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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cabozantinib
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Accession:CHEBI:72317 term browser browse the term
Definition:A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.
Synonyms:exact_synonym: N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
 related_synonym: BMS 907351;   Formula=C28H24FN3O5;   InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);   InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N;   SMILES=COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC;   XL-184;   XL184
 xref: CAS:849217-68-1;   Drug_Central:4715;   KEGG:D10062;   LINCS:LSM-1195
 xref_mesh: MESH:C558660
 xref: PMID:20127563;   PMID:21314233;   PMID:21460789;   PMID:21606412;   PMID:21613405;   PMID:21860001;   PMID:21862995;   PMID:21926191;   PMID:22146228;   PMID:22585997;   PMID:23104465;   PMID:23169517;   PMID:23248244;   PMID:23292257;   PMID:23292795;   PMID:23319755;   PMID:23319797;   PMID:23319867;   PMID:23335077;   PMID:23337762;   PMID:23337763;   PMID:23375349;   Patent:WO2012109510;   Reaxys:18631644;   Wikipedia:Cabozantinib



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cabozantinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP3A4 polymorphism affects the metabolism of cabozantinib; CYP3A4 protein alternative form affects the metabolism of cabozantinib
CYP3A4 protein results in increased metabolism of cabozantinib
Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]
CTD PMID:31293154 PMID:34648813 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO cabozantinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases phosphorylation ISO cabozantinib results in decreased phosphorylation of MET protein CTD PMID:31639374 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      application 19663
        pharmaceutical 19504
          drug 19504
            antineoplastic agent 17765
              cabozantinib 3
                cabozantinib malate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      carboacyl group 17703
                                        univalent carboacyl group 17703
                                          carbamoyl group 17554
                                            carboxamide 17554
                                              dicarboxylic acid amide 3151
                                                dicarboxylic acid diamide 2698
                                                  cabozantinib 3
                                                    cabozantinib malate 0
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