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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chromone
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Accession:CHEBI:72013 term browser browse the term
Definition:The simplest member of the class of chromones that is 4H-chromene with an oxo group at position 4.
Synonyms:exact_synonym: 4H-chromen-4-one
 related_synonym: 1,4-benzopyrone;   1-benzopyran-4-one;   4-chromone;   4-oxo-4H-1-benzopyran;   Benzo-gamma-pyrone;   Formula=C9H6O2;   InChI=1S/C9H6O2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H;   InChIKey=OTAFHZMPRISVEM-UHFFFAOYSA-N;   SMILES=O=c1ccoc2ccccc12
 xref: CAS:491-38-3;   HMDB:HMDB0032938
 xref_mesh: MESH:C068515
 xref: Reaxys:114087;   Wikipedia:Chromone


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chromone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP3 protein modified form] CTD PMID:30256521 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP8 protein modified form] CTD PMID:30256521 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP9 protein modified form] CTD PMID:30256521 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 4-chromone analog results in increased expression of H2AX protein modified form CTD PMID:30256521 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO 4-chromone analog results in increased expression of PARP1 protein modified form
Acetylcysteine inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]
CTD PMID:30256521 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      atom 19766
        nonmetal atom 19645
          carbon atom 19563
            organic molecular entity 19563
              olefinic compound 15354
                enone 8964
                  chromone 5
                    2-(1,3-dihydroxy-4-oxocyclohexa-2,5-dien-1-yl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one 0
                    2-(2-(4-methoxyphenyl)ethyl)chromone 0
                    2-(2-phenylethyl)chromone 0
                    5,8-dihydroxy-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,7-dimethoxy-4H-chromen-4-one 0
                    5-hydroxy-6,7-dimethoxy-2-methylchromone 0
                    7-chloro-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,5,6,8-tetramethoxy-4H-chromen-4-one 0
                    eugenin 0
                    leptorumol 0
                    pisonin A 0
                    pisonin B 0
                    pisonin C 0
                    pisonin F 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                organic heterocyclic compound 18510
                                  oxacycle 17548
                                    benzopyran 10280
                                      1-benzopyran 10002
                                        chromenes 936
                                          chromenone 866
                                            chromones 417
                                              chromone 5
                                                2-(1,3-dihydroxy-4-oxocyclohexa-2,5-dien-1-yl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one 0
                                                2-(2-(4-methoxyphenyl)ethyl)chromone 0
                                                2-(2-phenylethyl)chromone 0
                                                5,8-dihydroxy-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,7-dimethoxy-4H-chromen-4-one 0
                                                5-hydroxy-6,7-dimethoxy-2-methylchromone 0
                                                7-chloro-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,5,6,8-tetramethoxy-4H-chromen-4-one 0
                                                eugenin 0
                                                leptorumol 0
                                                pisonin A 0
                                                pisonin B 0
                                                pisonin C 0
                                                pisonin F 0
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