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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:71941 term browser browse the term
Definition:A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Synonyms:exact_synonym: [1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
 related_synonym: 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid;   1-Methyl-5-p-toluoylpyrrole-2-acetic acid;   5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid;   Formula=C15H15NO3;   InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18);   InChIKey=UPSPUYADGBWSHF-UHFFFAOYSA-N;   SMILES=Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C;   tolmetina;   tolmetine;   tolmetino;   tolmetinum
 alt_id: CHEBI:9618
 xref: CAS:26171-23-3;   DrugBank:DB00500;   Drug_Central:2699;   HMDB:HMDB0014643;   KEGG:C07149;   KEGG:D02355;   LINCS:LSM-3852
 xref_mesh: MESH:D014046
 xref: PDBeChem:TLT;   PMID:1206489;   PMID:19181568;   PMID:19505209;   PMID:20529813;   PMID:20582193;   PMID:20853464;   PMID:21936545;   PMID:22005020;   PMID:22943177;   PMID:23333829;   PMID:3390998;   PMID:445955;   PMID:6686452;   PMID:8472518;   Patent:DE2836902;   Patent:MX2010012712;   Patent:WO2004069782;   Patent:WO2008017903;   Patent:WO2009072139;   Reaxys:485305;   Wikipedia:Tolmetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:72213

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tolmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Tolmetin binds to ALB protein CTD PMID:8027947 PMID:9353694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Tolmetin results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Tolmetin co-treated with Glucose] binds to PPARA protein; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Tolmetin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Tolmetin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity
multiple interactions
EXP Tolmetin results in decreased activity of TDO2 protein
[Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin
CTD PMID:16952380 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        anti-inflammatory agent 14959
          anti-inflammatory drug 13619
            non-steroidal anti-inflammatory drug 12703
              tolmetin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        monocarboxylic acid 17475
                                          tolmetin 6
paths to the root