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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methyl 5-aminolevulinate
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Accession:CHEBI:724125 term browser browse the term
Definition:The methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumulation of protoporphyrin IX in the skin lesions to which the cream has been applied. Subsequent illumination with red light results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells.
Synonyms:exact_synonym: methyl 5-amino-4-oxopentanoate
 related_synonym: 5-aminolevulinic acid methyl ester;   Formula=C6H11NO3;   InChI=1S/C6H11NO3/c1-10-6(9)3-2-5(8)4-7/h2-4,7H2,1H3;   InChIKey=YUUAYBAIHCDHHD-UHFFFAOYSA-N;   Methyl aminolevulinate;   SMILES=COC(=O)CCC(=O)CN;   aminolevulinic acid methyl ester;   methyl delta-aminolevulinate
 xref: CAS:33320-16-0;   DrugBank:DB00992;   Drug_Central:168;   KEGG:D08204;   PMID:21197524;   PMID:21254852;   PMID:21978711;   PMID:22582911;   PMID:22785615;   PMID:22949035;   PMID:22971196;   PMID:23046014;   PMID:23212624;   Reaxys:5921212;   Wikipedia:Methyl_Aminolevulinate

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Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      application 19675
        pro-agent 11550
          prodrug 11310
            methyl 5-aminolevulinate 0
              methyl 5-aminolevulinate hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            heteroorganic entity 19494
                              organochalcogen compound 19257
                                organooxygen compound 19173
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18012
                                        fatty acid 16843
                                          saturated fatty acid 16563
                                            straight-chain saturated fatty acid 16092
                                              valeric acid 14530
                                                oxopentanoic acid 27
                                                  4-oxopentanoic acid 27
                                                    5-aminolevulinic acid 27
                                                      methyl 5-aminolevulinate 0
                                                        methyl 5-aminolevulinate hydrochloride 0
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