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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrithiamine
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Accession:CHEBI:72290 term browser browse the term
Definition:A pyridinium ion that is 3-(2-hydroxyethyl)-2-methylpyridine substituted at position 1 by a (4-amino-2-methylpyrimidin-5-yl)methyl group.
Synonyms:related_synonym: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium;   1-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-(2-HYDROXYETHYL)-2-METHYLPYRIDINIUM;   Formula=C14H19N4O;   InChI=1S/C14H19N4O/c1-10-12(5-7-19)4-3-6-18(10)9-13-8-16-11(2)17-14(13)15/h3-4,6,8,19H,5,7,9H2,1-2H3,(H2,15,16,17)/q+1;   InChIKey=PZWYDZMWPANLMB-UHFFFAOYSA-N;   SMILES=Cc1ncc(C[n+]2cccc(CCO)c2C)c(N)n1;   pyrithiamine cation
 alt_id: CHEBI:39662
 xref_mesh: MESH:D011745
 xref: PDBeChem:218;   Reaxys:3913157


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pyrithiamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfap glial fibrillary acidic protein increases expression EXP Pyrithiamine results in increased expression of GFAP protein CTD PMID:27984051 NCBI chr10:87,852,891...87,861,631 JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Pyrithiamine results in increased expression of ITGAM protein CTD PMID:27984051 NCBI chr 1:182,659,047...182,709,495 JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression EXP Pyrithiamine results in decreased expression of SLC2A1 protein CTD PMID:27984051 NCBI chr 5:132,717,196...132,745,416 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    chemical entity 19762
      molecular entity 19760
        ion 15930
          organic ion 8462
            organic cation 7317
              pyridinium ion 2404
                pyrithiamine 3
                  1-(4-amino-2-methylpyrimidin-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium bromide 0
                  pyrithiamine pyrophosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    main group molecular entity 19651
                      p-block molecular entity 19651
                        carbon group molecular entity 19570
                          organic molecular entity 19560
                            organic ion 8462
                              organic cation 7317
                                pyridinium ion 2404
                                  pyrithiamine 3
                                    1-(4-amino-2-methylpyrimidin-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium bromide 0
                                    pyrithiamine pyrophosphate 0
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