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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triamcinolone acetonide
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Accession:CHEBI:71418 term browser browse the term
Definition:A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.
Synonyms:exact_synonym: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
 related_synonym: (11beta,16alpha)-9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;   9-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;   9alpha-fluoro-11beta,21-dihydroxy-16alpha,17-isopropylidenedioxy-1,4-pregnadiene,3,20-dione;   9alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione;   9alpha-fluoro-16alpha-17alpha-isopropyledenedioxyprednisolone;   9alpha-fluoro-16alpha-17alpha-isopropylidenedioxy-Delta-1-hydrocortisone;   9alpha-fluoro-16alpha-hydroxyprednisolone 16alpha,17alpha-acetonide;   Formula=C24H31FO6;   InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1;   InChIKey=YNDXUCZADRHECN-JNQJZLCISA-N;   SMILES=[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   Triamcinolone 16,17-acetonide
 alt_id: CHEBI:9668
 xref: CAS:76-25-5;   DrugBank:DB00620;   Drug_Central:2726;   KEGG:C08183;   KEGG:D00983
 xref_mesh: MESH:D014222
 xref: Patent:US2008118586;   Patent:US2008139545;   Reaxys:60069;   VSDB:3009;   Wikipedia:Triamcinolone_acetonide



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triamcinolone acetonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of Triamcinolone Acetonide CTD PMID:16105236 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Triamcinolone Acetonide results in increased expression of BAD protein CTD PMID:15987869 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Triamcinolone Acetonide results in increased expression of BAX protein CTD PMID:15987869 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Triamcinolone Acetonide results in increased expression of BID protein CTD PMID:15987869 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp8 caspase 8 increases activity EXP Triamcinolone Acetonide results in increased activity of CASP8 protein CTD PMID:15987869 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:10903220 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Triamcinolone Acetonide promotes the reaction [Paraquat results in increased expression of CCN2 mRNA] CTD PMID:15728566 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases secretion
ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Triamcinolone Acetonide results in decreased secretion of CSF2 protein
CTD PMID:10460758 PMID:10868704 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Triamcinolone Acetonide results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions
ISO Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA
Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]
CTD PMID:24555085 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Fadd Fas associated via death domain increases expression EXP Triamcinolone Acetonide results in increased expression of FADD protein CTD PMID:15987869 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased abundance of Thromboxane B2]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10460758 PMID:15337628 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA] CTD PMID:27916735 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Triamcinolone Acetonide results in decreased expression of MKI67 protein CTD PMID:16029572 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA] CTD PMID:27916735 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
decreases expression
ISO
EXP
[Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide binds to and affects the localization of NR3C1 protein
Triamcinolone Acetonide analog binds to NR3C1 protein; Triamcinolone Acetonide binds to NR3C1 protein
Triamcinolone Acetonide results in decreased expression of NR3C1 protein
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]; Triamcinolone Acetonide binds to and affects the activity of NR3C1 protein
CTD PMID:926113 PMID:15250541 PMID:15705660 PMID:15976447 PMID:16029572 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases activity ISO Triamcinolone Acetonide results in decreased activity of PLA2G4A protein CTD PMID:15337628 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO
Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form
CTD PMID:25447644 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Triamcinolone Acetonide results in increased expression of SULT1A1 mRNA; Triamcinolone Acetonide results in increased expression of SULT1A1 protein CTD PMID:10799342 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:15728566 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]
CTD PMID:10100995 PMID:10903220 PMID:15337628 PMID:27916735 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA]
Triamcinolone Acetonide results in decreased expression of VEGFA protein
CTD PMID:15728566 PMID:16029572 PMID:16249516 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        anti-inflammatory agent 16531
          anti-inflammatory drug 14962
            triamcinolone acetonide 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      ketone 17210
                                        oxyketone 8903
                                          alpha-oxyketone 8903
                                            alpha-hydroxy ketone 8903
                                              primary alpha-hydroxy ketone 7794
                                                triamcinolone 37
                                                  triamcinolone acetonide 24
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