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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:procarbazine
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Accession:CHEBI:71417 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Synonyms:related_synonym: 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine;   2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine;   4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide;   Formula=C12H19N3O;   InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);   InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N;   N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide;   N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine;   N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide;   N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide;   N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide;   Procarbazin;   SMILES=CNNCc1ccc(cc1)C(=O)NC(C)C;   p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide;   procarbazina;   procarbazinum
 alt_id: CHEBI:8432
 xref: CAS:671-16-9;   DrugBank:DB01168;   Drug_Central:2272;   HMDB:HMDB0015299;   KEGG:C07402;   KEGG:D08423;   LINCS:LSM-2272
 xref_mesh: MESH:D011344
 xref: PMID:21420247;   PMID:21703849;   PMID:21740300;   PMID:21870118;   PMID:22423248;   PMID:22708037;   PMID:22744756;   PMID:22851558;   PMID:22913972;   PMID:23071237;   Patent:BE618638;   Patent:US2007122414;   Patent:US2008107661;   Patent:US3520926;   Patent:US3830840;   Reaxys:958270;   Wikipedia:Procarbazine
 cyclic_relationship: is_conjugate_base_of CHEBI:71431



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procarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc3 amine oxidase, copper containing 3 decreases activity EXP Procarbazine results in decreased activity of AOC3 protein CTD PMID:8583353 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Procarbazine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions ISO INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:21246521 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
JBrowse link
G Ldha lactate dehydrogenase A increases mutagenesis ISO Procarbazine results in increased mutagenesis of LDHA gene CTD PMID:7534515 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Maoa monoamine oxidase A increases activity EXP Procarbazine results in increased activity of MAOA protein CTD PMID:8583353 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]; MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:16033832 PMID:16936459 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Prm1 protamine 1 decreases expression EXP Procarbazine results in decreased expression of PRM1 mRNA CTD PMID:8226304 NCBI chr10:4,871,817...4,872,312 JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO Procarbazine results in increased mutagenesis of TK1 gene CTD PMID:3288842 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      application 19679
        pharmaceutical 19495
          drug 19520
            antineoplastic agent 17820
              procarbazine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            heteroorganic entity 19474
                              organochalcogen compound 19262
                                organooxygen compound 19153
                                  carbon oxoacid 18647
                                    carboxylic acid 18620
                                      carboacyl group 17681
                                        univalent carboacyl group 17681
                                          carbamoyl group 17551
                                            carboxamide 17551
                                              monocarboxylic acid amide 15669
                                                arenecarboxamide 8259
                                                  benzamides 8255
                                                    procarbazine 8
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