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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chromone
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Accession:CHEBI:72013 term browser browse the term
Definition:The simplest member of the class of chromones that is 4H-chromene with an oxo group at position 4.
Synonyms:exact_synonym: 4H-chromen-4-one
 related_synonym: 1,4-benzopyrone;   1-benzopyran-4-one;   4-chromone;   4-oxo-4H-1-benzopyran;   Benzo-gamma-pyrone;   Formula=C9H6O2;   InChI=1S/C9H6O2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H;   InChIKey=OTAFHZMPRISVEM-UHFFFAOYSA-N;   SMILES=O=c1ccoc2ccccc12
 xref: CAS:491-38-3;   HMDB:HMDB0032938
 xref_mesh: MESH:C068515
 xref: Reaxys:114087;   Wikipedia:Chromone



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chromone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP3 protein modified form] CTD PMID:30256521 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP8 protein modified form] CTD PMID:30256521 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP9 protein modified form] CTD PMID:30256521 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 4-chromone analog results in increased expression of H2AX protein modified form CTD PMID:30256521 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO 4-chromone analog results in increased expression of PARP1 protein modified form
Acetylcysteine inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]
CTD PMID:30256521 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    chemical entity 20049
      atom 20048
        nonmetal atom 19936
          carbon atom 19863
            organic molecular entity 19863
              olefinic compound 16502
                enone 9932
                  chromone 5
                    2-(1,3-dihydroxy-4-oxocyclohexa-2,5-dien-1-yl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one 0
                    2-(2-(4-methoxyphenyl)ethyl)chromone 0
                    2-(2-phenylethyl)chromone 0
                    3-Methoxy-2-(4-methylbenzoyl)-4H-1-benzopyran-4-one 0
                    5,8-dihydroxy-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,7-dimethoxy-4H-chromen-4-one 0
                    5-hydroxy-6,7-dimethoxy-2-methylchromone 0
                    7-chloro-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,5,6,8-tetramethoxy-4H-chromen-4-one 0
                    eugenin 0
                    leptorumol 0
                    pisonin A 0
                    pisonin B 0
                    pisonin C 0
                    pisonin F 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  oxacycle 17705
                                    benzopyran 11209
                                      1-benzopyran 10949
                                        chromenes 3025
                                          chromenone 2965
                                            chromones 430
                                              chromone 5
                                                2-(1,3-dihydroxy-4-oxocyclohexa-2,5-dien-1-yl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one 0
                                                2-(2-(4-methoxyphenyl)ethyl)chromone 0
                                                2-(2-phenylethyl)chromone 0
                                                3-Methoxy-2-(4-methylbenzoyl)-4H-1-benzopyran-4-one 0
                                                5,8-dihydroxy-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,7-dimethoxy-4H-chromen-4-one 0
                                                5-hydroxy-6,7-dimethoxy-2-methylchromone 0
                                                7-chloro-2-(1-hydroxy-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl)-3,5,6,8-tetramethoxy-4H-chromen-4-one 0
                                                eugenin 0
                                                leptorumol 0
                                                pisonin A 0
                                                pisonin B 0
                                                pisonin C 0
                                                pisonin F 0
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