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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:72289 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid substited at position 1 by a 1-hydroxy-3-methylbutan-2-yl group and at position 6 by a 3-chloro-2-fluorobenzyl group (the S-enantiomer). It is used in combination therapy for the treatment of HIV-1 infection.
Synonyms:exact_synonym: 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: Formula=C23H23ClFNO5;   GS-9137;   InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1;   InChIKey=JUZYLCPPVHEVSV-LJQANCHMSA-N;   SMILES=COc1cc2n(cc(C(O)=O)c(=O)c2cc1Cc1cccc(Cl)c1F)[C@H](CO)C(C)C;   elvitegravirum
 xref: CAS:697761-98-1;   Drug_Central:4300;   KEGG:D06677;   LINCS:LSM-5647
 xref_mesh: MESH:C509700
 xref: PMID:20040702;   PMID:21044030;   PMID:21505303;   PMID:22015077;   PMID:22197635;   PMID:22256860;   PMID:22321026;   PMID:22347806;   PMID:22571404;   PMID:22766666;   PMID:22789987;   PMID:22886031;   PMID:22992351;   PMID:23028968;   PMID:23114768;   PMID:23123342;   PMID:23136357;   PMID:23231029;   PMID:23253887;   PMID:23337366;   PMID:23341902;   PMID:23372110;   Patent:WO2009089263;   Patent:WO2010137032;   Patent:WO2011004389;   Reaxys:10609264;   Wikipedia:Elvitegravir

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elvitegravir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO elvitegravir results in decreased expression of ALDH1A2 mRNA CTD PMID:34515794 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO elvitegravir results in increased expression of FGF8 mRNA CTD PMID:34515794 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      molecular entity 20054
        polyatomic entity 19984
          heteroatomic molecular entity 19921
            halide 18488
              organohalogen compound 18308
                organofluorine compound 12455
                  elvitegravir 2
                    Genvoya 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        aromatic carboxylic acid 11788
                                          quinolinemonocarboxylic acid 101
                                            elvitegravir 2
                                              Genvoya 0
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