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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:71954 term browser browse the term
Definition:An aminopyridine that is 4-(trifluoromethyl)pyridin-2-amine substituted at position 5 by a 2,6-di(morpholin-4-yl)pyrimidin-4-y group. A selective PI3K inhibitor with anti-tumour properties.
Synonyms:exact_synonym: 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
 related_synonym: BKM 120;   Formula=C18H21F3N6O2;   InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23);   InChIKey=CWHUFRVAEUJCEF-UHFFFAOYSA-N;   NVP-BKM120;   SMILES=Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F
 xref: CAS:1202777-78-3;   LINCS:LSM-1148;   PMID:21169255;   PMID:21362200;   PMID:22037215;   PMID:22049316;   PMID:22065080;   PMID:22159814;   PMID:22162589;   PMID:22188813;   PMID:22207485;   PMID:22355357;   PMID:22543857;   PMID:22619567;   PMID:22653967;   PMID:22682985;   PMID:22737248;   PMID:22781393;   PMID:22915751;   PMID:22915752;   PMID:23238639;   PMID:23300274;   PMID:23319457;   Patent:WO2007084786;   Patent:WO2012044727;   Patent:WO2012109423;   Reaxys:12938097

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BKM120 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 decreases expression EXP BKM120 decreases expression of cyclin E protein in rat pituitary tumor cell line RGD PMID:26983879 RGD:152177690 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Prl prolactin decreases expression EXP BKM120 decreases expression of prolactin protein in serum of treated rats RGD PMID:26983879 RGD:152177690 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      application 19770
        pharmaceutical 19645
          drug 19645
            antineoplastic agent 17656
              BKM120 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    main group molecular entity 19959
                      s-block molecular entity 19758
                        hydrogen molecular entity 19764
                          hydrides 19134
                            inorganic hydride 17935
                              pnictogen hydride 17901
                                nitrogen hydride 17789
                                  azane 17542
                                    ammonia 17541
                                      organic amino compound 17541
                                        aromatic amine 14924
                                          aminopyrimidine 1692
                                            BKM120 2
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