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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxyflavonoid
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Accession:CHEBI:71968 term browser browse the term
Definition:Any flavonoid in which one or more ring hydrogens are replaced by hydroxy groups.
Synonyms:related_synonym: hydroxyflavonoids


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6-Hydroxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
multiple interactions		 ISO 6-hydroxyflavone results in increased activity of CYP3A4 protein
[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam		 CTD PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 6-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
7-hydroxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions ISO 7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO 7-hydroxyflavone results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP19A1 protein CTD PMID:15319488 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A1 protein CTD PMID:21053930 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO 7-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases activity
multiple interactions		 ISO 7-hydroxyflavone results in decreased activity of CYP3A4 protein
7-hydroxyflavone results in increased activity of CYP3A4 protein
[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam		 CTD PMID:21053930 PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 7-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity		 ISO 7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
7-hydroxyflavone results in decreased activity of SLC2A1 protein		 CTD PMID:14642735 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Tricetinidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression EXP tricetinidin results in increased expression of HMOX1 protein CTD PMID:30266311 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      atom 20058
        nonmetal atom 19979
          oxygen atom 19674
            oxygen molecular entity 19674
              flavonoids 11202
                flavonoid 6575
                  hydroxyflavonoid 11
                    (+)-Myristinin A 0
                    (2,6-dihydroxy-4-\{4-hydroxy-7-methyl-11-oxo-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-3-yl\}phenoxy)dihydroxyoxo-?-sulfanylium 0
                    (6-carboxy-3,4,5-trihydroxyoxan-2-yl)[2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7H-chromen-7-ylidene]oxidanium 0
                    (6-carboxy-3,4,5-trihydroxyoxan-2-yl)[3,5-dihydroxy-2-(2,3,4-trihydroxyphenyl)-7H-chromen-7-ylidene]oxidanium 0
                    1-[2,4,6-trihydroxy-3-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]phenyl]dodecan-1-one 0
                    2',5'-Dihydroxyflavone 0
                    2-(3,4-dihydroxyphenyl)-5-hydroxychromen-7-one 0
                    3'-Hydroxy-alpha-naphthoflavone 0
                    5'-hydroxy-3'-methoxyflavone + 0
                    6-Hydroxyflavone 2
                    7,2'-Dihydroxy-5,8-dimethyl-4',5'-methylenedioxyflavan 0
                    7,2'-Dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan 0
                    7,4'-Dihydroxy-8-methylflavan 0
                    7,4'-Dihydroxyflavan 0
                    7-Hydroxyflavan 0
                    7-hydroxyflavone + 10
                    Apigeniflavan 0
                    Apigeninidin 0
                    Aurantinidin 0
                    Cyanidin 7-arabinoside 0
                    Favan-3-ol 0
                    Kazinol A 0
                    Tricetinidin 1
                    \{4-hydroxy-7-[(sulfooxy)methyl]-3-(3,4,5-trihydroxyphenyl)-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene\}oxidanium 0
                    catechin 5-glucuronide 0
                    diinsinin 0
                    diinsininol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  oxacycle 17688
                                    benzopyran 11213
                                      1-benzopyran 10951
                                        flavonoid 6575
                                          hydroxyflavonoid 11
                                            (+)-Myristinin A 0
                                            (2,6-dihydroxy-4-\{4-hydroxy-7-methyl-11-oxo-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-3-yl\}phenoxy)dihydroxyoxo-?-sulfanylium 0
                                            (6-carboxy-3,4,5-trihydroxyoxan-2-yl)[2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7H-chromen-7-ylidene]oxidanium 0
                                            (6-carboxy-3,4,5-trihydroxyoxan-2-yl)[3,5-dihydroxy-2-(2,3,4-trihydroxyphenyl)-7H-chromen-7-ylidene]oxidanium 0
                                            1-[2,4,6-trihydroxy-3-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]phenyl]dodecan-1-one 0
                                            2',5'-Dihydroxyflavone 0
                                            2-(3,4-dihydroxyphenyl)-5-hydroxychromen-7-one 0
                                            3'-Hydroxy-alpha-naphthoflavone 0
                                            5'-hydroxy-3'-methoxyflavone + 0
                                            6-Hydroxyflavone 2
                                            7,2'-Dihydroxy-5,8-dimethyl-4',5'-methylenedioxyflavan 0
                                            7,2'-Dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan 0
                                            7,4'-Dihydroxy-8-methylflavan 0
                                            7,4'-Dihydroxyflavan 0
                                            7-Hydroxyflavan 0
                                            7-hydroxyflavone + 10
                                            Apigeniflavan 0
                                            Apigeninidin 0
                                            Aurantinidin 0
                                            Cyanidin 7-arabinoside 0
                                            Favan-3-ol 0
                                            Kazinol A 0
                                            Tricetinidin 1
                                            \{4-hydroxy-7-[(sulfooxy)methyl]-3-(3,4,5-trihydroxyphenyl)-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene\}oxidanium 0
                                            catechin 5-glucuronide 0
                                            diinsinin 0
                                            diinsininol 0
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