CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydroxyflavonoid
Accession: CHEBI:71968
browse the term
Definition: Any flavonoid in which one or more ring hydrogens are replaced by hydroxy groups.
Synonyms: related_synonym: hydroxyflavonoids
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases activity multiple interactions
ISO
6-hydroxyflavone results in increased activity of CYP3A4 protein [6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam
CTD
PMID:31756459
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
G
Pkm
pyruvate kinase M1/2
multiple interactions
ISO
6-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]
CTD
PMID:25388478
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
G
Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions
ISO
7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein
CTD
PMID:16962702
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
G
Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
7-hydroxyflavone results in decreased activity of AKR1C3 protein
CTD
PMID:19007764
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
7-hydroxyflavone results in decreased activity of CYP19A1 protein
CTD
PMID:15319488
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
7-hydroxyflavone results in decreased activity of CYP1A1 protein
CTD
PMID:21053930
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
7-hydroxyflavone results in decreased activity of CYP1A2 protein
CTD
PMID:21053930 PMID:29753067
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
7-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein
CTD
PMID:21053930
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases activity
ISO
7-hydroxyflavone results in decreased activity of CYP2C19 protein
CTD
PMID:29753067
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity increases activity multiple interactions
ISO
7-hydroxyflavone results in decreased activity of CYP3A4 protein 7-hydroxyflavone results in increased activity of CYP3A4 protein [7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam
CTD
PMID:21053930 PMID:31756459
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
G
Pkm
pyruvate kinase M1/2
multiple interactions
ISO
7-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]
CTD
PMID:25388478
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
G
Slc2a1
solute carrier family 2 member 1
multiple interactions decreases activity
ISO
7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose] 7-hydroxyflavone results in decreased activity of SLC2A1 protein
CTD
PMID:14642735
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
G
Hmox1
heme oxygenase 1
increases expression
EXP
tricetinidin results in increased expression of HMOX1 protein
CTD
PMID:30266311
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20089
chemical entity
20088
atom
20058
nonmetal atom
19979
oxygen atom
19674
oxygen molecular entity
19674
flavonoids
11202
flavonoid
6575
hydroxyflavonoid
11
(+)-Myristinin A
0
(2,6-dihydroxy-4-\{4-hydroxy-7-methyl-11-oxo-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-3-yl\}phenoxy)dihydroxyoxo-?-sulfanylium
0
(6-carboxy-3,4,5-trihydroxyoxan-2-yl)[2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7H-chromen-7-ylidene]oxidanium
0
(6-carboxy-3,4,5-trihydroxyoxan-2-yl)[3,5-dihydroxy-2-(2,3,4-trihydroxyphenyl)-7H-chromen-7-ylidene]oxidanium
0
1-[2,4,6-trihydroxy-3-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]phenyl]dodecan-1-one
0
2',5'-Dihydroxyflavone
0
2-(3,4-dihydroxyphenyl)-5-hydroxychromen-7-one
0
3'-Hydroxy-alpha-naphthoflavone
0
5'-hydroxy-3'-methoxyflavone +
0
6-Hydroxyflavone
2
7,2'-Dihydroxy-5,8-dimethyl-4',5'-methylenedioxyflavan
0
7,2'-Dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan
0
7,4'-Dihydroxy-8-methylflavan
0
7,4'-Dihydroxyflavan
0
7-Hydroxyflavan
0
7-hydroxyflavone +
10
Apigeniflavan
0
Apigeninidin
0
Aurantinidin
0
Cyanidin 7-arabinoside
0
Favan-3-ol
0
Kazinol A
0
Tricetinidin
1
\{4-hydroxy-7-[(sulfooxy)methyl]-3-(3,4,5-trihydroxyphenyl)-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene\}oxidanium
0
catechin 5-glucuronide
0
diinsinin
0
diinsininol
0
Path 2
CHEBI ontology
20089
subatomic particle
20058
composite particle
20058
hadron
20088
baryon
20088
nucleon
20088
atomic nucleus
20088
atom
20058
main group element atom
19960
p-block element atom
19990
carbon group element atom
19916
carbon atom
19909
organic molecular entity
19909
organic molecule
19856
organic cyclic compound
19612
organic heterocyclic compound
18824
oxacycle
17688
benzopyran
11213
1-benzopyran
10951
flavonoid
6575
hydroxyflavonoid
11
(+)-Myristinin A
0
(2,6-dihydroxy-4-\{4-hydroxy-7-methyl-11-oxo-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-3-yl\}phenoxy)dihydroxyoxo-?-sulfanylium
0
(6-carboxy-3,4,5-trihydroxyoxan-2-yl)[2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7H-chromen-7-ylidene]oxidanium
0
(6-carboxy-3,4,5-trihydroxyoxan-2-yl)[3,5-dihydroxy-2-(2,3,4-trihydroxyphenyl)-7H-chromen-7-ylidene]oxidanium
0
1-[2,4,6-trihydroxy-3-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]phenyl]dodecan-1-one
0
2',5'-Dihydroxyflavone
0
2-(3,4-dihydroxyphenyl)-5-hydroxychromen-7-one
0
3'-Hydroxy-alpha-naphthoflavone
0
5'-hydroxy-3'-methoxyflavone +
0
6-Hydroxyflavone
2
7,2'-Dihydroxy-5,8-dimethyl-4',5'-methylenedioxyflavan
0
7,2'-Dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan
0
7,4'-Dihydroxy-8-methylflavan
0
7,4'-Dihydroxyflavan
0
7-Hydroxyflavan
0
7-hydroxyflavone +
10
Apigeniflavan
0
Apigeninidin
0
Aurantinidin
0
Cyanidin 7-arabinoside
0
Favan-3-ol
0
Kazinol A
0
Tricetinidin
1
\{4-hydroxy-7-[(sulfooxy)methyl]-3-(3,4,5-trihydroxyphenyl)-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene\}oxidanium
0
catechin 5-glucuronide
0
diinsinin
0
diinsininol
0