Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pasireotide
go back to main search page
Accession:CHEBI:72312 term browser browse the term
Definition:A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease.
Synonyms:exact_synonym: cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-benzyl-L-tyrosyl-L-phenylalanyl-(4R)-4-{[(2-aminoethyl)carbamoyl]oxy}-L-prolyl]
 related_synonym: Formula=C58H66N10O9;   InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46+,47+,48-,49+,50+,51+/m1/s1;   InChIKey=VMZMNAABQBOLAK-DBILLSOUSA-N;   SMILES=NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O)OC(=O)NCCN)c1ccccc1;   SOM 230;   SOM230;   cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-);   pasireotida;   pasireotidum
 alt_id: MESH:C517782
 xref: CAS:396091-73-9;   KEGG:D10147
 xref_mesh: MESH:C517782
 xref: PMID:20643121;   PMID:20970474;   PMID:21264796;   PMID:21330405;   PMID:21493671;   PMID:21506098;   PMID:21525729;   PMID:21532334;   PMID:21673137;   PMID:21732759;   PMID:22170729;   PMID:22282526;   PMID:22383336;   PMID:22573933;   PMID:22634958;   PMID:22713526;   PMID:22736724;   PMID:22745760;   PMID:22807497;   PMID:22960304;   PMID:22965070;   PMID:23102680;   PMID:23137853;   PMID:23345100;   Reaxys:9469122;   Wikipedia:Pasireotide
 cyclic_relationship: is_conjugate_base_of CHEBI:72315


show annotations for term's descendants           Sort by:
pasireotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP
ISO		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]] CTD PMID:23137853 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA] CTD PMID:23137853 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions EXP
ISO		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]
pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]		 CTD PMID:23137853 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions EXP NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]] CTD PMID:23137853 NCBI chr 3:98,618,423...98,631,859
Ensembl chr 3:98,616,571...98,631,859 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein multiple interactions ISO pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330 		JBrowse link
G Nog noggin multiple interactions EXP NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Smad6 SMAD family member 6 decreases expression ISO pasireotide results in decreased expression of SMAD6 mRNA CTD PMID:23137853 NCBI chr 9:63,860,358...63,929,374
Ensembl chr 9:63,860,358...63,929,341 		JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO pasireotide results in decreased expression of SMAD7 mRNA CTD PMID:23137853 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Sstr1 somatostatin receptor 1 affects binding ISO pasireotide binds to SSTR1 protein CTD PMID:16625840 NCBI chr12:58,258,524...58,262,822
Ensembl chr12:58,258,558...58,260,673 		JBrowse link
G Sstr2 somatostatin receptor 2 affects binding ISO pasireotide binds to SSTR2 protein CTD PMID:16625840 NCBI chr11:113,510,153...113,516,854
Ensembl chr11:113,510,168...113,516,854 		JBrowse link
G Sstr3 somatostatin receptor 3 affects binding ISO pasireotide binds to SSTR3 protein CTD PMID:16625840 NCBI chr15:78,421,214...78,433,565
Ensembl chr15:78,421,208...78,428,885 		JBrowse link
G Sstr4 somatostatin receptor 4 affects binding ISO pasireotide binds to SSTR4 protein CTD PMID:16625840 NCBI chr 2:148,237,297...148,238,684
Ensembl chr 2:148,237,264...148,238,687 		JBrowse link
G Sstr5 somatostatin receptor 5 affects binding ISO pasireotide binds to SSTR5 protein CTD PMID:16625840 NCBI chr17:25,708,849...25,716,262
Ensembl chr17:25,708,847...25,733,577 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        molecular messenger 19405
          hormone 18937
            peptide hormone 152
              pasireotide 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      carboacyl group 18299
                                        univalent carboacyl group 18299
                                          carbamoyl group 18110
                                            carboxamide 18110
                                              peptide 11233
                                                cyclic peptide 8986
                                                  homodetic cyclic peptide 8481
                                                    pasireotide 18
paths to the root