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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PPARgamma agonist
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Accession:CHEBI:71554 term browser browse the term
Definition:A PPAR modulator which activates the peroxisome proliferator-activated receptor-gamma.
Synonyms:related_synonym: PPAR-gamma agonist;   PPAR-gamma agonists;   PPARgamma agonists;   peroxisome proliferator-activated receptor-gamma agonist;   peroxisome proliferator-activated receptor-gamma agonists


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monascin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]] CTD PMID:23331247 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glo1 glyoxalase 1 increases expression ISO monascin results in increased expression of GLO1 protein CTD PMID:23954466 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]] CTD PMID:23331247 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]]
monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]
CTD PMID:23331247, PMID:23954466 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO monascin inhibits the reaction [Ovalbumin results in increased expression of IL6 mRNA]; monascin inhibits the reaction [Ovalbumin results in increased expression of IL6 protein]; monascin inhibits the reaction [Ovalbumin results in increased secretion of IL6 protein] CTD PMID:22381257 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO monascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein] CTD PMID:23331247 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO monascin inhibits the reaction [S100B protein results in increased expression of and affects the localization of NCF1 protein] CTD PMID:23331247 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
increases expression
multiple interactions
increases phosphorylation
ISO
EXP
monascin affects the localization of NFE2L2 protein
monascin results in increased expression of NFE2L2 mRNA
2-chloro-5-nitrobenzanilide inhibits the reaction [monascin results in increased expression of NFE2L2 mRNA]; PPARG mutant form inhibits the reaction [monascin results in increased expression of NFE2L2 mRNA]
monascin results in increased phosphorylation of NFE2L2 protein
monascin inhibits the reaction [S100B protein results in decreased expression of NFE2L2 protein]; monascin promotes the reaction [S100B protein affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]]
CTD PMID:23331247, PMID:23954466 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO monascin inhibits the reaction [Ovalbumin results in increased expression of NOS2 protein] CTD PMID:22381257 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression ISO monascin results in increased expression of NR1H4 mRNA CTD PMID:24275089 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Tretinoin inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]] CTD PMID:23331247 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
ISO monascin affects the reaction [PPARA protein affects the oxidation of Fatty Acids]; monascin binds to and results in increased activity of PPARA protein
monascin results in increased expression of PPARA mRNA
CTD PMID:24275089 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects localization
increases response to substance
multiple interactions
increases expression
decreases phosphorylation
ISO
EXP
monascin affects the localization of PPARG protein
PPARG protein results in increased susceptibility to monascin
PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [monascin results in increased expression of NFE2L2 mRNA]
monascin results in increased expression of PPARG protein
monascin results in decreased phosphorylation of PPARG protein
CTD PMID:22381257, PMID:23954466 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO monascin results in increased expression of PPARGC1A mRNA CTD PMID:24275089 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO monascin inhibits the reaction [Ovalbumin results in increased expression of PTGS2 protein] CTD PMID:22381257 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]; monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]; monascin inhibits the reaction [S100B protein results in decreased expression of NFE2L2 protein]; monascin inhibits the reaction [S100B protein results in increased expression of and affects the localization of NCF1 protein]; monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]; monascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein]; monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]; monascin promotes the reaction [S100B protein affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]] CTD PMID:23331247 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
monascin inhibits the reaction [[Ovalbumin co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of TNF protein]; monascin inhibits the reaction [[Ovalbumin co-treated with MK-886] results in increased expression of TNF protein]; monascin inhibits the reaction [Ovalbumin results in increased expression of TNF mRNA]; monascin inhibits the reaction [Ovalbumin results in increased expression of TNF protein]; monascin inhibits the reaction [Ovalbumin results in increased secretion of TNF protein]; monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]; NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]]
monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]
CTD PMID:22381257, PMID:23331247, PMID:23954466 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      biological role 19746
        pharmacological role 18825
          PPAR modulator 3871
            PPARgamma agonist 17
              (4Z,7Z,10Z,13Z,15E,19Z)-17-oxodocosahexaenoic acid 0
              (5Z,8Z,11Z,14Z,17Z)-icosapentaenoylethanolamine 0
              1-O-hexadecyl-2-(8-carboxyoctanoyl)-sn-glycero-3-phosphocholine 0
              2-hydroxylinoleic acid 0
              4',6,7-trihydroxyisoflavone 0
              monascin 17
              protectin D1 + 0
              saroglitazar 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.