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ONTOLOGY REPORT - ANNOTATIONS


Term:cabozantinib
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Accession:CHEBI:72317 term browser browse the term
Definition:A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.
Synonyms:exact_synonym: N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
 related_synonym: BMS 907351;   Formula=C28H24FN3O5;   InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);   InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N;   SMILES=COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC;   XL-184;   XL184
 xref: CAS:849217-68-1;   Drug_Central:4715;   KEGG:D10062;   LINCS:LSM-1195
 xref_mesh: MESH:C558660
 xref: PMID:20127563;   PMID:21314233;   PMID:21460789;   PMID:21606412;   PMID:21613405;   PMID:21860001;   PMID:21862995;   PMID:21926191;   PMID:22146228;   PMID:22585997;   PMID:23104465;   PMID:23169517;   PMID:23248244;   PMID:23292257;   PMID:23292795;   PMID:23319755;   PMID:23319797;   PMID:23319867;   PMID:23335077;   PMID:23337762;   PMID:23337763;   PMID:23375349;   Patent:WO2012109510;   Reaxys:18631644;   Wikipedia:Cabozantinib


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cabozantinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19789
    role 19735
      application 19381
        pharmaceutical 19251
          drug 19251
            antineoplastic agent 16918
              cabozantinib 2
                cabozantinib malate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19789
    subatomic particle 19787
      composite particle 19787
        hadron 19787
          baryon 19787
            nucleon 19787
              atomic nucleus 19787
                atom 19787
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19569
                        carbon atom 19558
                          organic molecular entity 19558
                            organic group 18473
                              organic divalent group 18467
                                organodiyl group 18467
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18038
                                        carboacyl group 17193
                                          univalent carboacyl group 17193
                                            carbamoyl group 16931
                                              carboxamide 16931
                                                dicarboxylic acid amide 3093
                                                  dicarboxylic acid diamide 2643
                                                    cabozantinib 2
                                                      cabozantinib malate 0
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