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ONTOLOGY REPORT - ANNOTATIONS
Term:procarbazine
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Accession:CHEBI:71417 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Synonyms:related_synonym: 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine;   2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine;   4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide;   Formula=C12H19N3O;   InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);   InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N;   N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide;   N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine;   N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide;   N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide;   N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide;   Procarbazin;   SMILES=CNNCc1ccc(cc1)C(=O)NC(C)C;   p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide;   procarbazina;   procarbazinum
 alt_id: CHEBI:8432
 xref: CAS:671-16-9 "ChemIDplus";   CAS:671-16-9 "KEGG COMPOUND";   CAS:671-16-9 "NIST Chemistry WebBook";   DrugBank:DB01168;   Drug_Central:2272 "DrugCentral";   HMDB:HMDB0015299;   KEGG:C07402;   KEGG:D08423;   LINCS:LSM-2272
 xref_mesh: MESH:D011344
 xref: PMID:21420247 "Europe PMC";   PMID:21703849 "Europe PMC";   PMID:21740300 "Europe PMC";   PMID:21870118 "Europe PMC";   PMID:22423248 "Europe PMC";   PMID:22708037 "Europe PMC";   PMID:22744756 "Europe PMC";   PMID:22851558 "Europe PMC";   PMID:22913972 "Europe PMC";   PMID:23071237 "Europe PMC";   Patent:BE618638;   Patent:US2007122414;   Patent:US2008107661;   Patent:US3520926;   Patent:US3830840;   Reaxys:958270 "Reaxys";   Wikipedia:Procarbazine
 cyclic_relationship: is_conjugate_base_of CHEBI:71431

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procarbazine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aoc3 amine oxidase, copper containing 3 JBrowse link 10 89,251,370 89,259,313 RGD:6480464
G Ina internexin neuronal intermediate filament protein, alpha JBrowse link 1 266,782,835 266,794,389 RGD:6480464
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:6480464
G Prm1 protamine 1 JBrowse link 10 4,945,995 4,946,241 RGD:6480464
G Tk1 thymidine kinase 1 JBrowse link 10 106,817,556 106,828,888 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              procarbazine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  arenecarboxamide 6406
                                                    benzamides 6406
                                                      procarbazine 7
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