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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxybenzoquinone
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Accession:CHEBI:71648 term browser browse the term
Definition:Benzoquinones with at least one hydroxy substituent.
Synonyms:related_synonym: hydroxybenzoquinones



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coenzyme Q10 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein] CTD PMID:27087047 PMID:27345130 PMID:32383521 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein CTD PMID:33754447 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:22186599 PMID:32383521 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA] CTD PMID:21370964 NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:27087047 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein] CTD PMID:27087047 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein
CTD PMID:27087047 PMID:33393703 PMID:33754447 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP
ISO
coenzyme Q10 results in increased expression of BCL2 mRNA
[coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
CTD PMID:18817789 PMID:27087047 PMID:33393703 PMID:33754447 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:27087047 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G C1qa complement C1q A chain decreases expression ISO coenzyme Q10 results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO coenzyme Q10 results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:20510337 PMID:22186599 PMID:27087047 PMID:33393703 PMID:33754447 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein] CTD PMID:27087047 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:27087047 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]
[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of CAT mRNA]
CTD PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] CTD PMID:27087047 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein] CTD PMID:27087047 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Ctss cathepsin S decreases expression ISO coenzyme Q10 results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein] CTD PMID:23640862 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA] CTD PMID:21370964 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
JBrowse link
G Etv3 ETS variant transcription factor 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA] CTD PMID:21370964 NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314
JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein] CTD PMID:27087047 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Faslg Fas ligand multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein] CTD PMID:27087047 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of G6PD protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein] CTD PMID:33548410 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO coenzyme Q10 results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased activity of GPT protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]
CTD PMID:27174133 PMID:33271250 PMID:33393703 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA] CTD PMID:33271250 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein] CTD PMID:22186599 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:19958828 PMID:33393703 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA] CTD PMID:27174133 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] CTD PMID:32383521 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10 CTD PMID:15256069 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions
increases activity
EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
coenzyme Q10 results in increased activity of LDHC protein
CTD PMID:33548410 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:27087047 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:27087047 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA] CTD PMID:21370964 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 increases expression
multiple interactions
ISO coenzyme Q10 results in increased expression of NDUFB6 protein
coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]
CTD PMID:19523936 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO coenzyme Q10 results in increased expression of NDUFS7 protein CTD PMID:19523936 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein] CTD PMID:33754447 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO
coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]
CTD PMID:27174133 PMID:33271250 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:20510337 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein] CTD PMID:23640862 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Oscar osteoclast associated Ig-like receptor multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein] CTD PMID:33754447 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO coenzyme Q10 results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA] CTD PMID:31557371 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] CTD PMID:22186599 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein] CTD PMID:33271250 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA] CTD PMID:21370964 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA] CTD PMID:21370964 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein] CTD PMID:33271250 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA] CTD PMID:21370964 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO coenzyme Q10 results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snca synuclein alpha multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]
[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein
CTD PMID:15114628 PMID:19476553 PMID:21843543 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod2 superoxide dismutase 2 affects expression
multiple interactions
EXP
ISO
coenzyme Q10 affects the expression of SOD2 protein
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA]
coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]
CTD PMID:22083459 PMID:24008411 PMID:33271250 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:33271250 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA] CTD PMID:27087047 PMID:27174133 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]
CTD PMID:20510337 PMID:32383521 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] CTD PMID:33754447 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased phosphorylation of TP53 protein]
CTD PMID:20510337 PMID:33393703 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] CTD PMID:33754447 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
embelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO embelin results in decreased phosphorylation of AKT1 protein CTD PMID:24694877 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO embelin results in increased expression of BAX protein CTD PMID:24694877 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO embelin results in decreased expression of BCL2 protein CTD PMID:24694877 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression ISO embelin results in increased expression of BECN1 protein CTD PMID:28722333 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases degradation
ISO embelin results in increased cleavage of CASP3 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases degradation
multiple interactions
ISO embelin results in increased degradation of CASP9 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]
CTD PMID:28722333 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein] CTD PMID:32020686 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO embelin results in decreased expression of CCND1 protein CTD PMID:24694877 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 increases expression ISO embelin results in increased expression of CDH1 protein CTD PMID:24694877 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO embelin results in decreased expression of CDK2 protein CTD PMID:24694877 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO embelin results in decreased expression of CDK6 protein CTD PMID:24694877 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO embelin results in increased cleavage of DFFA protein CTD PMID:28722333 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO embelin results in decreased expression of GLI1 protein CTD PMID:24694877 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO embelin results in decreased expression of GLI2 protein CTD PMID:24694877 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:32020686 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:32020686 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO embelin results in decreased expression of KDR protein CTD PMID:24694877 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO embelin results in decreased expression of MKI67 protein CTD PMID:24694877 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO embelin results in decreased expression of MMP2 protein CTD PMID:24694877 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO embelin results in decreased expression of MMP9 protein CTD PMID:24694877 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO embelin results in increased cleavage of PARP1 protein
3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO embelin results in decreased expression of PCNA protein CTD PMID:24694877 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO embelin results in decreased expression of PTGS2 protein CTD PMID:24694877 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein] CTD PMID:32020686 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO embelin results in decreased expression of SNAI1 protein CTD PMID:24694877 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO embelin results in decreased expression of SNAI2 protein CTD PMID:24694877 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO embelin results in increased degradation of SQSTM1 protein CTD PMID:28722333 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:32020686 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO embelin results in increased expression of TNFRSF10A protein CTD PMID:24694877 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO embelin results in decreased expression of VEGFA protein CTD PMID:24694877 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases activity
increases degradation
ISO embelin results in decreased activity of XIAP protein
embelin results in increased degradation of XIAP protein
CTD PMID:16339139 PMID:28722333 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO embelin results in decreased expression of ZEB1 protein CTD PMID:24694877 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
Ilimaquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ilimaquinone results in decreased expression of BCL2 protein CTD PMID:24930757 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO ilimaquinone results in decreased expression of BCL2L1 protein CTD PMID:24930757 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
ilimaquinone results in increased cleavage of CASP3 protein
CTD PMID:24930757 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO ilimaquinone results in increased cleavage of CASP8 protein CTD PMID:24930757 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA] CTD PMID:24930757 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK1 protein CTD PMID:24930757 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK3 protein CTD PMID:24930757 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
ilimaquinone results in increased cleavage of PARP1 protein
CTD PMID:24930757 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pld2 phospholipase D2 multiple interactions
increases activity
ISO 1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein] CTD PMID:17897952 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]
ilimaquinone results in increased expression of TNFRSF10A mRNA; ilimaquinone results in increased expression of TNFRSF10A protein
CTD PMID:24930757 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:24930757 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
ubiquinone-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q1 CTD PMID:20399199 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
ubiquinone-9 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of ubiquinone 9 CTD PMID:15256069 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
ubiquinones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions EXP Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:20584200 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO ubiquinones decrease 4-hydroxynonenal-Aldh2 protein adduct formation; decrease acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver RGD PMID:29156373 RGD:15036805 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Casp3 caspase 3 multiple interactions ISO Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA] CTD PMID:12880480 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases activity EXP Ubiquinone results in increased activity of CAT protein CTD PMID:20034476 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Coq8a coenzyme Q8A increases chemical synthesis ISO COQ8A protein results in increased chemical synthesis of Ubiquinone CTD PMID:18319072 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
increases metabolic processing
ISO
EXP
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
DHODH protein results in increased metabolism of Ubiquinone
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
CTD PMID:9802339 PMID:11248707 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein] CTD PMID:17516992 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein] CTD PMID:17516992 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3] CTD PMID:20020783 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein CTD PMID:18377693 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein affects the reaction [Diethylhexyl Phthalate affects the abundance of Ubiquinone] CTD PMID:10731415 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein] CTD PMID:17516992 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases reduction
decreases oxidation
ISO XRCC1 gene mutant form results in decreased reduction of Ubiquinone
XRCC1 results in decreased oxidation of Ubiquinone
CTD PMID:30998386 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          heteroatomic molecular entity 19662
            hydroxides 19158
              organic hydroxy compound 18656
                hydroxyquinone 193
                  hydroxybenzoquinone 97
                    dihydroxy-1,4-benzoquinones + 34
                    monohydroxy-1,4-benzoquinones + 78
                    tetrahydroxy-1,4-benzoquinone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      ketone 16957
                                        cyclic ketone 15522
                                          quinone 8385
                                            hydroxyquinone 193
                                              hydroxybenzoquinone 97
                                                dihydroxy-1,4-benzoquinones + 34
                                                monohydroxy-1,4-benzoquinones + 78
                                                tetrahydroxy-1,4-benzoquinone + 0
paths to the root