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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triamcinolone acetonide
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Accession:CHEBI:71418 term browser browse the term
Definition:A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.
Synonyms:exact_synonym: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
 related_synonym: (11beta,16alpha)-9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;   9-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;   9alpha-fluoro-11beta,21-dihydroxy-16alpha,17-isopropylidenedioxy-1,4-pregnadiene,3,20-dione;   9alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione;   9alpha-fluoro-16alpha-17alpha-isopropyledenedioxyprednisolone;   9alpha-fluoro-16alpha-17alpha-isopropylidenedioxy-Delta-1-hydrocortisone;   9alpha-fluoro-16alpha-hydroxyprednisolone 16alpha,17alpha-acetonide;   Formula=C24H31FO6;   InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1;   InChIKey=YNDXUCZADRHECN-JNQJZLCISA-N;   SMILES=[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   Triamcinolone 16,17-acetonide
 alt_id: CHEBI:9668
 xref: CAS:76-25-5;   DrugBank:DB00620;   Drug_Central:2726;   KEGG:C08183;   KEGG:D00983
 xref_mesh: MESH:D014222
 xref: Patent:US2008118586;   Patent:US2008139545;   Reaxys:60069;   VSDB:3009;   Wikipedia:Triamcinolone_acetonide


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triamcinolone acetonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of Triamcinolone Acetonide CTD PMID:16105236 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein] CTD PMID:23751068 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Triamcinolone Acetonide results in increased expression of BAD protein CTD PMID:15987869 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Triamcinolone Acetonide results in increased expression of BAX protein CTD PMID:15987869 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Triamcinolone Acetonide results in increased expression of BID protein CTD PMID:15987869 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp8 caspase 8 increases activity EXP Triamcinolone Acetonide results in increased activity of CASP8 protein CTD PMID:15987869 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:10903220 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Triamcinolone Acetonide promotes the reaction [Paraquat results in increased expression of CCN2 mRNA] CTD PMID:15728566 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases secretion
ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Triamcinolone Acetonide results in decreased secretion of CSF2 protein
CTD PMID:10460758 PMID:10868704 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Triamcinolone Acetonide results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions
ISO Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA
Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]
CTD PMID:24555085 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Fadd Fas associated via death domain increases expression EXP Triamcinolone Acetonide results in increased expression of FADD protein CTD PMID:15987869 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased abundance of Thromboxane B2]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10460758 PMID:15337628 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of IL4 mRNA] CTD PMID:23751068 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of IL5 mRNA] CTD PMID:23751068 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA] CTD PMID:27916735 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA] CTD PMID:23751068 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Triamcinolone Acetonide results in decreased expression of MKI67 protein CTD PMID:16029572 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA] CTD PMID:27916735 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
decreases expression
ISO
EXP
[Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide binds to and affects the localization of NR3C1 protein
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]; Triamcinolone Acetonide binds to and affects the activity of NR3C1 protein
Triamcinolone Acetonide results in decreased expression of NR3C1 protein
Triamcinolone Acetonide analog binds to NR3C1 protein; Triamcinolone Acetonide binds to NR3C1 protein
CTD PMID:926113 PMID:15250541 PMID:15705660 PMID:15976447 PMID:16029572 PMID:16507850 PMID:23765520 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases activity ISO Triamcinolone Acetonide results in decreased activity of PLA2G4A protein CTD PMID:15337628 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of PTGS2 protein] CTD PMID:23751068 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO
Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form
CTD PMID:25447644 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Triamcinolone Acetonide results in increased expression of SULT1A1 mRNA; Triamcinolone Acetonide results in increased expression of SULT1A1 protein CTD PMID:10799342 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:15728566 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]
CTD PMID:10100995 PMID:10903220 PMID:15337628 PMID:27916735 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA]
Triamcinolone Acetonide results in decreased expression of VEGFA protein
CTD PMID:15728566 PMID:16029572 PMID:16249516 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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  CHEBI ontology 19840
    role 19790
      application 19464
        anti-inflammatory agent 14968
          anti-inflammatory drug 13619
            triamcinolone acetonide 29
Path 2
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  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16187
                                        oxyketone 8646
                                          alpha-oxyketone 8646
                                            alpha-hydroxy ketone 8646
                                              primary alpha-hydroxy ketone 7526
                                                triamcinolone 42
                                                  triamcinolone acetonide 29
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