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ONTOLOGY REPORT - ANNOTATIONS


Term:tadalafil
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Accession:CHEBI:71940 term browser browse the term
Definition:A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR-diastereomer). A phosphodiesterase V inhibitor inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
Synonyms:exact_synonym: (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
 related_synonym: (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione;   (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione;   6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE;   Adcirca;   Cialis;   Formula=C22H19N3O4;   InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1;   InChIKey=WOXKDUGGOYFFRN-IIBYNOLFSA-N;   SMILES=[H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1
 alt_id: CHEBI:32177;   CHEBI:41488
 xref: CAS:171596-29-5;   DrugBank:DB00820;   Drug_Central:2553;   HMDB:HMDB0014958;   KEGG:D02008;   LINCS:LSM-4109
 xref_mesh: MESH:D000068581
 xref: PDBeChem:CIA;   PMID:21056623;   PMID:21680058;   PMID:22014651;   PMID:22328305;   PMID:22494518;   PMID:22776546;   PMID:22816778;   PMID:22971615;   PMID:22982422;   PMID:22996758;   PMID:23033484;   PMID:23072271;   PMID:23118430;   PMID:23140258;   PMID:23190275;   PMID:23216015;   PMID:23219525;   PMID:23234619;   PMID:23312193;   PMID:23346990;   PMID:23347176;   Patent:EP2107059;   Patent:EP2238979;   Patent:US2003229080;   Patent:US2004157847;   Patent:WO2005068464;   Patent:WO2007113243;   Patent:WO2009144734;   Patent:WO2010049500;   Patent:WO2012107549;   Reaxys:9589181;   Wikipedia:Tadalafil


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tadalafil term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:6480464
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:6480464
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:6480464
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:6480464
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Pde5a phosphodiesterase 5A JBrowse link 2 226,899,604 227,044,916 RGD:6480464
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

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  CHEBI ontology 19779
    role 19727
      application 19373
        pharmaceutical 19243
          drug 19243
            cardiovascular drug 7616
              vasodilator agent 5734
                tadalafil 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            organic molecule 19472
                              organic cyclic compound 19236
                                organic heterocyclic compound 18361
                                  organic heteropolycyclic compound 17707
                                    organic heterobicyclic compound 16488
                                      benzodioxoles 7672
                                        tadalafil 22
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.