Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:72317 term browser browse the term
Definition:A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.
Synonyms:exact_synonym: N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
 related_synonym: BMS 907351;   Formula=C28H24FN3O5;   InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);   InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N;   SMILES=COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC;   XL-184;   XL184
 xref: CAS:849217-68-1;   Drug_Central:4715;   KEGG:D10062;   LINCS:LSM-1195
 xref_mesh: MESH:C558660
 xref: PMID:20127563;   PMID:21314233;   PMID:21460789;   PMID:21606412;   PMID:21613405;   PMID:21860001;   PMID:21862995;   PMID:21926191;   PMID:22146228;   PMID:22585997;   PMID:23104465;   PMID:23169517;   PMID:23248244;   PMID:23292257;   PMID:23292795;   PMID:23319755;   PMID:23319797;   PMID:23319867;   PMID:23335077;   PMID:23337762;   PMID:23337763;   PMID:23375349;   Patent:WO2012109510;   Reaxys:18631644;   Wikipedia:Cabozantinib

show annotations for term's descendants           Sort by:
cabozantinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP3A4 polymorphism affects the metabolism of cabozantinib; CYP3A4 protein alternative form affects the metabolism of cabozantinib
CYP3A4 protein results in increased metabolism of cabozantinib
Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]
CTD PMID:31293154 PMID:34648813 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO cabozantinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases phosphorylation ISO cabozantinib results in decreased phosphorylation of MET protein CTD PMID:31639374 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pharmaceutical 19499
          drug 19499
            antineoplastic agent 17689
              cabozantinib 3
                cabozantinib malate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        carboacyl group 17687
                                          univalent carboacyl group 17687
                                            carbamoyl group 17531
                                              carboxamide 17531
                                                dicarboxylic acid amide 3155
                                                  dicarboxylic acid diamide 2700
                                                    cabozantinib 3
                                                      cabozantinib malate 0
paths to the root