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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolmetin
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Accession:CHEBI:71941 term browser browse the term
Definition:A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Synonyms:exact_synonym: [1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
 related_synonym: 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid;   1-Methyl-5-p-toluoylpyrrole-2-acetic acid;   5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid;   Formula=C15H15NO3;   InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18);   InChIKey=UPSPUYADGBWSHF-UHFFFAOYSA-N;   SMILES=Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C;   tolmetina;   tolmetine;   tolmetino;   tolmetinum
 alt_id: CHEBI:9618
 xref: CAS:26171-23-3;   DrugBank:DB00500;   Drug_Central:2699;   HMDB:HMDB0014643;   KEGG:C07149;   KEGG:D02355;   LINCS:LSM-3852
 xref_mesh: MESH:D014046
 xref: PDBeChem:TLT;   PMID:1206489;   PMID:19181568;   PMID:19505209;   PMID:20529813;   PMID:20582193;   PMID:20853464;   PMID:21936545;   PMID:22005020;   PMID:22943177;   PMID:23333829;   PMID:3390998;   PMID:445955;   PMID:6686452;   PMID:8472518;   Patent:DE2836902;   Patent:MX2010012712;   Patent:WO2004069782;   Patent:WO2008017903;   Patent:WO2009072139;   Reaxys:485305;   Wikipedia:Tolmetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:72213


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tolmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Tolmetin binds to ALB protein CTD PMID:8027947 PMID:9353694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Tolmetin results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Tolmetin co-treated with Glucose] binds to PPARA protein; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Tolmetin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Tolmetin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity
multiple interactions
EXP Tolmetin results in decreased activity of TDO2 protein
[Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin
CTD PMID:16952380 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        anti-inflammatory agent 15836
          anti-inflammatory drug 13622
            non-steroidal anti-inflammatory drug 12711
              tolmetin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          tolmetin 6
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