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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyflavonoid
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Accession:CHEBI:71968 term browser browse the term
Definition:Any flavonoid in which one or more ring hydrogens are replaced by hydroxy groups.
Synonyms:related_synonym: hydroxyflavonoids


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6-Hydroxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
multiple interactions
ISO 6-hydroxyflavone results in increased activity of CYP3A4 protein
[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam
CTD PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 6-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
7-hydroxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO 7-hydroxyflavone results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP19A1 protein CTD PMID:15319488 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A1 protein CTD PMID:21053930 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO 7-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases activity
multiple interactions
ISO 7-hydroxyflavone results in decreased activity of CYP3A4 protein
7-hydroxyflavone results in increased activity of CYP3A4 protein
[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam
CTD PMID:21053930 PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 7-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO 7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
7-hydroxyflavone results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          oxygen atom 19445
            oxygen molecular entity 19445
              flavonoids 11135
                flavonoid 6513
                  hydroxyflavonoid 9
                    (+)-Myristinin A 0
                    (2,6-dihydroxy-4-\{4-hydroxy-7-methyl-11-oxo-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-3-yl\}phenoxy)dihydroxyoxo-?-sulfanylium 0
                    (6-carboxy-3,4,5-trihydroxyoxan-2-yl)[3,5-dihydroxy-2-(2,3,4-trihydroxyphenyl)-7H-chromen-7-ylidene]oxidanium 0
                    5'-hydroxy-3'-methoxyflavone + 0
                    6-Hydroxyflavone 2
                    7,4'-Dihydroxy-8-methylflavan 0
                    7,4'-Dihydroxyflavan 0
                    7-Hydroxyflavan 0
                    7-hydroxyflavone + 9
                    Apigeninidin 0
                    Aurantinidin 0
                    Favan-3-ol 0
                    Kazinol A 0
                    \{4-hydroxy-7-[(sulfooxy)methyl]-3-(3,4,5-trihydroxyphenyl)-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene\}oxidanium 0
                    catechin 5-glucuronide 0
                    diinsinin 0
                    diinsininol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  oxacycle 17587
                                    benzopyran 10402
                                      1-benzopyran 10129
                                        flavonoid 6513
                                          hydroxyflavonoid 9
                                            (+)-Myristinin A 0
                                            (2,6-dihydroxy-4-\{4-hydroxy-7-methyl-11-oxo-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-3-yl\}phenoxy)dihydroxyoxo-?-sulfanylium 0
                                            (6-carboxy-3,4,5-trihydroxyoxan-2-yl)[3,5-dihydroxy-2-(2,3,4-trihydroxyphenyl)-7H-chromen-7-ylidene]oxidanium 0
                                            5'-hydroxy-3'-methoxyflavone + 0
                                            6-Hydroxyflavone 2
                                            7,4'-Dihydroxy-8-methylflavan 0
                                            7,4'-Dihydroxyflavan 0
                                            7-Hydroxyflavan 0
                                            7-hydroxyflavone + 9
                                            Apigeninidin 0
                                            Aurantinidin 0
                                            Favan-3-ol 0
                                            Kazinol A 0
                                            \{4-hydroxy-7-[(sulfooxy)methyl]-3-(3,4,5-trihydroxyphenyl)-2,8-dioxatricyclo[7.3.1.0?,??]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene\}oxidanium 0
                                            catechin 5-glucuronide 0
                                            diinsinin 0
                                            diinsininol 0
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