Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolmetin
go back to main search page
Accession:CHEBI:71941 term browser browse the term
Definition:A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Synonyms:exact_synonym: [1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
 related_synonym: 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid;   1-Methyl-5-p-toluoylpyrrole-2-acetic acid;   5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid;   Formula=C15H15NO3;   InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18);   InChIKey=UPSPUYADGBWSHF-UHFFFAOYSA-N;   SMILES=Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C;   tolmetina;   tolmetine;   tolmetino;   tolmetinum
 alt_id: CHEBI:9618
 xref: CAS:26171-23-3;   DrugBank:DB00500;   Drug_Central:2699;   HMDB:HMDB0014643;   KEGG:C07149;   KEGG:D02355;   LINCS:LSM-3852
 xref_mesh: MESH:D014046
 xref: PDBeChem:TLT;   PMID:1206489;   PMID:19181568;   PMID:19505209;   PMID:20529813;   PMID:20582193;   PMID:20853464;   PMID:21936545;   PMID:22005020;   PMID:22943177;   PMID:23333829;   PMID:3390998;   PMID:445955;   PMID:6686452;   PMID:8472518;   Patent:DE2836902;   Patent:MX2010012712;   Patent:WO2004069782;   Patent:WO2008017903;   Patent:WO2009072139;   Reaxys:485305;   Wikipedia:Tolmetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:72213

show annotations for term's descendants           Sort by:
 
tolmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Tolmetin binds to ALB protein CTD PMID:8027947 PMID:9353694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Tolmetin results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Tolmetin co-treated with Glucose] binds to PPARA protein; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Tolmetin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Tolmetin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity
multiple interactions		 EXP Tolmetin results in decreased activity of TDO2 protein
[Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin		 CTD PMID:16952380 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        anti-inflammatory agent 15836
          anti-inflammatory drug 13622
            non-steroidal anti-inflammatory drug 12711
              tolmetin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          tolmetin 6
paths to the root