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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:procarbazine
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Accession:CHEBI:71417 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Synonyms:related_synonym: 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine;   2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine;   4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide;   Formula=C12H19N3O;   InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);   InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N;   N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide;   N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine;   N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide;   N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide;   N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide;   Procarbazin;   SMILES=CNNCc1ccc(cc1)C(=O)NC(C)C;   p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide;   procarbazina;   procarbazinum
 alt_id: CHEBI:8432
 xref: CAS:671-16-9;   DrugBank:DB01168;   Drug_Central:2272;   HMDB:HMDB0015299;   KEGG:C07402;   KEGG:D08423;   LINCS:LSM-2272
 xref_mesh: MESH:D011344
 xref: PMID:21420247;   PMID:21703849;   PMID:21740300;   PMID:21870118;   PMID:22423248;   PMID:22708037;   PMID:22744756;   PMID:22851558;   PMID:22913972;   PMID:23071237;   Patent:BE618638;   Patent:US2007122414;   Patent:US2008107661;   Patent:US3520926;   Patent:US3830840;   Reaxys:958270;   Wikipedia:Procarbazine
 cyclic_relationship: is_conjugate_base_of CHEBI:71431


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procarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc3 amine oxidase, copper containing 3 decreases activity EXP Procarbazine results in decreased activity of AOC3 protein CTD PMID:8583353 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Procarbazine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions ISO INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:21246521 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330 		JBrowse link
G Ldha lactate dehydrogenase A increases mutagenesis ISO Procarbazine results in increased mutagenesis of LDHA gene CTD PMID:7534515 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Maoa monoamine oxidase A increases activity EXP Procarbazine results in increased activity of MAOA protein CTD PMID:8583353 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]; MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:16033832 PMID:16936459 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Prm1 protamine 1 decreases expression EXP Procarbazine results in decreased expression of PRM1 mRNA CTD PMID:8226304 NCBI chr10:4,871,909...4,872,155 JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO Procarbazine results in increased mutagenesis of TK1 gene CTD PMID:3288842 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      application 19546
        pharmaceutical 19425
          drug 19425
            antineoplastic agent 17627
              procarbazine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        carboacyl group 17656
                                          univalent carboacyl group 17656
                                            carbamoyl group 17497
                                              carboxamide 17497
                                                monocarboxylic acid amide 15562
                                                  arenecarboxamide 7310
                                                    benzamides 7310
                                                      procarbazine 8
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