumisoflavone results in decreased expression of BCL2 protein CTD PMID:23850732 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO alpinumisoflavone results in decreased expression of BID protein CTD PMID:23850732 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein
alpinumisoflavone results in increased cleavage of CASP3 protein		 CTD PMID:23850732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO alpinumisoflavone results in increased cleavage of CASP9 protein
[alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein		 CTD PMID:23850732 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO alpinumisoflavone results in decreased expression of CHUK protein CTD PMID:23850732 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO alpinumisoflavone affects the localization of CYCS protein CTD PMID:23850732 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein; [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein CTD PMID:23850732 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19091749 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alpinumisoflavone results in increased cleavage of PARP1 protein CTD PMID:23850732 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alpinumisoflavone results in decreased expression of RELA protein CTD PMID:23850732 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT3 protein CTD PMID:23850732 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:23850732 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT6 protein CTD PMID:23850732 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
Auriculasin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions		 ISO auriculasin affects the localization of AIFM1 protein
[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein]		 CTD PMID:30817944 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein] CTD PMID:30236598 PMID:30817944 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein] CTD PMID:30817944 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO auriculasin results in decreased expression of BCL2 protein
[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein]		 CTD PMID:30236598 PMID:30817944 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO auriculasin results in decreased expression of BCL2L1 protein CTD PMID:30236598 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein] CTD PMID:30817944 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein] CTD PMID:30817944 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein] CTD PMID:30817944 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
decreases activity
multiple interactions		 ISO CYP2C9 protein results in increased metabolism of auriculasin
auriculasin results in decreased activity of CYP2C9 protein
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of auriculasin]		 CTD PMID:31515991 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions		 ISO CYP2C19 protein results in increased metabolism of auriculasin
Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]		 CTD PMID:31515991 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions		 ISO CYP2C8 protein results in increased metabolism of auriculasin
Quercetin inhibits the reaction [CYP2C8 protein results in increased metabolism of auriculasin]		 CTD PMID:31515991
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing		 ISO Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin] CTD PMID:31515991 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO auriculasin results in decreased activity of CYP3A4 protein CTD PMID:31515991 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO [TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein]
auriculasin results in increased expression of DDIT3 protein		 CTD PMID:30817944 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Endog endonuclease G multiple interactions
affects localization		 ISO [TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein
auriculasin affects the localization of ENDOG protein		 CTD PMID:30817944 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein] CTD PMID:30236598 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] CTD PMID:30236598 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] CTD PMID:30236598 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein] CTD PMID:30236598 PMID:30817944 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein] CTD PMID:30817944 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:30236598 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] affects the expression of CASP10 protein; [auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] CTD PMID:30817944 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] CTD PMID:30817944 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO auriculasin results in decreased activity of UGT1A6 protein CTD PMID:31515991 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 decreases activity ISO auriculasin results in decreased activity of UGT1A8 protein CTD PMID:31515991 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]
auriculasin results in decreased expression of VEGFA protein		 CTD PMID:30236598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
cajanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein CTD PMID:20638373 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO cajanol results in decreased expression of BCL2 protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein		 CTD PMID:20638373 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein
cajanol results in increased activity of CASP3 protein		 CTD PMID:20638373 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein
cajanol results in increased activity of CASP9 protein		 CTD PMID:20638373 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO cajanol affects the localization of CYCS protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein		 CTD PMID:20638373 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
equol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Equol binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Equol results in increased phosphorylation of AKT1 protein CTD PMID:16840783 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpg alkaline phosphatase, germ cell increases expression ISO Equol results in increased expression of ALPG mRNA CTD PMID:15993745 NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836 		JBrowse link
G Ar androgen receptor affects binding EXP Equol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Casp3 caspase 3 increases activity ISO Equol results in increased activity of CASP3 protein CTD PMID:18973749 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases cleavage ISO Equol results in increased cleavage of CASP6 protein CTD PMID:18973749 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO Equol results in increased cleavage of CASP7 protein CTD PMID:18973749 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Equol results in increased cleavage of CASP9 protein CTD PMID:18973749 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Equol inhibits the reaction [NOS3 protein binds to CAV1 protein] CTD PMID:16840783 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Equol results in decreased expression of CCNA2 mRNA CTD PMID:16865672 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Equol results in decreased expression of CCNB2 mRNA CTD PMID:16865672 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Equol inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] CTD PMID:21945492 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Equol results in decreased expression of CDC25B mRNA CTD PMID:16865672 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Equol results in decreased expression of CDC25C mRNA CTD PMID:16865672 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide decreases expression EXP Equol results in decreased expression of CGA mRNA CTD PMID:23220561 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Equol results in decreased expression of CHEK1 mRNA CTD PMID:16865672 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Equol affects the localization of CYCS protein CTD PMID:18973749 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Equol results in decreased expression of CYP11A1 mRNA CTD PMID:26876617 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Equol results in decreased expression of CYP17A1 mRNA CTD PMID:26876617 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Equol results in decreased expression of CYP19A1 mRNA CTD PMID:26876617 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Dbf4 DBF4 zinc finger decreases expression ISO Equol results in decreased expression of DBF4 mRNA CTD PMID:16865672 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases activity ISO Equol results in increased activity of DFFA protein CTD PMID:18973749 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dusp4 dual specificity phosphatase 4 decreases expression ISO Equol results in decreased expression of DUSP4 mRNA CTD PMID:16865672 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased chemical synthesis of Oxygen]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein] CTD PMID:21300668 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression
increases activity
affects binding		 ISO
EXP		 [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; [fulvestrant binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; Equol binds to and results in increased activity of ESR1 protein; Estradiol affects the reaction [Equol affects the activity of ESR1 protein]
Equol results in increased expression of ESR1 mRNA; Equol results in increased expression of ESR1 mRNA alternative form
Equol results in increased activity of ESR1 protein
Equol binds to ESR1 protein		 CTD PMID:15876408 PMID:15993745 PMID:16118406 PMID:16965913 PMID:19427779 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
affects binding		 ISO Equol binds to and results in increased activity of ESR2 protein; Equol inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]; Equol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]; Estradiol affects the reaction [Equol affects the activity of ESR2 protein]
Equol results in increased activity of ESR2 protein
Equol binds to ESR2 protein		 CTD PMID:12224631 PMID:15084758 PMID:15993745 PMID:16118406 PMID:16965913 More... NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Equol results in decreased expression of GNRHR mRNA CTD PMID:23220561 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO Equol results in decreased expression of IGF1R mRNA CTD PMID:16865672 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il4 interleukin 4 increases expression ISO Equol results in increased expression of IL4 mRNA; Equol results in increased expression of IL4 protein CTD PMID:16108819 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kat5 lysine acetyltransferase 5 multiple interactions ISO Equol inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]; Equol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein] CTD PMID:23857583 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Equol results in decreased expression of LHB protein CTD PMID:23220561 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [U 0126 results in decreased phosphorylation of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Equol; AG 1879 inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; Equol results in increased activity of and results in increased phosphorylation of MAPK1 protein; Pertussis Toxin inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of MAPK1 protein] CTD PMID:16840783 PMID:19427779 PMID:21300668 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [U 0126 results in decreased phosphorylation of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Equol; AG 1879 inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; Equol results in increased activity of and results in increased phosphorylation of MAPK3 protein; Pertussis Toxin inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of MAPK3 protein] CTD PMID:16840783 PMID:19427779 PMID:21300668 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Equol results in decreased expression of MCM4 mRNA CTD PMID:16865672 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Equol results in increased expression of ME1 mRNA CTD PMID:16865672 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO Equol results in decreased expression of NKX3-1 mRNA CTD PMID:16865672 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; Equol inhibits the reaction [NOS3 protein binds to CAV1 protein]; Equol results in increased activity of and results in increased phosphorylation of NOS3 protein; Equol results in increased phosphorylation of and results in increased activity of NOS3 protein; Manganese inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; Pertussis Toxin inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; Rotenone inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein] CTD PMID:16840783 PMID:21300668 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO Equol results in decreased expression of PRIM2 mRNA CTD PMID:16865672 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030 		JBrowse link
G Prl prolactin increases expression EXP Equol results in increased expression of PRL protein CTD PMID:23220561 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Equol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Equol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16870006 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Equol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein] CTD PMID:21300668 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stk39 serine threonine kinase 39 decreases expression ISO Equol results in decreased expression of STK39 mRNA CTD PMID:16865672 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Equol results in increased expression of TFF1 mRNA CTD PMID:16965913 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO Equol results in decreased expression of THBS1 mRNA CTD PMID:16865672 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Equol CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Equol CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Equol CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression ISO Equol results in increased expression of UGT2B17 mRNA CTD PMID:16865672 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
glabridin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [glabridin affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin CTD PMID:18204840 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO glabridin results in increased cleavage of CASP8 protein CTD PMID:29663662 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO glabridin results in increased cleavage of CASP9 protein CTD PMID:29663662 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO glabridin inhibits the reaction [Antimycin A affects the localization of CYCS protein] CTD PMID:21621525 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO glabridin results in increased phosphorylation of MAPK1 protein CTD PMID:29663662 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO glabridin results in increased phosphorylation of MAPK3 protein CTD PMID:29663662 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO glabridin results in increased cleavage of PARP1 protein CTD PMID:29663662 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
glycyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO glycyrin results in decreased activity of DYRK1A protein CTD PMID:31838052 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
Isoangustone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO isoangustone A results in increased cleavage of CASP3 protein CTD PMID:20229524 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO isoangustone A results in increased cleavage of CASP7 protein CTD PMID:20229524 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO isoangustone A results in increased cleavage of CASP9 protein CTD PMID:20229524 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased expression of CCL2 mRNA] CTD PMID:21367880 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO isoangustone A results in decreased expression of CCND1 protein CTD PMID:21429724 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO isoangustone A results in decreased expression of and results in decreased activity of CDK2 protein CTD PMID:21429724 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO isoangustone A results in decreased expression of CDK4 protein CTD PMID:21429724 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:21367880 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO isoangustone A results in increased expression of MCL1 protein CTD PMID:20229524 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in decreased expression of MMP14 protein] CTD PMID:21367880 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO isoangustone A inhibits the reaction [Glucose affects the localization of RELA protein] CTD PMID:21367880 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:21367880 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:21367880 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased expression of TGFB1 protein] CTD PMID:21367880 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR1 protein] CTD PMID:21367880 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR2 protein] CTD PMID:21367880 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein] CTD PMID:21367880 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression
affects response to substance		 ISO isoangustone A results in increased expression of TNFRSF10A protein
TNFRSF10A mRNA affects the susceptibility to isoangustone A		 CTD PMID:20229524 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
licoricidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO [Gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with Gemcitabine] results in decreased phosphorylation of AKT1 protein
licoricidin results in decreased phosphorylation of AKT1 protein		 CTD PMID:29782821 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO licoricidin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [Gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; licoricidin results in increased expression of and results in increased activity of CASP3 protein
licoricidin results in increased activity of CASP3 protein		 CTD PMID:29782821 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation		 ISO licoricidin inhibits the reaction [Gemcitabine results in increased phosphorylation of RELA protein]
licoricidin results in decreased phosphorylation of RELA protein		 CTD PMID:29782821 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Lupalbigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO lupalbigenin results in decreased phosphorylation of AKT1 protein CTD PMID:25964563 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO lupalbigenin results in decreased expression of BCL2 protein CTD PMID:25964563 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO lupalbigenin results in decreased phosphorylation of MAPK1 protein CTD PMID:25964563 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO lupalbigenin results in decreased phosphorylation of MAPK3 protein CTD PMID:25964563 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
Osajin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases expression ISO osajin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Aqp1 aquaporin 1 increases expression ISO osajin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO osajin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Ar androgen receptor decreases expression ISO osajin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO osajin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO osajin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO osajin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cygb cytoglobin decreases expression ISO osajin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO osajin results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:11,798,905...11,833,415
Ensembl chr18:11,798,900...11,830,818 		JBrowse link
G Egf epidermal growth factor decreases expression ISO osajin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO osajin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO osajin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Grn granulin precursor increases expression ISO osajin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Has1 hyaluronan synthase 1 decreases expression ISO osajin results in decreased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO osajin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO osajin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO osajin results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Kl Klotho decreases expression ISO osajin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Krt5 keratin 5 increases expression ISO osajin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO osajin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO osajin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO osajin results in decreased expression of NOS2 mRNA CTD PMID:20706672 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO osajin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pgr progesterone receptor decreases expression ISO osajin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO osajin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960 		JBrowse link
G Pomc proopiomelanocortin decreases expression ISO osajin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO osajin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO osajin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO osajin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO osajin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO osajin results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO osajin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO osajin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO osajin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO osajin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO osajin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
Pomiferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases expression ISO pomiferin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Aqp1 aquaporin 1 increases expression ISO pomiferin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO pomiferin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Ar androgen receptor decreases expression ISO pomiferin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO pomiferin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO pomiferin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO pomiferin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cygb cytoglobin decreases expression ISO pomiferin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Egf epidermal growth factor decreases expression ISO pomiferin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO pomiferin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO pomiferin results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO pomiferin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Grn granulin precursor increases expression ISO pomiferin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO pomiferin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO pomiferin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Kl Klotho decreases expression ISO pomiferin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Krt5 keratin 5 increases expression ISO pomiferin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO pomiferin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO pomiferin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO pomiferin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pgr progesterone receptor decreases expression ISO pomiferin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO pomiferin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960 		JBrowse link
G Pomc proopiomelanocortin decreases expression ISO pomiferin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO pomiferin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO pomiferin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO pomiferin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO pomiferin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO pomiferin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO pomiferin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO pomiferin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO pomiferin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO pomiferin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO pomiferin results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    chemical entity 19816
      atom 19816
        nonmetal atom 19749
          oxygen atom 19524
            oxygen molecular entity 19524
              flavonoids 11380
                isoflavonoid 3794
                  isoflavans 129
                    hydroxyisoflavans + 56
                    isoflavan + 12
                    isoflavanones + 88
                    methoxyisoflavan + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  oxacycle 17770
                                    benzopyran 11699
                                      1-benzopyran 11461
                                        isoflavonoid 3794
                                          isoflavans 129
                                            hydroxyisoflavans + 56
                                            isoflavan + 12
                                            isoflavanones + 88
                                            methoxyisoflavan + 3
paths to the root