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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:virulence factor
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Accession:CHEBI:72316 term browser browse the term
Definition:Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host.
Synonyms:related_synonym: virulence factors
 xref: PMID:22851449;   Wikipedia:Virulence_factor



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lipoarabinomannan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 multiple interactions ISO CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO lipoarabinomannan results in decreased expression of CXCR2 protein CTD PMID:10950785 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Il12b interleukin 12B multiple interactions ISO lipoarabinomannan inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:16263713 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression
increases expression
ISO lipoarabinomannan results in increased expression of IRAK3 protein
Lipoarabinomannan increases expression of Irak3 mRNA and protein in macrophages
CTD
RGD
PMID:16263713 PMID:16263713 RGD:36049804 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity ISO lipoarabinomannan results in increased activity of MMP9 protein CTD PMID:11839551 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of NFKB1 protein CTD PMID:16263713 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO lipoarabinomannan results in decreased phosphorylation of NFKBIA protein CTD PMID:16263713 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of REL protein CTD PMID:16263713 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
pyocyanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression
multiple interactions
ISO Pyocyanine results in increased expression of AHR mRNA
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter]
CTD PMID:28476168 PMID:31078726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:24015256 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atf6 activating transcription factor 6 increases activity EXP Pyocyanine results in increased activity of ATF6 protein CTD PMID:27613716 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein CTD PMID:31078726 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Pyocyanine results in increased expression of CTNNB1 mRNA CTD PMID:31078726 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Pyocyanine results in increased expression of CYP1A1 mRNA CTD PMID:31078726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO Pyocyanine results in increased phosphorylation of EGFR protein CTD PMID:24015256 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Pyocyanine results in decreased expression of FABP4 mRNA CTD PMID:31078726 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Pyocyanine results in increased expression of GCLC mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]
CTD PMID:24015256 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity EXP Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Il10 interleukin 10 increases expression ISO Pyocyanine results in increased expression of IL10 protein CTD PMID:31078726 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 decreases expression ISO Pyocyanine results in decreased expression of IL13 protein CTD PMID:31078726 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il6 interleukin 6 increases expression ISO Pyocyanine results in increased expression of IL6 protein CTD PMID:31078726 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] CTD PMID:24015256 PMID:24316274 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Pyocyanine results in increased phosphorylation of MAPK3 protein
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:24015256 PMID:24316274 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
Pyocyanine results in increased activity of NFE2L2 protein
CTD PMID:24015256 PMID:27613716 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Pyocyanine results in increased expression of NQO1 mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
CTD PMID:24015256 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Pyocyanine results in decreased expression of PPARG mRNA CTD PMID:31078726 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] CTD PMID:28476168 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Pyocyanine results in increased expression of TNF mRNA CTD PMID:31078726 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        poison 18475
          toxin 15296
            virulence factor 32
              1,8-dihydroxynaphthalene-melanin 0
              aerobactin 0
              ferric yersiniabactin 0
              galactosaminogalactan 0
              lipoarabinomannan 10
              pyocyanine 22
              staphyloxanthin 0
              toxoflavin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        biochemical role 19624
          metabolite 19605
            toxin 15296
              virulence factor 32
                1,8-dihydroxynaphthalene-melanin 0
                aerobactin 0
                ferric yersiniabactin 0
                galactosaminogalactan 0
                lipoarabinomannan 10
                pyocyanine 22
                staphyloxanthin 0
                toxoflavin 0
paths to the root