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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diterpene glycoside
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Accession:CHEBI:71939 term browser browse the term
Definition:A terpene glycoside in which the terpene moiety is a diterpenoid.
Synonyms:related_synonym: diterpene glycosides


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rebaudioside A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 decreases expression ISO rebaudioside A results in decreased expression of ACE mRNA CTD PMID:31655124 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] CTD PMID:25554529 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression ISO rebaudioside A results in increased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO rebaudioside A results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Bax BCL2-associated X protein decreases expression ISO rebaudioside A results in decreased expression of BAX mRNA CTD PMID:31655124 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha increases expression ISO rebaudioside A results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Cat catalase multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] CTD PMID:25554529 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav1 caveolin 1, caveolae protein decreases expression ISO rebaudioside A results in decreased expression of CAV1 mRNA CTD PMID:31655124 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO rebaudioside A results in decreased expression of CCL2 mRNA CTD PMID:31655124 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO rebaudioside A results in decreased expression of CFLAR mRNA CTD PMID:31655124 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] CTD PMID:25554529 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] CTD PMID:25554529 NCBI chr 7:99,153,663...99,182,713
Ensembl chr 7:99,153,658...99,182,719
JBrowse link
G Edn1 endothelin 1 decreases expression ISO rebaudioside A results in decreased expression of EDN1 mRNA CTD PMID:31655124 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednra endothelin receptor type A increases expression ISO rebaudioside A results in increased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO rebaudioside A results in decreased expression of F2R mRNA CTD PMID:31655124 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO rebaudioside A results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO rebaudioside A results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:38,838,672...38,929,470
Ensembl chr18:38,838,673...38,929,472
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 decreases expression ISO rebaudioside A results in decreased expression of FLT1 mRNA CTD PMID:31655124 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] CTD PMID:25554529 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G G6pc glucose-6-phosphatase, catalytic multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA] CTD PMID:25554529 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G Insr insulin receptor multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] CTD PMID:25554529 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 NCBI chr 8:10,984,681...11,008,929
Ensembl chr 8:10,984,681...11,008,458
JBrowse link
G Itgav integrin alpha V decreases expression ISO rebaudioside A results in decreased expression of ITGAV mRNA CTD PMID:31655124 NCBI chr 2:83,722,303...83,806,917
Ensembl chr 2:83,724,397...83,806,916
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO rebaudioside A results in decreased expression of KIT mRNA CTD PMID:31655124 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Lep leptin multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lipc lipase, hepatic multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] CTD PMID:25554529 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO rebaudioside A results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] CTD PMID:25554529 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] CTD PMID:25554529 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] CTD PMID:25554529 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] CTD PMID:25554529 NCBI chr 2:173,153,073...173,159,274
Ensembl chr 2:173,153,048...173,159,273
JBrowse link
G Pf4 platelet factor 4 increases expression ISO rebaudioside A results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr 5:90,772,435...90,773,383
Ensembl chr 5:90,772,435...90,773,383
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] CTD PMID:25554529 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] CTD PMID:25554529 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] CTD PMID:25554529 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] CTD PMID:25554529 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rebaudioside A results in decreased expression of PTGS2 mRNA CTD PMID:31655124 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA] CTD PMID:25554529 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Sele selectin, endothelial cell decreases expression ISO rebaudioside A results in decreased expression of SELE mRNA CTD PMID:31655124 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] CTD PMID:25554529 NCBI chr 8:71,568,728...71,587,307
Ensembl chr 8:71,568,882...71,587,302
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] CTD PMID:25554529 NCBI chr 3:28,697,903...28,728,361
Ensembl chr 3:28,697,903...28,731,359
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 decreases expression ISO rebaudioside A results in decreased expression of TNFSF10 mRNA CTD PMID:31655124 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
stevioside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 decreases expression ISO stevioside results in decreased expression of ACE mRNA CTD PMID:31655124 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:20871768 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] CTD PMID:25554529 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases secretion ISO stevioside results in decreased secretion of ACP5 protein CTD PMID:21089163 NCBI chr 9:22,126,727...22,135,746
Ensembl chr 9:22,126,727...22,135,711
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression ISO stevioside results in increased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO stevioside results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Bax BCL2-associated X protein decreases expression ISO stevioside results in decreased expression of BAX mRNA CTD PMID:31655124 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha increases expression ISO stevioside results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Cat catalase multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] CTD PMID:25554529 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO stevioside results in decreased expression of CCL2 mRNA CTD PMID:31655124 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO stevioside results in decreased expression of CFLAR mRNA CTD PMID:31655124 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] CTD PMID:25554529 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO stevioside results in increased expression of CYP1A1 mRNA CTD PMID:28887089 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO stevioside results in increased expression of CYP1A2 mRNA; stevioside results in increased expression of CYP1A2 protein CTD PMID:28887089 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO stevioside results in increased expression of CYP1B1 mRNA CTD PMID:28887089 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases expression ISO stevioside results in decreased expression of CYP2C9 mRNA CTD PMID:28887089 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases expression ISO stevioside results in decreased expression of CYP2C9 mRNA CTD PMID:28887089 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
increases expression
ISO stevioside binds to and results in decreased activity of CYP3A4 protein
stevioside results in increased expression of CYP3A4 mRNA; stevioside results in increased expression of CYP3A4 protein
CTD PMID:28887089 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] CTD PMID:25554529 NCBI chr 7:99,153,663...99,182,713
Ensembl chr 7:99,153,658...99,182,719
JBrowse link
G Edn1 endothelin 1 decreases expression ISO stevioside results in decreased expression of EDN1 mRNA CTD PMID:31655124 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednra endothelin receptor type A increases expression ISO stevioside results in increased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO stevioside results in decreased expression of F2R mRNA CTD PMID:31655124 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO stevioside results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO stevioside results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:38,838,672...38,929,470
Ensembl chr18:38,838,673...38,929,472
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 decreases expression ISO stevioside results in decreased expression of FLT1 mRNA CTD PMID:31655124 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] CTD PMID:25554529 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G G6pc glucose-6-phosphatase, catalytic multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA] CTD PMID:25554529 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G Insr insulin receptor multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] CTD PMID:25554529 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 NCBI chr 8:10,984,681...11,008,929
Ensembl chr 8:10,984,681...11,008,458
JBrowse link
G Itgav integrin alpha V decreases expression ISO stevioside results in decreased expression of ITGAV mRNA CTD PMID:31655124 NCBI chr 2:83,722,303...83,806,917
Ensembl chr 2:83,724,397...83,806,916
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO stevioside results in decreased expression of KIT mRNA CTD PMID:31655124 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Lep leptin multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lipc lipase, hepatic multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] CTD PMID:25554529 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO stevioside results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] CTD PMID:25554529 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] CTD PMID:25554529 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] CTD PMID:25554529 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] CTD PMID:25554529 NCBI chr 2:173,153,073...173,159,274
Ensembl chr 2:173,153,048...173,159,273
JBrowse link
G Pf4 platelet factor 4 increases expression ISO stevioside results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr 5:90,772,435...90,773,383
Ensembl chr 5:90,772,435...90,773,383
JBrowse link
G Plin2 perilipin 2 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA] CTD PMID:25554529 NCBI chr 4:86,626,910...86,670,217
Ensembl chr 4:86,648,386...86,670,060
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] CTD PMID:25554529 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] CTD PMID:25554529 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] CTD PMID:25554529 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] CTD PMID:25554529 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO stevioside results in decreased expression of PTGS2 mRNA CTD PMID:31655124 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA] CTD PMID:25554529 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Sele selectin, endothelial cell decreases expression ISO stevioside results in decreased expression of SELE mRNA CTD PMID:31655124 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] CTD PMID:25554529 NCBI chr 8:71,568,728...71,587,307
Ensembl chr 8:71,568,882...71,587,302
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] CTD PMID:25554529 NCBI chr 3:28,697,903...28,728,361
Ensembl chr 3:28,697,903...28,731,359
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 decreases expression ISO stevioside results in decreased expression of TNFSF10 mRNA CTD PMID:31655124 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21475
    chemical entity 21474
      atom 21460
        nonmetal atom 21337
          carbon atom 21046
            organic molecular entity 21046
              isoprenoid 9799
                terpenoid 9782
                  diterpenoid 8615
                    diterpene glycoside 55
                      (2R,3R,4S,5S,6R)-2-[[7-[[(2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]oxy]-2-ethenyl-2,4b,8,8-tetramethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol 0
                      16-alpha-D-mannopyranosyloxyisopimar-7-en-19-oic acid 0
                      6'-de-O-acetylcupacinoside 0
                      A28086B 0
                      LSM-5186 0
                      Phaseoloside D 0
                      Saikosaponin BK1 0
                      attenoside 0
                      cupacinoside 0
                      eichlerianic acid 0
                      fischeroside A 0
                      fischeroside B 0
                      fischeroside C 0
                      forskoditerpenoside C 0
                      forskoditerpenoside D 0
                      forskoditerpenoside E 0
                      lyciumoside II 0
                      lyciumoside IV + 0
                      nicotianoside I 0
                      nicotianoside II 0
                      rebaudioside B(1-) 0
                      steviol glycoside + 55
                      steviolbioside 0
                      steviolmonoside + 0
                      stevioside + 54
Path 2
Term Annotations click to browse term
  CHEBI ontology 21475
    subatomic particle 21460
      composite particle 21460
        hadron 21460
          baryon 21460
            nucleon 21460
              atomic nucleus 21460
                atom 21460
                  main group element atom 21361
                    p-block element atom 21361
                      carbon group element atom 21148
                        carbon atom 21046
                          organic molecular entity 21046
                            heteroorganic entity 20684
                              organochalcogen compound 19891
                                organooxygen compound 19817
                                  carbohydrates and carbohydrate derivatives 12743
                                    carbohydrate 12743
                                      carbohydrate derivative 12369
                                        glycosyl compound 11081
                                          glycoside 9377
                                            terpene glycoside 372
                                              diterpene glycoside 55
                                                (2R,3R,4S,5S,6R)-2-[[7-[[(2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]oxy]-2-ethenyl-2,4b,8,8-tetramethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol 0
                                                16-alpha-D-mannopyranosyloxyisopimar-7-en-19-oic acid 0
                                                6'-de-O-acetylcupacinoside 0
                                                A28086B 0
                                                LSM-5186 0
                                                Phaseoloside D 0
                                                Saikosaponin BK1 0
                                                attenoside 0
                                                cupacinoside 0
                                                eichlerianic acid 0
                                                fischeroside A 0
                                                fischeroside B 0
                                                fischeroside C 0
                                                forskoditerpenoside C 0
                                                forskoditerpenoside D 0
                                                forskoditerpenoside E 0
                                                lyciumoside II 0
                                                lyciumoside IV + 0
                                                nicotianoside I 0
                                                nicotianoside II 0
                                                rebaudioside B(1-) 0
                                                steviol glycoside + 55
                                                steviolbioside 0
                                                steviolmonoside + 0
                                                stevioside + 54
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.