Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:procarbazine
go back to main search page
Accession:CHEBI:71417 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Synonyms:related_synonym: 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine;   2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine;   4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide;   Formula=C12H19N3O;   InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);   InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N;   N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide;   N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine;   N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide;   N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide;   N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide;   Procarbazin;   SMILES=CNNCc1ccc(cc1)C(=O)NC(C)C;   p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide;   procarbazina;   procarbazinum
 alt_id: CHEBI:8432
 xref: CAS:671-16-9;   DrugBank:DB01168;   Drug_Central:2272;   HMDB:HMDB0015299;   KEGG:C07402;   KEGG:D08423;   LINCS:LSM-2272
 xref_mesh: MESH:D011344
 xref: PMID:21420247;   PMID:21703849;   PMID:21740300;   PMID:21870118;   PMID:22423248;   PMID:22708037;   PMID:22744756;   PMID:22851558;   PMID:22913972;   PMID:23071237;   Patent:BE618638;   Patent:US2007122414;   Patent:US2008107661;   Patent:US3520926;   Patent:US3830840;   Reaxys:958270;   Wikipedia:Procarbazine
 cyclic_relationship: is_conjugate_base_of CHEBI:71431

show annotations for term's descendants           Sort by:
 
procarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc3 amine oxidase, copper containing 3 decreases activity EXP Procarbazine results in decreased activity of AOC3 protein CTD PMID:8583353 NCBI chr10:89,251,370...89,259,313
Ensembl chr10:89,251,370...89,259,313 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions ISO INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:21246521 NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431 		JBrowse link
G Ldha lactate dehydrogenase A increases mutagenesis ISO Procarbazine results in increased mutagenesis of LDHA gene CTD PMID:7534515 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707 		JBrowse link
G Maoa monoamine oxidase A increases activity EXP Procarbazine results in increased activity of MAOA protein CTD PMID:8583353 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]; MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:16033832 PMID:16936459 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Prm1 protamine 1 decreases expression EXP Procarbazine results in decreased expression of PRM1 mRNA CTD PMID:8226304 NCBI chr10:4,945,995...4,946,241
Ensembl chr10:4,945,911...4,946,397 		JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO Procarbazine results in increased mutagenesis of TK1 gene CTD PMID:3288842 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pharmaceutical 19338
          drug 19338
            antineoplastic agent 17009
              procarbazine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        carboacyl group 17377
                                          univalent carboacyl group 17377
                                            carbamoyl group 17164
                                              carboxamide 17164
                                                monocarboxylic acid amide 14583
                                                  arenecarboxamide 6520
                                                    benzamides 6520
                                                      procarbazine 7
paths to the root