CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: procarbazine
Accession: CHEBI:71417
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Definition: A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Synonyms: related_synonym: 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine; 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine; 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide; Formula=C12H19N3O; InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16); InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N; N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide; N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine; N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide; N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide; N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide; Procarbazin; SMILES=CNNCc1ccc(cc1)C(=O)NC(C)C; p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide; procarbazina; procarbazinum
alt_id: CHEBI:8432
xref: CAS:671-16-9; DrugBank:DB01168; Drug_Central:2272; HMDB:HMDB0015299; KEGG:C07402; KEGG:D08423; LINCS:LSM-2272
xref_mesh: MESH:D011344
xref: PMID:21420247; PMID:21703849; PMID:21740300; PMID:21870118; PMID:22423248; PMID:22708037; PMID:22744756; PMID:22851558; PMID:22913972; PMID:23071237; Patent:BE618638; Patent:US2007122414; Patent:US2008107661; Patent:US3520926; Patent:US3830840; Reaxys:958270; Wikipedia:Procarbazine
cyclic_relationship: is_conjugate_base_of CHEBI:71431
G
Aoc3
amine oxidase, copper containing 3
decreases activity
EXP
Procarbazine results in decreased activity of AOC3 protein
CTD
PMID:8583353
NCBI chr10:86,272,757...86,280,702
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Procarbazine results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Ina
internexin neuronal intermediate filament protein, alpha
multiple interactions
ISO
INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]
CTD
PMID:21246521
NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
G
Ldha
lactate dehydrogenase A
increases mutagenesis
ISO
Procarbazine results in increased mutagenesis of LDHA gene
CTD
PMID:7534515
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
G
Maoa
monoamine oxidase A
increases activity
EXP
Procarbazine results in increased activity of MAOA protein
CTD
PMID:8583353
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
G
Mgmt
O-6-methylguanine-DNA methyltransferase
multiple interactions
ISO
MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]; MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]
CTD
PMID:16033832 PMID:16936459
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
G
Prm1
protamine 1
decreases expression
EXP
Procarbazine results in decreased expression of PRM1 mRNA
CTD
PMID:8226304
NCBI chr10:4,871,909...4,872,155
G
Tk1
thymidine kinase 1
increases mutagenesis
ISO
Procarbazine results in increased mutagenesis of TK1 gene
CTD
PMID:3288842
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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